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Viewpoints on NK cells
Tolerance and reactivity of NK cells: Two sides of the same coin?
Article first published online: 31 OCT 2008
DOI: 10.1002/eji.200838755
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Held, W. (2008), Tolerance and reactivity of NK cells: Two sides of the same coin?. Eur. J. Immunol., 38: 2930–2933. doi: 10.1002/eji.200838755
Publication History
- Issue published online: 7 NOV 2008
- Article first published online: 31 OCT 2008
- Manuscript Accepted: 26 AUG 2008
- Manuscript Received: 25 JUL 2008
Funded by
- Oncosuisse
- Swiss National Science Foundation
- Abstract
- Article
- References
- Cited By
Keywords:
- Arming;
- Education;
- Licensing;
- NK cells;
- Tolerance
Abstract
NK cells can kill transformed, infected and stressed cells while most normal cells are spared. NK cells are activated by various endogenous self-ligands, some of which are actually expressed by normal cells. Thus, NK cells are inherently self-reactive and consequently, potentially auto-aggressive. How these cells are prevented from attacking normal cells while ensuring reactivity to diseased cells is a major unresolved question for NK-cell biologists.