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Viewpoints on NK cells
Killers and beyond: NK-cell-mediated control of immune responses
Article first published online: 31 OCT 2008
DOI: 10.1002/eji.200838882
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Andoniou, C. E., Coudert, J. D. and Degli-Esposti, M. A. (2008), Killers and beyond: NK-cell-mediated control of immune responses. Eur. J. Immunol., 38: 2938–2942. doi: 10.1002/eji.200838882
Publication History
- Issue published online: 7 NOV 2008
- Article first published online: 31 OCT 2008
- Manuscript Accepted: 9 SEP 2008
- Manuscript Received: 4 SEP 2008
- Abstract
- Article
- References
- Cited By
Keywords:
- Cellular immunology;
- Cytokines;
- NK cells
Abstract
Effective immunity requires coordinated activation of innate and adaptive immune responses. NK cells are principal mediators of innate immunity, able to respond to challenge quickly and generally without prior activation. The most acknowledged functions of NK cells are their cytotoxic potential and their ability to release large amounts of cytokines, especially IFN-γ. Recently, it has become clear that NK cells are more than assassins. Indeed, NK cells play critical roles in shaping adaptive immunity.