• 1
    Trinchieri, G., Pflanz, S. and Kastelein, R. A., The IL-12 family of heterodimeric cytokines: New players in the regulation of T cell responses. Immunity 2003. 19: 641644.
  • 2
    Bettelli, E. and Kuchroo, V. K., IL-12- and IL-23-induced T helper cell subsets: Birds of the same feather flock together. J. Exp. Med. 2005. 201: 169171.
  • 3
    Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M. and Stockinger, B., TGF-β in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006. 24: 179189.
  • 4
    Stockinger, B. and Veldhoen, M., Differentiation and function of Th17 T cells. Curr. Opin. Immunol. 2007. 19: 281286.
  • 5
    Dong, C., Diversification of T-helper-cell lineages: Finding the family root of IL-17-producing cells. Nat. Rev. Immunol. 2006. 6: 329333.
  • 6
    Harrington, L. E., Mangan, P. R. and Weaver, C. T., Expanding the effector CD4 T-cell repertoire: The Th17 lineage. Curr. Opin. Immunol. 2006. 18: 349356.
  • 7
    Happel, K. I., Dubin, P. J., Zheng, M., Ghilardi, N., Lockhart, C., Quinton, L. J., Odden, A. R. et al., Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. J. Exp. Med. 2005. 202: 761769.
  • 8
    Hunter, C. A., New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat. Rev. Immunol. 2005. 5: 521531.
  • 9
    Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D. et al., Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 2006. 441: 231234.
  • 10
    Romani, L., Immunity to fungal infections. Nat. Rev. Immunol. 2004. 4: 123.
  • 11
    Ryan, K. R., Lawson, C. A., Lorenzi, A. R., Arkwright, P. D., Isaacs, J. D. and Lilic, D., CD4+CD25+ T-regulatory cells are decreased in patients with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy. J. Allergy Clin. Immunol. 2005. 116: 11581159.
  • 12
    Lilic, D., New perspectives on the immunology of chronic mucocutaneous candidiasis. Curr. Opin. Infect. Dis. 2002. 15: 143147.
  • 13
    Ortega, M., Rovira, M., Filella, X., Martinez, J. A., Almela, M., Puig, J., Carreras, E. and Mensa, J., Prospective evaluation of procalcitonin in adults with non-neutropenic fever after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2006. 37: 499502.
  • 14
    Netea, M. G., Sutmuller, R., Hermann, C., Van der Graaf, C. A., Van der Meer, J. W., van Krieken, J. H., Hartung, T. et al., Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells. J. Immunol. 2004. 172: 37123718.
  • 15
    Romani, L. and Puccetti, P., Protective tolerance to fungi: The role of IL-10 and tryptophan catabolism. Trends Microbiol. 2006. 14: 183189.
  • 16
    Hohl, T. M., Rivera, A. and Pamer, E. G., Immunity to fungi. Curr. Opin. Immunol. 2006. 18: 465472.
  • 17
    Leibundgut-Landmann, S., Gross, O., Robinson, M. J., Osorio, F., Slack, E. C., Tsoni, S. V., Schweighoffer, E. et al., Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat. Immunol. 2007. 8: 630638.
  • 18
    Acosta-Rodriguez, E. V., Rivino, L., Geginat, J., Jarrossay, D., Gattorno, M., Lanzavecchia, A., Sallusto, F. and Napolitani, G., Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat. Immunol. 2007. 8: 639646.
  • 19
    Khader, S. A., Pearl, J. E., Sakamoto, K., Gilmartin, L., Bell, G. K., Jelley-Gibbs, D. M., Ghilardi, N. et al., IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-γ responses if IL-12p70 is available. J. Immunol. 2005. 175: 788795.
  • 20
    Gafa, V., Lande, R., Gagliardi, M. C., Severa, M., Giacomini, E., Remoli, M. E., Nisini, R. et al., Human dendritic cells following Aspergillus fumigatus infection express the CCR7 receptor and a differential pattern of interleukin-12 (IL-12), IL-23, and IL-27 cytokines, which lead to a Th1 response. Infect. Immun. 2006. 74: 14801489.
  • 21
    Romani, L., Bistoni, F., Perruccio, K., Montagnoli, C., Gaziano, R., Bozza, S., Bonifazi, P. et al., Thymosin α1 activates dendritic cell tryptophan catabolism and establishes a regulatory environment for balance of inflammation and tolerance. Blood 2006. 108: 22652274.
  • 22
    Bellocchio, S., Moretti, S., Perruccio, K., Fallarino, F., Bozza, S., Montagnoli, C., Mosci, P. et al., TLRs govern neutrophil activity in aspergillosis. J. Immunol. 2004. 173: 74067415.
  • 23
    Yao, Z., Fanslow, W. C., Seldin, M. F., Rousseau, A. M., Painter, S. L., Comeau, M. R., Cohen, J. I. and Spriggs, M. K., Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity 1995. 3: 811821.
  • 24
    Bozza, S., Fallarino, F., Pitzurra, L., Zelante, T., Montagnoli, C., Bellocchio, S., Mosci, P. et al., A crucial role for tryptophan catabolism at the host/Candida albicans interface. J. Immunol. 2005. 174: 29102918.
  • 25
    Kolls, J. K. and Linden, A., Interleukin-17 family members and inflammation. Immunity 2004. 21: 467476.
  • 26
    Cua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L. et al., Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003. 421: 744748.
  • 27
    Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T. et al., IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 2005. 201: 233240.
  • 28
    Mellor, A. L. and Munn, D. H., IDO expression by dendritic cells: Tolerance and tryptophan catabolism. Nat. Rev. Immunol. 2004. 4: 762774.
  • 29
    Ye, P., Rodriguez, F. H., Kanaly, S., Stocking, K. L., Schurr, J., Schwarzenberger, P., Oliver, P. et al., Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J. Exp. Med. 2001. 194: 519527.
  • 30
    Linden, A., Laan, M. and Anderson, G. P., Neutrophils, interleukin-17A and lung disease. Eur. Respir. J. 2005. 25: 159172.
  • 31
    Huang, W., Na, L., Fidel, P. L. and Schwarzenberger, P., Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. J. Infect. Dis. 2004. 190: 624631.
  • 32
    Cruz, A., Khader, S. A., Torrado, E., Fraga, A., Pearl, J. E., Pedrosa, J., Cooper, A. M. and Castro, A. G., Cutting Edge: IFN-γ regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection. J. Immunol. 2006. 177: 14161420.
  • 33
    Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y. H., Wang, Y. et al., A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 2005. 6: 11331141.
  • 34
    Becker, C., Dornhoff, H., Neufert, C., Fantini, M. C., Wirtz, S., Huebner, S., Nikolaev, A. et al., Cutting Edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis. J. Immunol. 2006. 177: 27602764.
  • 35
    Kullberg, M. C., Jankovic, D., Feng, C. G., Hue, S., Gorelick, P. L., McKenzie, B. S., Cua, D. J. et al., IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. J. Exp. Med. 2006. 203: 24852494.
  • 36
    Kleinschek, M. A., Muller, U., Brodie, S. J., Stenzel, W., Kohler, G., Blumenschein, W. M., Straubinger, R. K. et al., IL-23 enhances the inflammatory cell response in Cryptococcus neoformans infection and induces a cytokine pattern distinct from IL-12. J. Immunol. 2006. 176: 10981106.
  • 37
    McKenzie, B. S., Kastelein, R. A. and Cua, D. J., Understanding the IL-23-IL-17 immune pathway. Trends Immunol. 2006. 27: 1723.
  • 38
    Montagnoli, C., Bacci, A., Bozza, S., Gaziano, R., Mosci, P., Sharpe, A. H. and Romani, L., B7/CD28-dependent CD4+CD25+ regulatory T cells are essential components of the memory-protective immunity to Candida albicans. J. Immunol. 2002. 169: 62986308.
  • 39
    Montagnoli, C., Fallarino, F., Gaziano, R., Bozza, S., Bellocchio, S., Zelante, T., Kurup, W. P. et al., Immunity and tolerance to Aspergillus involve functionally distinct regulatory T cells and tryptophan catabolism. J. Immunol. 2006. 176: 17121723.
  • 40
    Belladonna, M. L., Vacca, C., Volpi, C., Giampietri, A., Fioretti, M. C., Puccetti, P., Grohmann, U. and Campanile, F., IL-23 neutralization protects mice from gram-negative endotoxic shock. Cytokine 2006. 34: 161169.
  • 41
    Bellocchio, S., Montagnoli, C., Bozza, S., Gaziano, R., Rossi, G., Mambula, S. S., Vecchi, A. et al., The contribution of the Toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo. J. Immunol. 2004. 172: 30593069.