Innate responses of B cells

Authors

  • David Gray Dr.,

    Corresponding author
    1. Institute of Immunology and Infection Research, University of Edinburgh, Ashworth Labs, Edinburgh, UK
    • Institute of Immunology & Infection Research, University of Edinburgh, Ashworth Labs, King's Buildings, West Mains Road, Edinburgh, EH9 3JT, UK, Fax: +44-131-650-7322
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  • Mohini Gray,

    1. MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK
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  • Tom Barr

    1. Institute of Immunology and Infection Research, University of Edinburgh, Ashworth Labs, Edinburgh, UK
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Abstract

In this review, we describe the non-antibody-mediated functions of B cells within the immune system. In addition to antibody production, B cells also present antigen to T cells, programme T cell differentiation and regulate effector T cell responses and much of this is mediated by the cytokines they make. We focus on the potential of B cells to perform these functions simply as a result of activation via ‘innate’ receptors (e.g. Toll-like receptors) and often independently of BCR ligation. We feel an appreciation of these broad and often antigen-nonspecific functions is important at a time when there is an increasing use of B cell depletion as a therapy for autoimmune disease.

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