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Highlights
A two-step model for Langerhans cell migration to skin-draining LN
Article first published online: 7 NOV 2008
DOI: 10.1002/eji.200838919
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Villablanca, E. J. and Mora, J. R. (2008), A two-step model for Langerhans cell migration to skin-draining LN. Eur. J. Immunol., 38: 2975–2980. doi: 10.1002/eji.200838919
Publication History
- Issue published online: 7 NOV 2008
- Article first published online: 7 NOV 2008
- Manuscript Accepted: 25 SEP 2008
- Manuscript Received: 19 SEP 2008
Funded by
- Crohn's & Colitis Foundation of America (CCFA)
- Cancer Research Institute (CRI)
- Center for the Study of IBD. Grant Numbers: CSIBD, DK 43351
- Massachusetts Life Sciences Center (MLSC)
- Howard M. Goodman Fellowship (MGH)
- Abstract
- Article
- References
- Cited By
Keywords:
- CCR7;
- CXCR4;
- DC;
- Langerhans cells;
- Skin
Abstract
Although the role of Langerhans cells (LC) in skin immune responses is still a matter of debate, it is known that LC require the chemokine receptor CCR7 for migrating to skin-draining LN. A report in the current issue of the European Journal of Immunology unfolds some of the intricacies of LC migration, showing that LC need CXCR4, but not CCR7, for their migration from the epidermis to the dermis. Thus, LC migration to skin-draining LN occurs in two distinct phases: a first step from the epidermis to the dermis regulated by CXCR4 and a second CCR7-dependent step from the dermis to LN. Here we discuss the potential implications of this new two-step LC migration paradigm.