• 1
    Lazzeri, E. and Romagnani, P., CXCR3-binding chemokines: novel multifunctional therapeutic targets. Curr. Drug Targets Immune Endocr. Metabol. Disord. 2005. 5: 109118.
  • 2
    Luster, A. D., Greenberg, S. M. and Leder, P., The IP-10 chemokine binds to a specific cell surface heparan sulfate site shared with platelet factor 4 and inhibits endothelial cell proliferation. J. Exp. Med. 1995. 182: 219231.
  • 3
    Witko-Sarsat, V., Rieu, P., Descamps-Latscha, B., Lesavre, P. and Halbwachs-Mecarelli, L., Neutrophils: molecules, functions and pathophysiological aspects. Lab. Invest. 2000. 80: 617653.
  • 4
    Cassatella, M. A., Neutrophil-derived proteins: Selling cytokines by the pound. Adv Immunol. 1999. 73: 369509.
  • 5
    Cassatella, M. A., Gasperini, S., Calzetti, F., Bertagnin, A., Luster, A. D. and McDonald, P. P., Regulated production of the interferon-gamma-inducible protein-10 (IP-10) chemokine by human neutrophils. Eur. J. Immunol. 1997. 27: 111115.
  • 6
    Gasperini, S., Marchi, M., Calzetti, F., Laudanna, C., Vicentini, L., Olsen, H., Murphy, M. et al., Gene expression and production of the monokine induced by IFN--gamma (MIG), IFN--inducible T cell alpha chemoattractant (I-TAC), and IFN--gamma-inducible protein-10 (IP-10) chemokines by human neutrophils. J. Immunol. 1999. 162: 49284937.
  • 7
    Yamashiro, S., Kamohara, H. and Yoshimura, T., Alteration in the responsiveness to tumor necrosis factor-alpha is crucial for maximal expression of monocyte chemoattractant protein-1 in human neutrophils. Immunology 2000. 101: 97103.
  • 8
    Seiler, P., Aichele, P., Bandermann, S., Hauser, A. E., Lu, B., Gerard, N. P., Gerard, C. et al., Early granuloma formation after aerosol Mycobacterium tuberculosis infection is regulated by neutrophils via CXCR3-signaling chemokines. Eur. J. Immunol. 2003. 33: 26762686.
  • 9
    Molesworth-Kenyon, S. J., Oakes, J. E. and Lausch, R. N., A novel role for neutrophils as a source of T cell-recruiting chemokines IP-10 and Mig during the DTH response to HSV-1 antigen. J. Leukoc. Biol. 2005. 77: 552559.
  • 10
    Toshchakov, V., Jones, B. W., Perera, P. Y., Thomas, K., Cody, M. J., Zhang, S., Williams, B. R. et al., TLR4, but not TLR2, mediates IFN--beta-induced STAT1alpha/beta-dependent gene expression in macrophages. Nat. Immunol. 2002. 3: 392398.
  • 11
    Tamassia, N., V., L. M., Calzetti, F., Donini, M., Gasperini, S., Ear, T., Cloutier, A., Martinez, F. O. et al., The MyD88-independent pathway is not mobilized in human neutrophils stimulated via TLR4. J. Immunol. 2007. 178: 73447356.
  • 12
    Hirschfeld, M., Ma, Y., Weis, J. H., Vogel, S. N. and Weis, J. J., Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2. J. Immunol. 2000. 165: 618622.
  • 13
    Kurt-Jones, E. A., Mandell, L., Whitney, C., Padgett, A., Gosselin, K., Newburger, P. E. and Finberg, R. W., Role of toll-like receptor 2 (TLR2) in neutrophil activation: GM-CSF enhances TLR2 expression and TLR2-mediated interleukin 8 responses in neutrophils. Blood 2002. 100: 18601868.
  • 14
    Hayashi, F., Means, T. K. and Luster, A. D., Toll-like receptors stimulate human neutrophil function. Blood 2003. 102: 26602669.
  • 15
    Ohmori, Y. and Hamilton, T. A., The interferon-stimulated response element and a kappa B site mediate synergistic induction of murine IP-10 gene transcription by IFN--gamma and TNF-alpha. J. Immunol. 1995. 154: 52355244.
  • 16
    Doyle, S., Vaidya, S., O'Connell, R., Dadgostar, H., Dempsey, P., Wu, T., Rao, G. et al., IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity 2002. 17: 251263.
  • 17
    Holzberg, D., Knight, C. G., Dittrich-Breiholz, O., Schneider, H., Dorrie, A., Hoffmann, E., Resch, K. and Kracht, M., Disruption of the c-JUN-JNK complex by a cell-permeable peptide containing the c-JUN delta domain induces apoptosis and affects a distinct set of interleukin-1-induced inflammatory genes. J. Biol. Chem. 2003. 278: 4021340223.
  • 18
    Cloutier, A., Ear, T., Borissevitch, O., Larivee, P. and McDonald, P. P., Inflammatory cytokine expression is independent of the c-Jun N-terminal kinase/AP-1 signaling cascade in human neutrophils. J. Immunol. 2003. 171: 37513761.
  • 19
    McDonald, P. P., Bald, A. and Cassatella, M. A., Activation of the NF-kappaB pathway by inflammatory stimuli in human neutrophils. Blood 1997. 89: 34213433.
  • 20
    Palombella, V. J., Rando, O. J., Goldberg, A. L. and Maniatis, T., The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B. Cell 1994. 78: 773785.
  • 21
    Schreck, R., Meier, B., Mannel, D. N., Droge, W. and Baeuerle, P. A., Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells. J. Exp. Med. 1992. 175: 11811194.
  • 22
    Lin, Y. Z., Yao, S. Y., Veach, R. A., Torgerson, T. R. and Hawiger, J., Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. J. Biol. Chem. 1995. 270: 1425514258.
  • 23
    Kato, A., Ogasawara, T., Homma, T., Saito, H. and Matsumoto, K., Lipopolysaccharide-binding protein critically regulates lipopolysaccharide-induced IFN-beta signaling pathway in human monocytes. J. Immunol. 2004. 172: 61856194.
  • 24
    Liu, B., Mink, S., Wong, K. A., Stein, N., Getman, C., Dempsey, P. W., Wu, H. and Shuai, K., PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity. Nat. Immunol. 2004. 5: 891898.
  • 25
    Nazar, A. S., Cheng, G., Shin, H. S., Brothers, P. N., Dhib-Jalbut, S., Shin, M. L. and Vanguri, P., Induction of IP-10 chemokine promoter by measles virus: comparison with interferon-gamma shows the use of the same response element but with differential DNA-protein binding profiles. J. Neuroimmunol. 1997. 77: 116127.
  • 26
    Powell, J. D., Boodoo, S. and Horton, M. R., Identification of the molecular mechanism by which TLR ligation and IFN--gamma synergize to induce MIG. Clin. Dev. Immunol. 2004. 11: 7785.
  • 27
    Hiroi, M. and Ohmori, Y., Constitutive nuclear factor kappaB activity is required to elicit interferon-gamma-induced expression of chemokine CXC ligand 9 (CXCL9) and CXCL10 in human tumor cell lines. Biochem. J. 2003. 376: 393402.
  • 28
    Kim, M. O., Si, Q., Zhou, J. N., Pestell, R. G., Brosnan, C. F., Locker, J. and Lee, S. C., Interferon-beta activates multiple signaling cascades in primary human microglia. J. Neurochem. 2002. 81: 13611371.
  • 29
    Naka, T., Fujimoto, M., Tsutsui, H. and Yoshimura, A., Negative regulation of cytokine and TLR signalings by SOCS and others. Adv. Immunol. 2005. 87: 61122.
  • 30
    Crepaldi, L., Gasperini, S., Lapinet, J. A., Calzetti, F., Pinardi, C., Liu, Y., Zurawski, S. et al., Up-regulation of IL-10R1 expression is required to render human neutrophils fully responsive to IL-10. J. Immunol. 2001. 167: 23122322.
  • 31
    Cassatella, M. A., Flynn, R. M., Amezaga, M. A., Bazzoni, F., Vicentini, F. and Trinchieri, G., Interferon gamma induces in human neutrophils and macrophages expression of the mRNA for the high affinity receptor for monomeric IgG (Fc gamma R-I or CD64). Biochem. Biophys. Res. Commun. 1990. 170: 582588.
  • 32
    Cassatella, M. A., Huber, V., Calzetti, F., Margotto, D., Tamassia, N., Peri, G., Mantovani, A. et al., Interferon-activated neutrophils store a TNF-related apoptosis-inducing ligand (TRAIL/Apo-2 ligand) intracellular pool that is readily mobilizable following exposure to proinflammatory mediators. J. Leukoc. Biol. 2006. 79: 123132.
  • 33
    Bradley, M. N., Zhou, L. and Smale, S. T., C/EBPbeta regulation in lipopolysaccharide-stimulated macrophages. Mol. Cell. Biol. 2003. 23: 48414858.
  • 34
    Dignam, J. D., Lebovitz, R. M. and Roeder, R. G., Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 1983. 11: 14751489.
  • 35
    McDonald, P. P., Bovolenta, C. and Cassatella, M. A., Activation of distinct transcription factors in neutrophils by bacterial LPS, interferon-gamma, and GM-CSF and the necessity to overcome the action of endogenous proteases. Biochemistry 1998. 37: 1316513173.