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  • 1
    Sakaguchi, S., Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. 2005. 6: 345352.
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    Baecher-Allan, C. and Hafler, D. A., Suppressor T cells in human diseases. J. Exp. Med. 2004. 200: 273276.
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    Viglietta, V., Baecher-Allan, C., Weiner, H. L. and Hafler, D. A., Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J. Exp. Med. 2004. 199: 971979.
  • 4
    Kriegel, M. A., Lohmann, T., Gabler, C., Blank, N., Kalden, J. R. and Lorenz, H. M., Defective suppressor function of human CD4+CD25+ regulatory T cells in autoimmune polyglandular syndrome type II. J. Exp. Med. 2004. 199: 12851291.
  • 5
    Huan, J., Culbertson, N., Spencer, L., Bartholomew, R., Burrows, G. G., Chou, Y. K., Bourdette, D. et al., Decreased FOXP3 levels in multiple sclerosis patients. J. Neurosci. Res. 2005. 81: 4552.
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    Offner, H. and Vandenbark, A. A., Congruent effects of estrogen and T-cell receptor peptide therapy on regulatory T cells in EAE and MS. Int. Rev. Immunol. 2005. 24: 447477.
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    Venken, K., Hellings, N., Hensen, K., Rummens, J. L., Medaer, R., D'Hooghe M, B., Dubois, B. et al., Secondary progressive in contrast to relapsing-remitting multiple sclerosis patients show a normal CD4+CD25+ regulatory T-cell function and FOXP3 expression. J. Neurosci. Res. 2006. 83: 14321446.
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    Takahashi, M., Nakamura, K., Honda, K., Kitamura, Y., Mizutani, T., Araki, Y., Kabemura, T. et al., An inverse correlation of human peripheral blood regulatory T cell frequency with the disease activity of ulcerative colitis. Dig. Dis. Sci. 2006. 51: 677686.
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    Schaefer, C., Kim, G. G., Albers, A., Hoermann, K., Myers, E. N. and Whiteside, T. L., Characteristics of CD4+CD25+ regulatory T cells in the peripheral circulation of patients with head and neck cancer. Br. J. Cancer 2005. 92: 913920.
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    Ormandy, L. A., Hillemann, T., Wedemeyer, H., Manns, M. P., Greten, T. F. and Korangy, F., Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma. Cancer Res. 2005. 65: 24572464.
  • 11
    Cesana, G. C., DeRaffele, G., Cohen, S., Moroziewicz, D., Mitcham, J., Stoutenburg, J., Cheung, K. et al., Characterization of CD4+CD25+ regulatory T cells in patients treated with high-dose interleukin-2 for metastatic melanoma or renal cell carcinoma. J. Clin. Oncol. 2006. 24: 11691177.
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    Zou, W., Regulatory T cells, tumour immunity and immunotherapy. Nat. Rev. Immunol. 2006. 6: 295307.
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    Curiel, T. J., Coukos, G., Zou, L., Alvarez, X., Cheng, P., Mottram, P., Evdemon-Hogan, M. et al., Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat. Med. 2004. 10: 942949.
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    Wolf, D., Wolf, A. M., Rumpold, H., Fiegl, H., Zeimet, A. G., Muller-Holzner, E., Deibl, M. et al., The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer. Clin. Cancer Res. 2005. 11: 83268331.
  • 15
    Beyer, M., Kochanek, M., Giese, T., Endl, E., Weihrauch, M. R., Knolle, P. A., Classen, S. and Schultze, J. L., In vivo peripheral expansion of naive CD4+CD25high FOXP3+ regulatory T cells in patients with multiple myeloma. Blood 2006. 107: 39403949.
  • 16
    Clarke, S., Bett, G. J., Plant, A., Wright, K. L., El-Shanawany, T. M., Harrop, R., Torkington, J. et al., CD4+CD25+FOXP3+ regulatory T cells suppress anti-tumor immune responses in patients with colorectal cancer. PLoS One 2006. 1: e129.
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    Curiel, T. J., Tregs and rethinking cancer immunotherapy. J. Clin. Invest. 2007. 117: 11671174.
  • 18
    Bates, G. J., Fox, S. B., Han, C., Leek, R. D., Garcia, J. F., Harris, A. L. and Banham, A. H., Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse. J. Clin. Oncol. 2006. 24: 53735380.
  • 19
    Zheng, Y. and Rudensky, A. Y., Foxp3 in control of the regulatory T cell lineage. Nat. Immunol. 2007. 8: 457462.
  • 20
    Fontenot, J. D., Rasmussen, J. P., Williams, L. M., Dooley, J. L., Farr, A. G. and Rudensky, A. Y., Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 2005. 22: 329341.
  • 21
    Wan, Y. Y. and Flavell, R. A., Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proc. Natl. Acad. Sci. USA 2005. 102: 51265131.
  • 22
    Lahl, K., Loddenkemper, C., Drouin, C., Freyer, J., Arnason, J., Eberl, G., Hamann, A. et al., Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J. Exp. Med. 2007. 204: 5763.
  • 23
    Walker, M. R., Kasprowicz, D. J., Gersuk, V. H., Benard, A., Van Landeghen, M., Buckner, J. H. and Ziegler, S. F., Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25 T cells. J. Clin. Invest. 2003. 112: 14371443.
  • 24
    Yagi, H., Nomura, T., Nakamura, K., Yamazaki, S., Kitawaki, T., Hori, S., Maeda, M. et al., Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells. Int. Immunol. 2004. 16: 16431656.
  • 25
    Roncador, G., Brown, P. J., Maestre, L., Hue, S., Martinez-Torrecuadrada, J. L., Ling, K. L., Pratap, S. et al., Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level. Eur. J. Immunol. 2005. 35: 16811691.
  • 26
    Ziegler, S. F., FOXP3: Not just for regulatory T cells anymore. Eur. J. Immunol. 2007. 37: 2123.
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    Morgan, M. E., van Bilsen, J. H., Bakker, A. M., Heemskerk, B., Schilham, M. W., Hartgers, F. C., Elferink, B. G. et al., Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans. Hum. Immunol. 2005. 66: 1320.
  • 28
    Mantel, P. Y., Ouaked, N., Ruckert, B., Karagiannidis, C., Welz, R., Blaser, K. and Schmidt-Weber, C. B., Molecular mechanisms underlying FOXP3 induction in human T cells. J. Immunol. 2006. 176: 35933602.
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    Gavin, M. A., Torgerson, T. R., Houston, E., Deroos, P., Ho, W. Y., Stray-Pedersen, A., Ocheltree, E. L. et al., Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc. Natl. Acad. Sci. USA 2006. 103: 66596664.
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    Wang, J., Ioan-Facsinay, A., van der Voort, E. I. H., Huizinga, T. W. J. and Toes, R. E. M., Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells. Eur. J. Immunol. 2007. 37: 129138.
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    Pillai, V., Ortega, S. B., Wang, C. K. and Karandikar, N. J., Transient regulatory T-cells: A state attained by all activated human T-cells. Clin. Immunol. 2007. 123: 1829.
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    Allan, S. E., Crome, S. Q., Crellin, N. K., Passerini, L., Steiner, T. S., Bacchetta, R., Roncarolo, M. G. and Levings, M. K., Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. Int. Immunol. 2007. 19: 345354.
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    Floess, S., Freyer, J., Siewert, C., Baron, U., Olek, S., Polansky, J., Schlawe, K. et al., Epigenetic control of the foxp3 locus in regulatory T cells. PLOS Biol 2007. 5: e38.
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    Reik, W., Dean, W. and Walter, J., Epigenetic reprogramming in mammalian development. Science 2001. 293: 10891093.
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    Bird, A., DNA methylation patterns and epigenetic memory. Genes Dev. 2002. 16: 621.
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    Baron, U., Türbachova, I., Hellwag, A., Eckhardt, F., Berlin, K., Hoffmuller, U., Gardina, P. and Olek, S., DNA methylation analysis as a tool for cell typing. Epigenetics 2006. 1: 5560.
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    Eckhardt, F., Lewin, J., Cortese, R., Rakyan, V. K., Attwood, J., Burger, M., Burton, J. et al., DNA methylation profiling of human chromosomes 6, 20 and 22. Nat. Genet. 2006. 38: 13781385.
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    Carrel, L. and Willard, H. F., X-inactivation profile reveals extensive variability in X-linked gene expression in females. Nature 2005. 434: 400404.
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    Huang, T. H., Perry, M. R. and Laux, D. E., Methylation profiling of CpG islands in human breast cancer cells. Hum. Mol. Genet. 1999. 8: 459470.
  • 40
    Wahl, S. M. and Chen, W., Transforming growth factor-beta-induced regulatory T cells referee inflammatory and autoimmune diseases. Arthritis Res. Ther. 2005. 7: 6268.
  • 41
    Hoffmann, P., Eder, R., Boeld, T. J., Doser, K., Piseshka, B., Andreesen, R. and Edinger, M., Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. Blood 2006. 108: 42604267.
  • 42
    Zuo, T., Wang, L., Morrison, C., Chang, X., Zhang, H., Li, W., Liu, Y. et al., FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene. Cell 2007. 129: 12751286.
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    Bouche, N., Scharlat, A., Snedden, W., Bouchez, D. and Fromm, H., A novel family of calmodulin-binding transcription activators in multicellular organisms. J. Biol. Chem. 2002. 277: 2185121861.
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    Katoh, M. and Katoh, M., Identification and characterization of FLJ10737 and CAMTA1 genes on the commonly deleted region of neuroblastoma at human chromosome 1p36.31-p36.23. Int. J. Oncol. 2003. 23: 12191224.
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    Nakatani, K., Nishioka, J., Itakura, T., Nakanishi, Y., Horinouchi, J., Abe, Y., Wada, H. and Nobori, T., Cell cycle-dependent transcriptional regulation of calmodulin-binding transcription activator 1 in neuroblastoma cells. Int. J. Oncol. 2004. 24: 14071412.
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    Henrich, K. O., Fischer, M., Mertens, D., Benner, A., Wiedemeyer, R., Brors, B., Oberthuer, A. et al., Reduced expression of CAMTA1 correlates with adverse outcome in neuroblastoma patients. Clin. Cancer Res. 2006. 12: 131138.
  • 47
    Huehn, J., Siegmund, K., Lehmann, J., Siewert, C., Haubold, U., Feuerer, M., Debes, G. F. et al., Developmental stage, phenotype and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells. J. Exp. Med. 2004. 199: 303313.
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    Olek, A., Oswald, J. and Walter, J., A modified and improved method for bisulphite based cytosine methylation analysis. Nucleic Acids Res. 1996. 24: 50645066.
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    Lewin, J., Schmitt, A. O., Adorjan, P., Hildmann, T. and Piepenbrock, C., Quantitative DNA methylation analysis based on four-dye trace data from direct sequencing of PCR amplificates. Bioinformatics 2004. 20: 30053012.