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  • 1
    Fantini, M. C., Becker, C., Monteleone, G., Pallone, F., Galle, P. R. and Neurath, M. F., Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25 T cells through Foxp3 induction and down-regulation of Smad7. J. Immunol. 2004. 172: 51495153.
  • 2
    Kretschmer, K., Apostolou, I., Hawiger, D., Khazaie, K., Nussenzweig, M. C. and von Boehmer, H., Inducing and expanding regulatory T cell populations by foreign antigen. Nat. Immunol. 2005. 6: 12191227.
  • 3
    Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M. and Stockinger, B., TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006. 24: 179189.
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    Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D. et al., Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 2006. 441: 231234.
  • 5
    Chen, W., Jin, W., Hardegen, N., Lei, K. J., Li, L., Marinos, N., McGrady, G. and Wahl, S. M., Conversion of peripheral CD4+CD25 naïve T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 2003. 198: 18751886.
  • 6
    Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L. and Kuchroo, V. K., Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006. 441: 235238.
  • 7
    Fantini, M. C., Becker, C., Tubbe, I., Nikolaev, A., Lehr, H. A., Galle, P. and Neurath, M. F., Transforming growth factor beta induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis. Gut 2006. 55: 671680.
  • 8
    Villarino, A. V., Huang, E. and Hunter, C. A., Understanding the pro- and anti-inflammatory properties of IL-27. J. Immunol. 2004. 173: 715720.
  • 9
    Huehn, J., Siegmund, K., Lehmann, J. C., Siewert, C., Haubold, U., Feuerer, M., Debes, G. F. et al., Developmental stage, phenotype, and migration distinguish naïve- and effector/memory-like CD4+ regulatory T cells. J. Exp. Med. 2004. 199: 303313.
  • 10
    Pflanz, S., Timans, J. C., Cheung, J., Rosales, R., Kanzler, H., Gilbert, J., Hibbert, L. et al., IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naïve CD4(+) T cells. Immunity 2002. 16: 779790.
  • 11
    Chen, Q., Ghilardi, N., Wang, H., Baker, T., Xie, M. H., Gurney, A., Grewal, I. S. and de Sauvage, F. J., Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature 2000. 407: 916920.
  • 12
    Wirtz, S., Becker, C., Fantini, M. C., Nieuwenhuis, E. E., Tubbe, I., Galle, P. R., Schild, H. J. et al., EBV-induced gene 3 transcription is induced by TLR signaling in primary dendritic cells via NF-kappa B activation. J. Immunol. 2005. 174: 28142824.
  • 13
    Takeda, A., Hamano, S., Yamanaka, A., Hanada, T., Ishibashi, T., Mak, T. W., Yoshimura, A. and Yoshida, H., Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. J. Immunol. 2003. 170: 48864890.
  • 14
    Lucas, S., Ghilardi, N., Li, J. and de Sauvage, F. J., IL-27 regulates IL-12 responsiveness of naïve CD4+ T cells through Stat1-dependent and -independent mechanisms. Proc. Natl. Acad. Sci. USA 2003. 100: 1504715052.
  • 15
    Batten, M., Li, J., Yi, S., Kljavin, N. M., Danilenko, D. M., Lucas, S., Lee, J. et al., Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat. Immunol. 2006. 7: 929936.
  • 16
    Stumhofer, J. S., Laurence, A., Wilson, E. H., Huang, E., Tato, C. M., Johnson, L. M., Villarino, A. V. et al., Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat. Immunol. 2006. 7: 937945.
  • 17
    Wirtz, S., Tubbe, I., Galle, P. R., Schild, H. J., Birkenbach, M., Blumberg, R. S. and Neurath, M. F., Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27. J. Exp. Med. 2006. 203: 18751881.
  • 18
    Holscher, C., Holscher, A., Ruckerl, D., Yoshimoto, T., Yoshida, H., Mak, T., Saris, C. and Ehlers, S., The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis. J. Immunol. 2005. 174: 35343544.
  • 19
    Goldberg, R., Zohar, Y., Wildbaum, G., Geron, Y., Maor, G. and Karin, N., Suppression of ongoing experimental autoimmune encephalomyelitis by neutralizing the function of the p28 subunit of IL-27. J. Immunol. 2004. 173: 64656471.
  • 20
    Nieuwenhuis, E. E., Neurath, M. F., Corazza, N., Iijima, H., Trgovcich, J., Wirtz, S., Glickman, J. et al., Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice. Proc. Natl. Acad. Sci. USA 2002. 99: 1695116956.
  • 21
    Kirberg, J., Baron, A., Jakob, S., Rolink, A., Karjalainen, K. and von Boehmer, H., Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor. J. Exp. Med. 1994. 180: 2534.
  • 22
    D'Cruz, L. M. and Klein, L., Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling. Nat. Immunol. 2005. 6: 11521159.
  • 23
    Fontenot, J. D., Rasmussen, J. P., Gavin, M. A. and Rudensky, A. Y., A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat. Immunol. 2005. 6: 11421151.
  • 24
    Lohr, J., Knoechel, B. and Abbas, A. K., Regulatory T cells in the periphery. Immunol. Rev. 2006. 212: 149162.
  • 25
    Zheng, S. G., Wang, J., Wang, P., Gray, J. D. and Horwitz, D. A., IL-2 is essential for TGF-beta to convert naïve CD4+CD25 cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J. Immunol. 2007. 178: 20182027.
  • 26
    Villarino, A. V., Stumhofer, J. S., Saris, C. J., Kastelein, R. A., de Sauvage, F. J. and Hunter, C. A., IL-27 limits IL-2 production during Th1 differentiation. J. Immunol. 2006. 176: 237247.
  • 27
    Owaki, T., Asakawa, M., Kamiya, S., Takeda, K., Fukai, F., Mizuguchi, J. and Yoshimoto, T., IL-27 suppresses CD28-mediated [correction of medicated] IL-2 production through suppressor of cytokine signaling 3. J. Immunol. 2006. 176: 27732780.
  • 28
    MacDonald, T. T. and Monteleone, G., Immunity, inflammation, and allergy in the gut. Science 2005. 307: 19201925.
  • 29
    Nakamura, K., Kitani, A., Fuss, I., Pedersen, A., Harada, N., Nawata, H. and Strober, W., TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice. J. Immunol. 2004. 172: 834842.
  • 30
    Takeda, K., Kaisho, T., Yoshida, N., Takeda, J., Kishimoto, T. and Akira, S., Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. J. Immunol. 1998. 161: 46524660.
  • 31
    Yang, X. O., Panopoulos, A. D., Nurieva, R., Chang, S. H., Wang, D., Watowich, S. S. and Dong, C., STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J. Biol. Chem. 2007
  • 32
    Nishibori, T., Tanabe, Y., Su, L. and David, M., Impaired development of CD4+ CD25+ regulatory T cells in the absence of STAT1: increased susceptibility to autoimmune disease. J. Exp. Med. 2004. 199: 2534.