• 1
    Strengell, M., Sareneva, T., Foster, D., Julkunen, I. and Matikainen, S., IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response. J. Immunol. 2002. 169: 36003605.
  • 2
    Sullivan, B. M., Juedes, A., Szabo, S. J., von Herrath, M. and Glimcher, L. H., Antigen-driven effector CD8 T cell function regulated by T-bet. Proc. Natl. Acad. Sci. USA 2003. 100: 1581815823.
  • 3
    Szabo, S. J., Sullivan, B. M., Stemmann, C., Satoskar, A. R., Sleckman, B. P. and Glimcher, L. H., Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 2002. 295: 338342.
  • 4
    Townsend, M. J., Weinmann, A. S., Matsuda, J. L., Salomon, R., Farnham, P. J., Biron, C. A., Gapin, L. and Glimcher, L. H., T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. Immunity 2004. 20: 477494.
  • 5
    Mullen, A. C., High, F. A., Hutchins, A. S., Lee, H. W., Villarino, A. V., Livingston, D. M., Kung, A. L. et al., Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science 2001. 292: 19071910.
  • 6
    Mullen, A. C., Hutchins, A. S., Villarino, A. V., Lee, H. W., High, F. A., Cereb, N., Yang, S. Y. et al., Cell cycle controlling the silencing and functioning of mammalian activators. Curr. Biol. 2001. 11: 16951699.
  • 7
    Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G. and Glimcher, L. H., A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000. 100: 655669.
  • 8
    Harris, D. P., Goodrich, S., Gerth, A. J., Peng, S. L. and Lund, F. E., Regulation of IFN-gamma production by B effector 1 cells: essential roles for T-bet and the IFN-gamma receptor. J. Immunol. 2005. 174: 67816790.
  • 9
    Lugo-Villarino, G., Maldonado-Lopez, R., Possemato, R., Penaranda, C. and Glimcher, L. H., T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells. Proc. Natl. Acad. Sci. USA 2003. 100: 77497754.
  • 10
    Bettelli, E., Sullivan, B., Szabo, S. J., Sobel, R. A., Glimcher, L. H. and Kuchroo, V. K., Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J. Exp. Med. 2004. 200: 7987.
  • 11
    Finotto, S., Neurath, M. F., Glickman, J. N., Qin, S., Lehr, H. A., Green, F. H., Ackerman, K. et al., Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science 2002. 295: 336338.
  • 12
    Glimcher, L. H., Townsend, M. J., Sullivan, B. M. and Lord, G. M., Recent developments in the transcriptional regulation of cytolytic effector cells. Nat. Rev. Immunol. 2004. 4: 900911.
  • 13
    Juedes, A. E., Rodrigo, E., Togher, L., Glimcher, L. H. and von Herrath, M. G., T-bet controls autoaggressive CD8 lymphocyte responses in type 1 diabetes. J. Exp. Med. 2004. 199: 11531162.
  • 14
    Neurath, M. F., Weigmann, B., Finotto, S., Glickman, J., Nieuwenhuis, E., Iijima, H., Mizoguchi, A. et al., The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease. J. Exp. Med. 2002. 195: 11291143.
  • 15
    Gorelik, L., Constant, S. and Flavell, R. A., Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation. J. Exp. Med. 2002. 195: 14991505.
  • 16
    Afkarian, M., Sedy, J. R., Yang, J., Jacobson, N. G., Cereb, N., Yang, S. Y., Murphy, T. L. and Murphy, K. M., T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells. Nat. Immunol. 2002. 3: 549557.
  • 17
    Lighvani, A. A., Frucht, D. M., Jankovic, D., Yamane, H., Aliberti, J., Hissong, B. D., Nguyen, B. V. et al., T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells. Proc. Natl. Acad. Sci. USA 2001. 98: 1513715142.
  • 18
    Gavrilescu, L. C., Butcher, B. A., Del Rio, L., Taylor, G. A. and Denkers, E. Y., STAT1 is essential for antimicrobial effector function but dispensable for gamma interferon production during Toxoplasma gondii infection. Infect. Immun. 2004. 72: 12571264.
  • 19
    Maekawa, Y., Tsukumo, S., Chiba, S., Hirai, H., Hayashi, Y., Okada, H., Kishihara, K. and Yasutomo, K., Delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T cells. Immunity 2003. 19: 549559.
  • 20
    Lin, J. T., Martin, S. L., Xia, L. and Gorham, J. D., TGF-beta 1 uses distinct mechanisms to inhibit IFN-gamma expression in CD4+ T cells at priming and at recall: differential involvement of Stat4 and T-bet. J. Immunol. 2005. 174: 59505958.
  • 21
    Yu, J., Wei, M., Becknell, B., Trotta, R., Liu, S., Boyd, Z., Jaung, M. S. et al., Pro- and antiinflammatory cytokine signaling: reciprocal antagonism regulates interferon-gamma production by human natural killer cells. Immunity 2006. 24: 575590.
  • 22
    Minter, L. M., Turley, D. M., Das, P., Shin, H. M., Joshi, I., Lawlor, R. G., Cho, O. H. et al., Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21. Nat. Immunol. 2005. 6: 680688.
  • 23
    Kadonaga, J. T., Carner, K. R., Masiarz, F. R. and Tjian, R., Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain. Cell 1987. 51: 10791090.
  • 24
    Li, L., He, S., Sun, J. M. and Davie, J. R., Gene regulation by Sp1 and Sp3. Biochem. Cell. Biol. 2004. 82: 460471.
  • 25
    Blume, S. W., Snyder, R. C., Ray, R., Thomas, S., Koller, C. A. and Miller, D. M., Mithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo. J. Clin. Invest. 1991. 88: 16131621.
  • 26
    Koga, T., Suico, M. A., Nakamura, H., Taura, M., Lu, Z., Shuto, T., Okiyoneda, T. and Kai, H., Sp1-dependent regulation of myeloid Elf-1 like factor in human epithelial cells. FEBS Lett. 2005. 579: 28112816.
  • 27
    Koutsodontis, G. and Kardassis, D., Inhibition of p53-mediated transcriptional responses by mithramycin A. Oncogene 2004. 23: 91909200.
  • 28
    Esteve, P. O., Chin, H. G. and Pradhan, S., Molecular mechanisms of transactivation and doxorubicin-mediated repression of survivin gene in cancer cells. J. Biol. Chem. 2007. 282: 26152625.
  • 29
    Safe, S. and Abdelrahim, M., Sp transcription factor family and its role in cancer. Eur. J. Cancer 2005. 41: 24382448.
  • 30
    Chen, H. M., Pahl, H. L., Scheibe, R. J., Zhang, D. E. and Tenen, D. G., The Sp1 transcription factor binds the CD11b promoter specifically in myeloid cells invivo and is essential for myeloid-specific promoter activity. J. Biol. Chem. 1993. 268: 82308239.
  • 31
    Lopez-Soto, A., Quinones-Lombrana, A., Lopez-Arbesu, R., Lopez-Larrea, C. and Gonzalez, S., Transcriptional regulation of ULBP1, a human ligand of the NKG2D receptor. J. Biol. Chem. 2006. 281: 3041930430.
  • 32
    Ajlouni, K. and Theil, G. B., Mithramycin effects on calcium, phosphorus and parathyroid hormone in osseous Paget's disease. Am. J. Med. Sci. 1975. 269: 1318.
  • 33
    Feng, X. H., Lin, X. and Derynck, R., Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta. EMBO J. 2000. 19: 51785193.
  • 34
    Poncelet, A. C. and Schnaper, H. W., Sp1 and Smad proteins cooperate to mediate transforming growth factor-beta 1-induced alpha 2(I) collagen expression in human glomerular mesangial cells. J. Biol. Chem. 2001. 276: 69836992.
  • 35
    Datta, P. K., Blake, M. C. and Moses, H. L., Regulation of plasminogen activator inhibitor-1 expression by transforming growth factor-beta -induced physical and functional interactions between smads and Sp1. J. Biol. Chem. 2000. 275: 4001440019.
  • 36
    Zhang, X., Yang, J., Li, Y. and Liu, Y., Both Sp1 and Smad participate in mediating TGF-β1-induced HGF receptor expression in renal epithelial cells. Am. J. Physiol. Renal Physiol. 2005. 288: F16-F26.
  • 37
    Waldmann, T., Tagaya, Y. and Bamford, R., Interleukin-2, interleukin-15, and their receptors. Int. Rev. Immunol. 1998. 16: 205226.
  • 38
    Lacroix, I., Lipcey, C., Imbert, J. and Kahn-Perles, B., Sp1 transcriptional activity is up-regulated by phosphatase 2A in dividing T lymphocytes. J. Biol. Chem. 2002. 277: 95989605.
  • 39
    Too, C. K., Induction of Sp1 activity by prolactin and interleukin-2 in Nb2 T-cells: differential association of Sp1-DNA complexes with Stats. Mol. Cell. Endocrinol. 1997. 129: 716.
  • 40
    Schroder, K., Hertzog, P. J., Ravasi, T. and Hume, D. A., Interferon-gamma: an overview of signals, mechanisms and functions. J. Leukoc. Biol. 2004. 75: 163189.
  • 41
    Dunn, G. P., Ikeda, H., Bruce, A. T., Koebel, C., Uppaluri, R., Bui, J., Chan, R. et al., Interferon-gamma and cancer immunoediting. Immunol. Res. 2005. 32: 231245.
  • 42
    Sutherland, C. L., Rabinovich, B., Chalupny, N. J., Brawand, P., Miller, R. and Cosman, D., ULBPs, human ligands of the NKG2D receptor, stimulate tumor immunity with enhancement by IL-15. Blood 2006. 108: 13131319.
  • 43
    Trotta, R., Parihar, R., Yu, J., Becknell, B., Allard, J., 2nd, Wen, J., Ding, W. et al., Differential expression of SHIP1 in CD56bright and CD56dim NK cells provides a molecular basis for distinct functional responses to monokine costimulation. Blood 2005. 105: 30113018.
  • 44
    Hong, J. W., Allen, C. E. and Wu, L. C., Inhibition of NF-kappaB by ZAS3, a zinc-finger protein that also binds to the kappaB motif. Proc. Natl. Acad. Sci. USA 2003. 100: 1230112306.
  • 45
    Becknell, B., Trotta, R., Yu, J., Ding, W., Mao, H. C., Hughes, T., Marburger, T. and Caligiuri, M. A., Efficient infection of human natural killer cells with an EBV/retroviral hybrid vector. J. Immunol. Methods 2005. 296: 115123.
  • 46
    Wu, L. C., Mak, C. H., Dear, N., Boehm, T., Foroni, L. and Rabbitts, T. H., Molecular cloning of a zinc finger protein which binds to the heptamer of the signal sequence for V(D)J recombination. Nucleic Acids Res. 1993. 21: 50675073.
  • 47
    Fehniger, T. A., Shah, M. H., Turner, M. J., VanDeusen, J. B., Whitman, S. P., Cooper, M. A., Suzuki, K. et al., Differential cytokine and chemokine gene expression by human NK cells following activation with IL-18 or IL-15 in combination with IL-12: implications for the innate immune response. J. Immunol. 1999. 162: 45114520.