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Viewpoints on NK cells
Can NK cells be a therapeutic target in human diseases?
Article first published online: 31 OCT 2008
DOI: 10.1002/eji.200838764
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Chan, C. J., Andrews, D. M. and Smyth, M. J. (2008), Can NK cells be a therapeutic target in human diseases?. Eur. J. Immunol., 38: 2964–2968. doi: 10.1002/eji.200838764
Publication History
- Issue published online: 7 NOV 2008
- Article first published online: 31 OCT 2008
- Manuscript Accepted: 26 AUG 2008
- Manuscript Revised: 25 AUG 2008
- Manuscript Received: 28 JUL 2008
Funded by
- National Health and Medical Research Council (NHMRC) of Australia
- Doherty Fellowship
- Leukaemia Foundation of Australia
- Abstract
- Article
- References
- Cited By
Keywords:
- Cancer;
- Immunosurveillance;
- NK cells;
- Therapy
Abstract
Our current knowledge of NK-cell recognition and effector function suggests that it will be possible to design various new NK-cell-based immunotherapies against human cancer. The application of NK cells is already showing promise using HLA-mismatched haematopoietic stem cell transplantation for treatment of haematological malignancies. A better understanding of NK-cell heterogeneity and function will only broaden the applications for human cancer. Here we review the key developments that will propel this field.