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    Potter, T. A., Rajan, T. V., Dick, R. F., 2nd and Bluestone, J. A., Substitution at residue 227 of H-2 class I molecules abrogates recognition by CD8-dependent, but not CD8-independent, cytotoxic T lymphocytes. Nature 1989. 337: 7375.
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    Xu, X. N., Purbhoo, M. A., Chen, N., Mongkolsapaya, J., Cox, J. H., Meier, U. C., Tafuro, S. et al., A novel approach to antigen-specific deletion of CTL with minimal cellular activation using alpha3 domain mutants of MHC class I/peptide complex. Immunity 2001. 14: 591602.
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    Schott, E. and Ploegh, H. L., Mouse MHC class I tetramers that are unable to bind to CD8 reveal the need for CD8 engagement in order to activate naive CD8 T cells. Eur. J. Immunol. 2002. 32: 34253434.
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    van der Merwe, P. A. and Davis, S. J., Molecular interactions mediating T cell antigen recognition. Annu. Rev. Immunol. 2003. 21: 659684.
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    Hutchinson, S. L., Wooldridge, L., Tafuro, S., Laugel, B., Glick, M., Boulter, J. M., Jakobsen, B. K. et al., The CD8 T cell coreceptor exhibits disproportionate biological activity at extremely low binding affinities. J. Biol. Chem. 2003. 278: 2428524293.
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    Irwin, M. J., Heath, W. R. and Sherman, L. A., Species-restricted interactions between CD8 and the alpha 3 domain of class I influence the magnitude of the xenogeneic response. J. Exp. Med. 1989. 170: 10911101.
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    Price, D. A., Brenchley, J. M., Ruff, L. E., Betts, M. R., Hill, B. J., Roederer, M., Koup, R. A. et al., Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses. J. Exp. Med. 2005. 202: 13491361.
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    Gostick, E., Cole, D. K., Hutchinson, S. L., Wooldridge, L., Tafuro, S., Laugel, B., Lissina, A. et al., Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor. Eur. J. Immunol. 2007. 37: 479486.
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    Devine, L., Sun, J., Barr, M. R. and Kavathas, P. B., Orientation of the Ig domains of CD8 alpha beta relative to MHC class I. J. Immunol. 1999. 162: 846851.
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    Sun, J. and Kavathas, P. B., Comparison of the roles of CD8 alpha alpha and CD8 alpha beta in interaction with MHC class I. J. Immunol. 1997. 159: 60776082.
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    Leishman, A. J., Naidenko, O. V., Attinger, A., Koning, F., Lena, C. J., Xiong, Y., Chang, H. C. et al., T cell responses modulated through interaction between CD8alphaalpha and the nonclassical MHC class I molecule, TL. Science 2001. 294: 19361939.
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    Zippelius, A., Pittet, M. J., Batard, P., Rufer, N., de Smedt, M., Guillaume, P., Ellefsen, K. et al., Thymic selection generates a large T cell pool recognizing a self-peptide in humans. J. Exp. Med. 2002. 195: 485494.
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    Salio, M., Shepherd, D., Dunbar, P. R., Palmowski, M., Murphy, K., Wu, L. and Cerundolo, V., Mature dendritic cells prime functionally superior melan-A-specific CD8+ lymphocytes as compared with nonprofessional APC. J. Immunol. 2001. 167: 11881197.
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    Hampl, J., Chien, Y. H. and Davis, M. M., CD4 augments the response of a T cell to agonist but not to antagonist ligands. Immunity 1997. 7: 379385.
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    Madrenas, J., Chau, L. A., Smith, J., Bluestone, J. A. and Germain, R. N., The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands. J. Exp. Med. 1997. 185: 219229.
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    Sewell, A. K., Harcourt, G. C., Goulder, P. J., Price, D. A. and Phillips, R. E., Antagonism of cytotoxic T lymphocyte-mediated lysis by natural HIV-1 altered peptide ligands requires simultaneous presentation of agonist and antagonist peptides. Eur. J. Immunol. 1997. 27: 23232329.
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    Kersh, G. J., Kersh, E. N., Fremont, D. H. and Allen, P. M., High- and low-potency ligands with similar affinities for the TCR: The importance of kinetics in TCR signaling. Immunity 1998. 9: 817826.
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    Lyons, D. S., Lieberman, S. A., Hampl, J., Boniface, J. J., Chien, Y., Berg, L. J. and Davis, M. M., A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. Immunity 1996. 5: 5361.
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    Zal, T., Zal, M. A. and Gascoigne, N. R., Inhibition of T cell receptor-coreceptor interactions by antagonist ligands visualized by live FRET imaging of the T-hybridoma immunological synapse. Immunity 2002. 16: 521534.
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    Klenerman, P., Cerundolo, V. and Dunbar, P. R., Tracking T cells with tetramers: New tales from new tools. Nat. Rev. Immunol. 2002. 2: 263272.
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    Boniface, J. J., Rabinowitz, J. D., Wulfing, C., Hampl, J., Reich, Z., Altman, J. D., Kantor, R. M. et al., Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands. Immunity 1998. 9: 459466.
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    Purbhoo, M. A., Irvine, D. J., Huppa, J. B. and Davis, M. M., T cell killing does not require the formation of a stable mature immunological synapse. Nat. Immunol. 2004. 5: 524530.
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    Dustin, M. L., Golan, D. E., Zhu, D. M., Miller, J. M., Meier, W., Davies, E. A. and van der Merwe, P. A., Low affinity interaction of human or rat T cell adhesion molecule CD2 with its ligand aligns adhering membranes to achieve high physiological affinity. J. Biol. Chem. 1997. 272: 3088930898.
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    Gakamsky, D. M., Luescher, I. F., Pramanik, A., Kopito, R. B., Lemonnier, F., Vogel, H., Rigler, R. and Pecht, I., CD8 kinetically promotes ligand binding to the T-cell antigen receptor. Biophys. J. 2005. 89: 21212133.
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    Price, D. A., Sewell, A. K., Dong, T., Tan, R., Goulder, P. J., Rowland-Jones, S. L. and Phillips, R. E., Antigen-specific release of beta-chemokines by anti-HIV-1 cytotoxic T lymphocytes. Curr. Biol. 1998. 8: 355358.
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    Purbhoo, M. A., Sewell, A. K., Klenerman, P., Goulder, P. J., Hilyard, K. L., Bell, J. I., Jakobsen, B. K. and Phillips, R. E., Copresentation of natural HIV-1 agonist and antagonist ligands fails to induce the T cell receptor signaling cascade. Proc. Natl. Acad. Sci. USA 1998. 95: 45274532.