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IL-23 and IL-17 have a multi-faceted largely negative role in fungal infection

  1. Andrea M. Cooper*

Article first published online: 26 SEP 2007

DOI: 10.1002/eji.200737804

Issue

European Journal of Immunology

European Journal of Immunology

Volume 37, Issue 10, pages 2680–2682, October 2007

Additional Information

How to Cite

Cooper, Andrea M. (2007), IL-23 and IL-17 have a multi-faceted largely negative role in fungal infection. Eur. J. Immunol., 37: 2680–2682. doi: 10.1002/eji.200737804

Author Information

  1. Trudeau Institute, Saranac Lake, New York, USA

*Trudeau Institute, 154 Algonquin Ave, Saranac Lake, NY12983, USA, Fax: +1-518-891-5126

Publication History

  1. Issue published online: 26 SEP 2007
  2. Article first published online: 26 SEP 2007
  3. Manuscript Accepted: 5 SEP 2007
  4. Manuscript Received: 3 SEP 2007

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  • 1
    Acosta-Rodriguez, E., Rivino, L., Geginat, J., Jarrossay, D., Gattorno, M., Lanzavecchia, A., Sallusto, F. and Napolitani, G., Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat. Immunol. 2007. 8: 639–646.
  • 2
    Leibundgut-Landmann, S., Groß, O., Robinson, M., Osorio, F., Slack, E., Tsoni, S., Schweighoffer, E. et al., Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat. Immunol. 2007. 8: 630–638.
  • 3
    Veldhoen, M., Hocking, R., Atkins, C., Locksley, R. and Stockinger, B., TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006. 24: 179–189.
  • 4
    Palm, N. and Medzhitov, R., Antifungal defense turns 17. Nat. Immunol. 2007. 8: 549–551.
  • 5
    Zelante, T., De Luca, A., Bonifazi, P., Montagnoli, C., Bozza, S., Moretti, S., Belladonna, M. L. et al., L-23 and the Th17 pathway promote inflammation and inpair anti-fungl immune resistance. Eur. J. Immunol. 2007. 37: DOI 10.1002/eji.200737409
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  • 6
    Stockinger, B. and Veldhoen, M., Differentiation and function of Th17 T cells. Curr. Op. Immunol. 2007. 19: 281–286.
  • 7
    Huang, W., Na, L., Fidel, P. and Schwarzenberger, P., Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. J. Inf. Dis. 2004. 190: 624–631.
  • 8
    Miyamoto, M., Prause, O., Sjostrand, M., Laan, M., Lotvall, J. and Linden, A., Endogenous IL-17 as a mediator of neutrophil recruitment caused by endotoxin exposure in mouse airways. J. Immunol. 2003. 170: 4665–4672.
  • 9
    Stark, M., Huo, Y., Burcin, T., Morris, M., Olson, T. and Ley, K., Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. Immunity 2005. 22: 285–294.
  • 10
    Hohl, T., Van Epps, H., Rivera, A., Morgan, L., Chen, P., Feldmesser, M. and Pamer, E., Aspergillus fumigatus triggers inflammatory responses by stage-specific beta-glucan display. PLoS Pathog 2005. 1: e30.
  • 11
    Steele, C., Rapaka, R., Metz, A., Pop, S., Williams, D., Gordon, S., Kolls, J. and Brown, G., The beta-glucan receptor dectin-1 recognizes specific morphologies of Aspergillus fumigatus. PLoS Pathog 2005. 1: e42.
  • 12
    Dragon, S., Saffar, A., Shan, L. and Gounni, A., IL-17 attenuates the anti-apoptotic effects of GM-CSF in human neutrophils. Mol. Immunol. 2007. epub.
  • 13
    Bozza, S., Fallarino, F., Pitzurra, L., Zelante, T., Montagnoli, C., Bellocchio, S., Mosci, P. et al., A crucial role for tryptophan catabolism at the host/Candida albicans interface. J. Immunol. 2005. 174: 2910–2918.
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