• 1
    Ziegler, S. F., FOXP3: of mice and men. Annu. Rev. Immunol. 2006. 24: 209226.
  • 2
    Fontenot, J. D. and Rudensky, A. Y., A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat. Immunol. 2005. 6: 331337.
  • 3
    Sakaguchi, S., Regulatory T cells: key controllers of immunologic self-tolerance. Cell 2000. 101: 455458.
  • 4
    Shevach, E. M., Regulatory T cells in autoimmunity. Annu. Rev. Immunol. 2000. 18: 423449.
  • 5
    Hsieh, C. S., Zheng, Y., Liang, Y., Fontenot, J. D. and Rudensky, A. Y., An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat. Immunol. 2006. 7: 401410.
  • 6
    Fontenot, J. D., Gavin, M. A. and Rudensky, A. Y., FoxP3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 2003. 4: 330336.
  • 7
    Hori, S., Nomura, T. and Sakaguchi, S., Control of regulatory T cell development by the transcription factor FoxP3. Science 2003. 299: 10571061.
  • 8
    Fontenot, J. D., Rasmussen, J. P., Williams, L. M., Dooley, J. L., Farr, A. G. and Rudensky, A. Y., Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity. 2005. 22: 329341.
  • 9
    Baecher-Allan, C., Brown, J. A., Freeman, G. J. and Hafler, D. A., CD4+CD25high regulatory cells in human peripheral blood. J. Immunol. 2001. 167: 12451253.
  • 10
    Levings, M. K., Sangregorio, R. and Roncarolo, M. G., Human CD25+CD4+ T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J. Exp. Med. 2001. 193: 12951302.
  • 11
    Walker, M. R., Kasprowicz, D. J., Gersuk, V. H., Benard, A., Van Landeghen, M., Buckner, J. H. and Ziegler, S. F., Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells. J. Clin. Invest. 2003. 112: 14371443.
  • 12
    Morgan, M. E., van Bilsen, J. H., Bakker, A. M., Heemskerk, B., Schilham, M. W., Hartgers, F. C., Elferink, B. G. et al., Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans. Hum. Immunol. 2005. 66: 1320.
  • 13
    Allan, S. E., Passerini, L., Bacchetta, R., Crellin, N., Da, M., Orban, P. C., Ziegler, S. F. and Roncarolo, M. G., The role of FOXP3, and an isoform lacking exon 2, in the generation of human CD4+ T regulatory cells. J. Clin. Invest. 2005. 115: 32763284.
  • 14
    Gavin, M. A., Torgerson, T. R., Houston, E., deRoos, P. , Ho, W. Y. , Stray-Pedersen, A. , Ocheltree, E. L. et al., Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc. Natl. Acad. Sci. USA 2006. 103: 66596664.
  • 15
    Wang, J., Ioan-Facsinay, A., van der Voort, E. I. H., Huizinga, T. W. J. and Toes, R. E. M., Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells Eur. J. Immunol 37: DOI 10.1002/eji200636435
  • 16
    Mantel, P-Y., Ouaked, N., Rückert, B., Karagiannidis, C., Welz, R., Blaser, K. and Schmidt-Weber, C. B., Molecular mechanisms underlying FOXP3 induction in human T cells. J. Immunol. 2006. 176: 35933602.
  • 17
    Schubert, L. A., Jeffery, E. W., Zhang, Y., Ramsdell, F. and Ziegler, S. F., Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation. J. Biol. Chem. 2001. 276: 3767237679.
  • 18
    Wu, Y., Borde, M., Heissmeyer, V., Feuerer, M., Lapan, A. D., Stroud, J. C., Bates, D. L. et al., FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 2006. 126: 375387.
  • 19
    Tsang, J. Y-S., Camara, N. O. S., Eren, E., Schneider, H., Rudd, C., Lombardi, G. and Lechler, R., Altered proximal T cell receptor (TCR) signaling in human CD4+CD25+ regulatory T cells. J. Leuk. Biol. 2006. 80: 145151.
  • 20
    Hickman, S. P., Yang, J., Thomas, R. M., Wells, A. D. and Turka, L. A., Defective activation of protein kinase C and Ras-Erk pathways limits IL-2 production and proliferation by CD4+CD25+ regulatory T cells. J. Immunol. 2006. 177: 21862194.