• 1
    Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. and Toda, M., Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 1995. 155: 11511164.
  • 2
    Itoh, M., Takahashi, T., Sakaguchi, N., Kuniyasu, Y., Shimizu, J., Otsuka, F. and Sakaguchi, S., Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 1999. 162: 53175326.
  • 3
    Xystrakis, E., Dejean, A. S., Bernard, I., Druet, P., Liblau, R., Gonzalez-Dunia, D. and Sauodi, A., Identification of a novel natural regulatory CD8 T cell subset and analysis of its mechanism of regulation. Blood 2004. 104: 32943301.
  • 4
    Baecher-Allan, C., Brown, J. A., Freeman, G. J. and Hafler, D. A., CD4+CD25high regulatory cells in human peripheral blood. J. Immunol. 2001. 167: 12451253.
  • 5
    Dejaco, C., Duftner, C., Grubeck-Loebenstein, B. and Schirmer, M., Imbalance of regulatory T cells in human autoimmune diseases. Immunology 2006. 117: 289300.
  • 6
    Raimondi, G., Shufesky, W. J., Tokita, D., Morelli, A. E. and Thomson, A. W., Regulated compartmentalization of programmed cell death-1 discriminates CD4+CD25+ resting regulatory T cells from activated T cells. J. Immunol. 2006. 176: 28082816.
  • 7
    Brunkow, M. E., Jeffery, E. W., Hjerrild, K. A., Paeper, B., Clark, L. B., Yasayko, S.-A., Wilkinson, J. E. et al., Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disease of the scurfy mouse. Nat. Genet. 2001. 27: 6873.
  • 8
    Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M. E., Ferguson, P. J., Whitesell, L., Kelly, T. E. et al., The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 2001. 27: 2021.
  • 9
    Chatila, T. A., Blaeser, F., Ho, N., Lederman, H. M., Voulgaropoulos, C., Helms, C. and Bowcock, A. M., JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. J. Clin. Invest. 2000. 106: R75R81.
  • 10
    Fontenot, J. D., Gavin, M. A. and Rudensky, A. Y., Foxp3 programs the development and function of CD4(+)CD25(+) regulatory T cells. Nat. Immunol. 2003. 4: 330336.
  • 11
    Hori, S., Nomura, T. and Sakaguchi, S., Control of regulatory T cell development by the transcription factor Foxp3. Science 2003. 299: 10571061.
  • 12
    Khattri, R., Cox, T., Yasayko, S.-A. and Ramsdell, F., An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat. Immunol. 2003. 4: 337342.
  • 13
    Fontenot, J. D., Rasmussen, J. P., Williams, L. M., Dooley, J. L., Farr, A. G. and Rudensky, A. Y., Regulatory T cell lineage specification by the forkhead transcription factor Foxp3. Immunity 2005. 22: 329341.
  • 14
    Roncador, G., Brown, P. J., Maestre, L., Hue, S., Martínez-Torrecuadrada, J. L., Ling, K.-L., Pratap, S. et al., Frontline: Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level. Eur. J. Immunol. 2005. 35: 16811691.
  • 15
    Fritzsching, B., Oberle, N., Pauly, E., Geffers, R., Buer, J., Pöschl, J., Krammer, P. H. et al., Naïve regulatory T cells: a novel subpopulation defined by resistance towards CD95L-mediated cell death. Blood 2006. In press.
  • 16
    Liu, W., Putnam, A. L., Xu-yu, Z., Szot, G. L., Lee, M. R., Zhu, S., Gottlieb, P. A. et al., CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J. Exp. Med. 2006. 203: 17011711.
  • 17
    Seddiki, N., Santer-Nanan, B., Martinson, J., Zaunders, J., Sasson, S., Landay, A., Solomon, M. et al., Expression of interleukin (IL)-2 and IL-7 receptors discriminates between regulatory and activated T cells. J. Exp. Med. 2006. 203: 16931700.
  • 18
    Allan, S. E., Passerini, L., Bacchetta, R., Crellin, N., Dai, M., Orban, P. C., Ziegler, S. F. et al., The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs. J. Clin. Invest. 2005. 115: 32763284.
  • 19
    Ziegler, S. F., FOXP3: of mice and men. Annu. Rev. Immunol. 2006. 24: 209226.
  • 20
    Walker, M. R., Kasprowicz, D. J., Gersuk, V. H., Benard, A., Van Landeghen, M., Buckner, J. H. and Ziegler, S. F., Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25 T cells. J. Clin. Invest. 2003. 112: 14371443.
  • 21
    Morgan, M. E., van Bilsen, J. H., Bakker, A. M., Heemskerk, B., Schilham, M. W., Hartgers, F. C., Elferink, B. G. et al., Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans. Hum. Immunol. 2005. 66: 1320.
  • 22
    Walker, M. R., Carson, B. D., Nepom, G. T., Ziegler, S. F. and Buckner, J. H., Proc. Natl. Acad. Sci. USA 2005. 102: 41034108.
  • 23
    Mantel, P. Y., Ouaked, N., Ruckert, B., Karagiannidis, C., Welz, R., Blaser, K. and Schmidt-Weber, C. B., Molecular mechanisms underlying FOXP3 induction in human T cells. J. Immunol. 2006. 176: 304310.
  • 24
    Gavin, M. A., Torgerson, T. T., Houston, E., deRoos, P., Ho, W. Y., Stray-Pedersen, A., Ocheltree, E. L. et al., Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc. Natl. Acad. Sci. USA 2006. 103: 66596664.
  • 25
    Becker, C., Fantini, M. C. and Neurath, M. F., TGF-beta as a T cell regulator in colitis and colon cancer. Cytokine Growth Factor Rev 2006. 17: 97106.
  • 26
    Kretschmer, K., Apostolou, I., Hawiger, D., Khazaie, K., Nussenzweig, M. C. and von Boehmer, H., Inducing and expanding regulatory T cell populations by foreign antigen. Nat. Immunol. 2005. 6: 12191227.
  • 27
    Klemke, C. D., Fritzsching, B., Franz, B., Kleinmann, E. V., Oberle, N., Poenitz, N., Sykora, J. et al., Paucity of FOXP3(+) cells in skin and peripheral blood distinguishes Sezary syndrome from other cutaneous T-cell lymphomas. Leukemia 2006. 20: 11231129.
  • 28
    Curiel, T. J., Coukos, G., Zou, L., Alvarez, X., Cheng, P., Mottram, P., Evdemon-Hogan, M. et al., Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat. Med. 2004. 10: 942949.
  • 29
    Roncador, G., Garcia, J. F., Garcia, J. F., Maestre, L., Lucas, E., Menarguez, J., Ohshima, K. et al., FOXP3, a selective marker for a subset of adult T-cell leukaemia/lymphoma. Leukemia 2005. 19: 22472253.
  • 30
    Walsh, P. T., Benoit, B. M., Wysocka, M., Dalton, N. M., Turka, L. A. and Rook, A. H., A role for regulatory T cells in cutaneous T-cell lymphoma; induction of a CD4+CD25+Foxp3+ T-cell phenotype associated with HTLV-1 infection. J. Invest. Dermatol. 2006. 126: 690692.
  • 31
    Berger, C. L., Tigelaar, R., Cohen, J., Mariwalla, K., Trink, J., Wang, N. and Edelson, R. L., Cutaneous T-cell lymphoma: malignant proliferation of T-regulatory cells. Blood 2005. 105: 16401647.
  • 32
    Zou, W., Regulatory T cells, tumour immunity and immunotherapy. Nat. Rev. Immunol. 2006. 6: 295307.
  • 33
    Valzasina, B., Piconese, S., Guiducci, C. and Colombo, M. P., Tumor-induced expansion of regulatory T cells by conversion of CD4+CD25 lymphocytes is thymus and proliferation independent. Cancer Res. 2006. 66: 44884495.
  • 34
    Ko, K., Yamazaki, S., Nakamura, K., Nishioka, T., Hirota, K., Yamaguchi, T, Shimizu, J. et al., Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells. J. Exp. Med. 2005. 202: 885891.
  • 35
    Alvaro, T., Lejeune, M., Salvado, M. T., Bosch, R., Garcia, J. F., Jaen, J., Banham, A. H. et al., Outcome in Hodgkin's lymphoma can be predicted from the presence of accompanying cytotoxic and regulatory T cells. Clin. Cancer Res. 2005. 11: 14671473.
  • 36
    Carreras, J., Lopez-Guillermo, A., Fox, B. C., Colomo, L., Martinez, A., Roncador, G., Monserrat, E. et al., High numbers of tumor infiltrating FOXP3-positive regulatory T cells are associated with improved overall survival in follicular lymphoma. Blood 2006. In press.
  • 37
    Prabhala, R. H., Neri, P., Bae, J. E., Tassone, P., Shammas, M. A., Allam, C. K., Daley, J. F. et al., Dysfunctional T regulatory cells in multiple myeloma. Blood 2006. 107: 301304.
  • 38
    Tiemessen, M. M., Mitchell, T. J., Hendry, L., Whittaker, S. J., Taams, L. S. and John, S., Lack of suppressive CD4+CD25+FOXP3+ T cells in advanced stages of primary cutaneous T-cell lymphoma. J. Invest. Dermatol. 2006. 126: 22172223.
  • 39
    Lim, H. W., Hillsamer, P., Banham, A. H. and Kim, C. H., Cutting Edge: Direct suppression of B cells by CD4+CD25+ regulatory T cells. J. Immunol. 2005. 175: 41804183.
  • 40
    Zhao, D. M., Thornton, A. M., DiPaolo, R. J. and Shevach, E. M., Activated CD4+CD25+ T cells selectively kill B lymphocytes. Blood 2006. 107: 39252932.
  • 41
    Zorn, E., CD4+CD25+ regulatory T cells in human hematopoietic cell transplantation. Semin. Cancer Biol. 2006. 16: 150159.
  • 42
    Masteller E. M., Tang, Q., Bluestone, J. A., Antigen-specific regulatory T cells – Ex vivo expansion and therapeutic potential. Semin. Immunol. 2006. 18:103110.