• 1
    Sadelain, M. W., Qin, H. Y., Lauzon, J. and Singh, B., Prevention of type I diabetes in NOD mice by adjuvant immunotherapy. Diabetes 1990 39: 583.
  • 2
    McInerney, M. F., Pek, S. B. and Thomas, D. W., Prevention of insulitis and diabetes onset by treatment with complete Freund's adjuvant in NOD mice. Diabetes 1991 40: 715.
  • 3
    Lakey, J. R., Wang, T., Warnock, G. L., Singh, B. and Rajotte, R. V., Prevention of recurrence of insulin-dependent diabetes mellitus in islet cell-transplanted diabetic NOD mice using adjuvant therapy. Transplant. Proc. 1992 24: 2848.
  • 4
    Qin, H. Y., Sadelain, M. W., Hitchon, C., Lauzon, J. and Singh, B., Complete Freund's adjuvant-induced T cells prevent the development and adoptive transfer of diabetes in nonobese diabetic mice. J. Immunol. 1993 150: 2072.
  • 5
    Lee, I. F., Qin, H., Trudeau, J., Dutz, J. and Tan, R., Regulation of autoimmune diabetes by complete Freund's adjuvant is mediated by NK cells. J. Immunol. 2004 172: 937.
  • 6
    Montoya, C. J., Velilla, P. A., Chougent, C., Landay, A. L. and Rugeles, M. T., Increased IFN-γ production by NK and CD3+/CD56+ cells in sexually HIV-1-exposed but uninfected individuals. Clin. Immunol. 2006 120:138.
  • 7
    Biron, C. A., Nguyen, K. B., Pien, G. C., Cousens, L. P. and Salazar-Mather, T. P., Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu. Rev. Immunol. 1999 17: 189.
  • 8
    Takahashi, K., Aranami, T. and Endoh, M., The regulation role of natural killer cells in multiple sclerosis. Brain 2004 127: 1917.
  • 9
    Toyabe, S., Kaneko, U. and Uchiyama, M., Decreased DAP12 expression in natural killer lymphocytes from patients with systemic lupus erythematosus is associated with increased transcript mutation. J. Autoimmun. 2004 23: 371.
  • 10
    Green, M. R., Kennell, A. S., Larche, M. J., Seifert, M. H., Isenberg, D. A. and Salaman, M. R., Natural killer cell activity in families of patients with systemic lupus erythematosus: demonstration of a killing defect in patients. Clin. Exp. Immunol. 2005 141: 165.
  • 11
    Carnaud, C., Gombert, J., Donnars, O., Garchon, H. and Herbelin, A., Protection against diabetes and improved NK/NKT cell performance in NOD.NK1.1 mice congenic at the NK complex. J. Immunol. 2001 166: 2404.
  • 12
    Poulton, L. D., Smyth, M. J., Hawke, C. G., Silveira, P., Shepherd, D., Naidenko, O. V., Godfrey, D. I. and Baxter, A. G., Cytometric and functional analyses of NK and NKT cell deficiencies in NOD mice. Int. Immunol. 2001 13: 887.
  • 13
    Johnsson, S. E., Hall, H., Bjorklund, J. and Hoglund, P., Broadly impaired NK cell function in non-obese diabetic mice is partially restored by NK cell activation in vivo and by IL-12/IL-18 in vitro. Int. Immunol. 2004 16: 1.
  • 14
    Serreze, D. V., Chapman, H. D., Post, C. M., Johnson, E. A., Suarez-Pinzon, W. L. and Rabinovitch, A., Th1 to Th2 cytokine shifts in nonobese diabetic mice: sometimes an outcome, rather than the cause, of diabetes resistance elicited by immunostimulation. J. Immunol. 2001 166: 1352.
  • 15
    Ogasawara, K., Hamerman, J. A., Hsin, H., Chikuma, S., Bour-Jordan, H., Chen, T., Pertel, T. et al., Impairment of NK cell function by NKG2D modulation in NOD mice. Immunity 2003 18: 41.
  • 16
    Trembleau, S., Penna, G., Gregori, S., Giarratana, N. and Adorini, L., IL-12 administration accelerates autoimmune diabetes in both wild-type and IFN-gamma-deficient nonobese diabetic mice, revealing pathogenic and protective effects of IL-12-induced IFN-gamma. J. Immunol. 2003 170: 5491.
  • 17
    Dalton, D. K., Haynes, L., Chu, C. Q., Swain, S. L. and Wittmer, S., Interferon gamma eliminates responding CD4 T cells during mycobacterial infection by inducing apoptosis of activated CD4 T cells. J. Exp. Med. 2000 192: 117.
  • 18
    O'Connor, R. A., Wittmer, S. and Dalton, D. K., Infection-induced apoptosis deletes bystander CD4+ T cells: a mechanism for suppression of autoimmunity during BCG infection. J. Autoimmun. 2005 24: 93.
  • 19
    Sobel, D. O., Han, J., Williams, J., Yoon, J. W., Jun, H. S. and Ahvazi, B., Gamma interferon paradoxically inhibits the development of diabetes in the NOD mouse. J. Autoimmun. 2002 19: 129.
  • 20
    Qin, H. Y., Chaturvedi, P. and Singh, B., In vivo apoptosis of diabetogenic T cells in NOD mice by IFN-gamma/TNF-alpha. Int. Immunol. 2004 16: 1723.
  • 21
    Cnop., M., Welsh, N., Jonas, J. C., Jorns, A., Lenzen, S. and Eizirik, D. L., Mechnisms of pancreatic beta-cell death in type 1 and type2 diabetes: many differences, few similarities. Diabetes 2005 54 suppl. 2: S97.
  • 22
    Rasschaert, J., Ladriere, L., Urbain, M., Dogusan, Z., Katabua, B., Sato, S., Akira, S. et al., Toll-like receptors and STAT-1 contribute to double-stranded RNA + interferon-gamma-induced apoptosis in primary pancreatic beta-cells. J. Biol. Chem. 2005 280: 33984.
  • 23
    Suk K., Kim, S., Kim, Y. H., Kim, K. A., Chang, I., Yagita, H., Shong, M. and Lee, M. S., IFN-gamma/TNF-alpha synergism as a final effector in autoimmune diabetes: a key role for STAT1/IFN regulatory factor-1 pathway in pancreatic beta-cell death. J. Immunol. 2001 166: 4481.
  • 24
    Campbell, I. L., Iscaro, A. and Harrison, L. C., Interferon-gamma and tumor necrosis factor-alpha. Cytotoxicity to murine islets of Langerhans. J. Immunol. 1988 141: 2325.
  • 25
    Zhou, R., Wei, H. and Zhigang, T., NK3-like NK cells are involved in protective effects of polyinosinic-polycytidylic acid on type 1 diabetes in nonobese diabetic mice. J. mmunol. 2007 178: 2141.
  • 26
    Peritt, D., Robertson, S., Gri, G., Showe, L., Aste-Amezaga, M. and Trinchieri, G., Differentiation of human NK cells into NK1 and NK2 subsets. J. Immunol. 1998 161: 821.
  • 27
    Hoshino, T., Winkler-Pichett, R. T., Mason, A. T., Ortaldo, J. R. and Young, H. A., IL-13 production by NK cells: IL-13-producing NK and T cells are present in vivo in the absence of IFN-γ. J. Immunol. 1999 162: 1.
  • 28
    Warren, H. S., Kinnear, B. F., Phillips, J. H. and Lanier, L. L., Production of IL-5 by human NK cells and regulation of IL-5 secretion by IL-4, IL-10 and IL-12. J. Immunol. 1995 154: 144.
  • 29
    Loza, M. J. and Perussia, B., Final steps of natural killer cell maturation: a model for type 1-type 2 differentiation? Nat. Immunol. 2001 2: 917.
  • 30
    Coudert, J. D., Zimmer, J., Tomasello, E., Cebecauer, M., Colonna, M., Vivier, E. and Held, W., Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand-expressing tumor cells. Blood 2005 106: 1711.
  • 31
    Roda-Navarro, P., Vales-Gomez, M., Chisholm, S. E. and Reyburn, H. T., Transfer of NKG2D and MICB at the cytotoxic NK cell immune synapse correlates with a reduction in NK cell cytotoxic function. Proc. Natl. Acad. Sci. USA 2006 103: 11258.
  • 32
    Ogasawara, K., Hamerman, J. A., Ehrlich, L. R., Bour-Jordan, H., Santamaria, P., Bluestone, J. A. and Lanier, L. L., NKG2D blockage prevents autoimmune diabetes in NOD mice. Immunity 2004 20: 757.
  • 33
    Tough, D. F. and Sprent, J., Turnover of native- and memory-phenotype T cells. J. Exp. Med. 1994 179: 1127.
  • 34
    Tough, D. F. and Sprent, J., Measurement of T and B cell turnover with bromodeoxyuridine. In: Coligan, J., Kruisbeek, A. M., Margulies, D. H., Shevach, E. M., and Strober, W. (Eds.), Current Protocols in Immunology, John Wiley and Sons, New York 2007 pp.