Human Th17 cells: Are they different from murine Th17 cells?

Authors

  • Francesco Annunziato,

    1. Center of Excellence for Research, Transfer of Research and High Education for the Development of Novel therapies, University of Florence, Florence, Italy
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  • Lorenzo Cosmi,

    1. Center of Excellence for Research, Transfer of Research and High Education for the Development of Novel therapies, University of Florence, Florence, Italy
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  • Francesco Liotta,

    1. Center of Excellence for Research, Transfer of Research and High Education for the Development of Novel therapies, University of Florence, Florence, Italy
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  • Enrico Maggi,

    1. Center of Excellence for Research, Transfer of Research and High Education for the Development of Novel therapies, University of Florence, Florence, Italy
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  • Sergio Romagnani

    Corresponding author
    1. Center of Excellence for Research, Transfer of Research and High Education for the Development of Novel therapies, University of Florence, Florence, Italy
    • Department of Internal Medicine, University of Florence, Viale Morgagni 85, Florence 50134, Italy Fax: +39-055-412867
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Abstract

Type 17 Th (Th17) cells have been identified as a distinct population of CD4+ effector T cells different from Th1 and Th2 cells. While the pre-eminent cytokine of Th1 cells is IFN-γ and that of Th2 cells is IL-4, the distinctive cytokine of Th17 cells is IL-17A. However, although murine and human Th1 and Th2 cells exhibit strong similarities, human and murine Th17 cells seem to differ in several aspects.

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