• 1
    Fox, J. G. and Wang, T. C., Inflammation, atrophy, and gastric cancer. J. Clin. Invest. 2007 117: 6069.
  • 2
    Ernst, P. B. and Gold, B. D., The disease spectrum of Helicobacter pylori: The immunopathogenesis of gastroduodenal ulcer and gastric cancer. Annu. Rev. Microbiol. 2000 54: 615640.
  • 3
    D'Elios, M. M., Vanghetti, M., De Carli, M., Costa, F., Baldari, C. T., Burroni, D., Telford, J. L. et al., T helper 1 effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease. J. Immunol. 1997 158: 962967.
  • 4
    Kolls, J. K. and Linden, A., Interleukin-17 family members and inflammation. Immunity 2004 21: 467476.
  • 5
    Steinman, L., A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage. Nat. Med. 2007 13: 13911345.
  • 6
    Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y. H., Wang, Y. et al., A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 2005 6: 11331141.
  • 7
    Weaver, C. T., Hatton, R. D., Mangan, P. R., Harrington, L. E., IL-17 Family cytokines and the expanding diversity of effector T cell lineages. Annu. Rev. Immunol. 2007 25: 821852.
  • 8
    Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M. and Weaver, C. T., Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 2005 6: 11231132.
  • 9
    Luzza, F., Carrello, T., Monteleone, G., Sebkova, L., Romano, M., Zarrilli, R., Imeneo, M. et al., Up-regulation of IL-17 is associated with bioactive IL-8 expression in Helicobacter pylori-infected human gastric mucosa. J. Immunol. 2000 165: 53325337.
  • 10
    Mizuno, T., Ando, T., Nobata, K., Tsuzuki, T., Maeda, O., Watanabe, O., Minami, M. et al., Interleukin-17 levels in Helicobacter pylori-infected gastric mucosa and pathologic sequelae of colonization. World J. Gastroenterol. 2005 11: 63056311.
  • 11
    Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L. et al., Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006 441: 235238.
  • 12
    Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D. et al., Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 2006 441: 231234.
  • 13
    Oppmann, B., Lesley, R., Blom, B., Timans, J. C., Xu, Y., Hunte, B., Vega, F. et al., Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 2000 13: 715725.
  • 14
    Zhang, X. Y., Zhang, H. J., Zhang, Y., Fu, J., He, J., Zhu, L. P., Wang, S. H. et al., Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cells. Immunogenetics 2006 57: 934943.
  • 15
    Ghilardi, N., Kljavin, N., Chen, Q., Lucas, S., Gurney, A. L. and De Sauvage, F. J., Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice. J. Immunol. 2004 172: 28272833.
  • 16
    Lindholm, C., Quiding-Jarbrink, M., Lonroth, H., Hamlet, A. and Svennerholm, A. M., Local cytokine response in Helicobacter pylori-infected subjects. Infect. Immun. 1998 66: 59645971.
  • 17
    Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T. et al., IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 2005 201: 233240.
  • 18
    Verreck, F. A., De Boer, T., Langenberg, D. M., Hoeve, M. A., Kramer, M., Vaisberg, E., Kastelein, R. et al., Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria. Proc. Natl. Acad. Sci. USA 2004 101: 45604565.
  • 19
    Cho, M. L., Kang, J. W., Moon, Y. M., Nam, H. J., Jhun, J. Y., Heo, S. B., Jin, H. T. et al., STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice. J. Immunol. 2006 176: 56525661.
  • 20
    Darnell, J. E. Jr., Kerr, I. M., Stark, G. R., Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994 264: 14151421.
  • 21
    Platanias, L. C., Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat. Rev. Immunol. 2005 5: 375386.
  • 22
    Annunziato, F., Cosmi, L., Santarlasci, V., Maggi, L., Liotta, F., Mazzinghi, B., Parente, E. et al., Phenotypic and functional features of human Th17 cells. J. Exp. Med. 2007 204: 18491861.
  • 23
    Mitchell, P., Germain, C., Fiori, P. L., Khamri, W., Foster, G. R., Ghosh, S., Lechler, R. I. et al., Chronic exposure to Helicobacter pylori impairs dendritic cell function and inhibits Th1 development. Infect. Immun. 2007 75: 810819.
  • 24
    Amedei, A., Cappon, A., Codolo, G., Cabrelle, A., Polenghi, A., Benagiano, M., Tasca, E. et al., The neutrophil-activating protein of Helicobacter pylori promotes Th1 immune responses. J. Clin. Invest. 2006 116: 10921101.
  • 25
    Lankford, C. S. R. and Frucht, D. M., A unique role for IL-23 in promoting cellular immunity. J. Leukoc. Biol. 2003 73:4956.
  • 26
    Hunter, C. A., New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat. Rev. Immunol. 2005 5: 521531.
  • 27
    Aggarwal, S., Ghilardi, N., Xie, M. H., De Sauvage, F. J. and Gurney, A. L., Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J. Biol. Chem. 2003 278: 19101914.
  • 28
    Bauditz, J., Ortner, M., Bierbaum, M., Niedobitek, G., Lochs, H. and Schreiber, S., Production of IL-12 in gastritis relates to infection with Helicobacter pylori. Clin. Exp. Immunol. 1999 117: 316323.
  • 29
    Sutton, C., Brereton, C., Keogh, B., Mills, H. and Lavelle, E. C., A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J. Exp. Med. 2006 203: 16851691.
  • 30
    Ferretti, S., Bonneau, O., Dubois, G. R., Jones, C. E. and Trifilieff, A., IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger. J. Immunol. 2003 170: 21062112.
  • 31
    Luzza, F., Carrello, T., Monteleone, G., Sebkova, L., Imeneo, M., La Vecchia, A., Maletta, M. et al., Changes in the mucosal expression of interleukin 15 in Helicobacter pylori-associated gastritis. FEMS Immunol. Med. Microbiol. 1999 24: 233238.
  • 32
    Yang, X. O., Panopoulos, A. D., Nurieva, R., Chang, S. H., Wang, D., Watowich, S. S. and Dong, C., STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J. Biol. Chem. 2007 282: 93589363.
  • 33
    Chen, Z., Laurence, A., Kanno, Y., Pacher-Zavisin, M., Zhu, B. M., Tato, C., Yoshimura, A. et al., Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. Proc. Natl. Acad. Sci. USA 2006 103: 81378142.
  • 34
    Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J. et al., The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 2006 126: 11211133.
  • 35
    Kullberg, M. C., Jankovic, D., Feng, C. G., Hue, S., Gorelick, P. L., McKenzie, B. S., Cua, D. J. et al., IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. J. Exp. Med. 2006 203: 24852494.
  • 36
    Chu, S. H., Kim, H., Seo, J. Y., Lim, J. W., Mukaida, N. and Kim, K. H., Role of NF-kappaB and AP-1 on Helicobacter pylori-induced IL-8 expression in AGS cells. Dig. Dis. Sci. 2003 48: 257265.
  • 37
    Eaton, K. A., Ringler, S. R. and Danon, S. J., Murine splenocytes induce severe gastritis and delayed-type hypersensitivity and suppress bacterial colonization in Helicobacter pylori-infected SCID mice. Infect. Immun. 1999 67: 45944602.
  • 38
    Sebkova, L., Pellicano, A., Monteleone, G., Grazioli, B., Guarnirei, G., Imeneo, M., Pallone, F. and Luzza, F., Extracellular signal-regulated protein kinase mediates interleukin 17 (IL-17)-induced IL-8 secretion in Helicobacter pylori-infected human gastric epithelial cells. Infect. Immun. 2004 72: 50195026.
  • 39
    Bamba, S., Andoh, A., Yasui, H., Araki, Y., Bamba, T. and Fujiyama, Y., Matrix metalloproteinase-3 secretion from human colonic subepithelial myofibroblasts: Role of interleukin-17. J. Gastroenterol. 2003 38: 548554.