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  • 1
    Seth, N., Kaufmann, D., Lahey, T., Rosenberg, E. S. and Wucherpfennig, K. W., Expansion and contraction of HIV-specific CD4 T cells with short bursts of viremia, but physical loss of the majority of these cells with sustained viral replication. J. Immunol. 2005. 175: 69486958.
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    Rosenberg, E. S., Billingsley, J. M., Caliendo, A. M., Boswell, S. L., Sax, P. E., Kalams, S. A. and Walker, B. D., Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia. Science 1997. 278: 14471450.
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    Rosenberg, E. S., Altfeld, M., Poon, S. H., Phillips, M. N., Wilkes, B. M., Eldridge, R. L., Robbins, G. K. et al., Immune control of HIV-1 after early treatment of acute infection. Nature 2000. 407: 523526.
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    Champagne, P., Ogg, G. S., King, A. S., Knabenhans, C., Ellefsen, K., Nobile, M., Appay, V. et al., Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature 2001. 410: 106111.
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    Lichterfeld, M., Kaufmann, D. E., Yu, X. G., Mui, S. K., Addo, M. M., Johnston, M. N., Cohen, D. et al., Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells. J. Exp. Med. 2004. 200: 701712.
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    Hammer, J., Sturniolo, T. and Sinigaglia, F., HLA class II peptide binding specificity and autoimmunity. Adv. Immunol. 1997. 66: 67100.
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    Castelli, F. A., Buhot, C., Sanson, A., Zarour, H., Pouvelle-Moratille, S., Nonn, C., Gahery-Segard, H. et al., HLA-DP4, the most frequent HLA II molecule, defines a new supertype of peptide-binding specificity. J. Immunol. 2002. 169: 69286934.
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    Pajot, A., Michel, M. L., Fazilleau, N., Pancre, V., Auriault, C., Ojcius, D. M., Lemonnier, F. A. and Lone, Y. C., A mouse model of human adaptive immune functions: HLA-A2.1-/HLA-DR1-transgenic H-2 class I-/class II-knockout mice. Eur. J. Immunol. 2004. 34: 30603069.
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    Moris, A., Pajot, A., Blanchet, F., Guivel-Benhassine, F., Salcedo, M. and Schwartz, O., Dendritic cells and HIV-specific CD4+ T cells: HIV antigen presentation, T cell activation, viral transfer. Blood 2006. 108: 16431651.
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    Boritz, E., Palmer, B. E., Livingston, B., Sette, A. and Wilson, C. C., Diverse repertoire of HIV-1 p24-specific, IFN--gamma-producing CD4+ T cell clones following immune reconstitution on highly active antiretroviral therapy. J. Immunol. 2003. 170: 11061116.
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    Wilson, C. C., Palmer, B., Southwood, S., Sidney, J., Higashimoto, Y., Appella, E., Chesnut, R. et al., Identification and antigenicity of broadly cross-reactive and conserved human immunodeficiency virus type 1-derived helper T-lymphocyte epitopes. J. Virol. 2001. 75: 41954207.
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    Iyasere, C., Tilton, J. C., Johnson, A. J., Younes, S., Yassine-Diab, B., Sekaly, R. P., Kwok, W. W. et al., Diminished proliferation of human immunodeficiency virus-specific CD4+ T cells is associated with diminished interleukin-2 (IL-2) production and is recovered by exogenous IL-2. J. Virol. 2003. 77: 1090010909.
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    Kaufmann, D. E., Bailey, P. M., Sidney, J., Wagner, B., Norris, P. J., Johnston, M. N., Cosimi, L. A. et al., Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides. J. Virol. 2004. 78: 44634477.
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    Venturini, S., Mosier, D. E., Burton, D. R. and Poignard, P., Characterization of human immunodeficiency virus type 1 (HIV-1) Gag- and Gag peptide-specific CD4(+) T-cell clones from an HIV-1-seronegative donor following in vitro immunization. J. Virol. 2002. 76: 69876999.
  • 15
    Pantaleo, G., Graziosi, C. and Fauci, A. S., Virologic and immunologic events in primary HIV infection. Springer Semin. Immunopathol. 1997. 18: 257266.
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    Firat, H., Tourdot, S., Ureta-Vidal, A., Scardino, A., Suhrbier, A., Buseyne, F., Riviere, Y. et al., Design of a polyepitope construct for the induction of HLA-A0201-restricted HIV 1-specific CTL responses using HLA-A*0201 transgenic, H-2 class I KO mice. Eur. J. Immunol. 2001. 31: 30643074.
  • 17
    Stern, L. J., Brown, J. H., Jardetzky, T. S., Gorga, J. C., Urban, R. G., Strominger, J. L. and Wiley, D. C., Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature 1994. 368: 215221.
  • 18
    Sponaas, A., Carstens, C. and Koch, N., C-terminal extension of the MHC class II-associated invariant chain by an antigenic sequence triggers activation of naive T cells. Gene Ther. 1999. 6: 18261834.
  • 19
    Rodriguez, F., Harkins, S., Redwine, J. M., de Pereda, J. M. and Whitton, J. L., CD4(+) T cells induced by a DNA vaccine: immunological consequences of epitope-specific lysosomal targeting. J. Virol. 2001. 75: 1042110430.
  • 20
    Pajot, A., Pancre, V. V., Fazilleau, N., Michel, M. L., Angyalosi, G., Ojcius, D. M., Auriault, C. et al., Comparison of HLA-DR1-restricted T cell response induced in HLA-DR1 transgenic mice deficient for murine MHC class II and HLA-DR1 transgenic mice expressing endogenous murine MHC class II molecules. Int. Immunol. 2004. 16: 12751282.
  • 21
    Loirat, D., Lemonnier, F. A. and Michel, M. L., Multiepitopic HLA-A*0201-restricted immune response against hepatitis B surface antigen after DNA-based immunization. J. Immunol. 2000. 165: 47484755.
  • 22
    Freisewinkel, I. M., Schenck, K. and Koch, N., The segment of invariant chain that is critical for association with major histocompatibility complex class II molecules contains the sequence of a peptide eluted from class II polypeptides. Proc. Natl. Acad. Sci. USA 1993. 90: 97039706.
  • 23
    Candotti, D., Costagliola, D., Joberty, C., Bonduelle, O., Rouzioux, C., Autran, B. and Agut, H., Status of long-term asymptomatic HIV-1 infection correlates with viral load but not with virus replication properties and cell tropism. French ALT Study Group. J. Med. Virol. 1999. 58: 256263.
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    Forsthuber, T., Yip, H. C. and Lehmann, P. V., Induction of Th1 and Th2 immunity in neonatal mice. Science 1996. 271: 17281730.
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    Samri, A., Durier, C., Urrutia, A., Sanchez, I., Gahery-Segard, H., Imbart, S., Sinet, M. et al., Evaluation of the interlaboratory concordance in quantification of human immunodeficiency virus-specific T cells with a gamma interferon enzyme-linked immunospot assay. Clin. Vaccine Immunol. 2006. 13: 684697.
  • 26
    Brossart, P., Grunebach, F., Stuhler, G., Reichardt, V. L., Mohle, R., Kanz, L. and Brugger, W., Generation of functional human dendritic cells from adherent peripheral blood monocytes by CD40 ligation in the absence of granulocyte-macrophage colony-stimulating factor. Blood 1998. 92: 42384247.