Viewpoints on NK cells

Viral inhibitors of NKG2D ligands: Friends or foes of immune surveillance?

  1. Stipan Jonjić*,
  2. Bojan Polić,
  3. Astrid Krmpotić

Article first published online: 31 OCT 2008

DOI: 10.1002/eji.200838823

Issue

European Journal of Immunology

European Journal of Immunology

Volume 38, Issue 11, pages 2952–2956, November 2008

Additional Information

How to Cite

Jonjić, S., Polić, B. and Krmpotić, A. (2008), Viral inhibitors of NKG2D ligands: Friends or foes of immune surveillance?. Eur. J. Immunol., 38: 2952–2956. doi: 10.1002/eji.200838823

Author Information

  1. Faculty of Medicine University of Rijeka, Brace Branchetta 20 Rijeka, Croatia

*Dr. Stipan Jonjic, Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, Brace Branchetta 20, 51000 Rijeka, Croatia Fax: +385-51-651-176

Publication History

  1. Issue published online: 7 NOV 2008
  2. Article first published online: 31 OCT 2008
  3. Manuscript Accepted: 26 AUG 2008
  4. Manuscript Revised: 25 AUG 2008
  5. Manuscript Received: 14 AUG 2008

Funded by

  • Croatian Ministry of Science. Grant Numbers: 0621261-1263, 0621261-1268, 0621261-1271
  • HHMI Scholars

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Keywords:

  • Immunoevasion;
  • Murine CMV;
  • NKG2D

Abstract

NKG2D is a potent activating receptor on NK cells and a co-stimulatory receptor on CD8+ T cells. Through its ability to recognize a panel of ligands inducible by stress or infection, it plays an important role in the control of viral infections. The viruses have evolved robust mechanisms to counteract NKG2D-dependent immune response. The functions of these viral inhibitors are well characterized during the early days post-infection but less so during the chronic viral infection.

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