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Viewpoints on NK cells
Beyond licensing and disarming: A quantitative view on NK-cell education
Article first published online: 31 OCT 2008
DOI: 10.1002/eji.200838760
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Brodin, P. and Höglund, P. (2008), Beyond licensing and disarming: A quantitative view on NK-cell education. Eur. J. Immunol., 38: 2934–2937. doi: 10.1002/eji.200838760
Publication History
- Issue published online: 7 NOV 2008
- Article first published online: 31 OCT 2008
- Manuscript Accepted: 8 SEP 2008
- Manuscript Revised: 31 AUG 2008
- Manuscript Received: 27 JUL 2008
Funded by
- Swedish Cancer Society
- The Swedish Research Council
- Karolinska Institutet
- Swedish Foundation for Strategic Research
- Abstract
- Article
- References
- Cited By
Keywords:
- Education;
- NK cell;
- Quantitative;
- Reversibility;
- Tolerance
Abstract
In this article, we will move beyond the current controversy of different models for NK-cell education and instead discuss the properties characterizing MHC class I-guided functional development of NK cells. We will argue that this development, which represents the endpoint of NK-cell education, is a quantitative and dynamic, and perhaps even reversible, process.