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Keywords:

  • γδ T cells;
  • Atopy;
  • Autoimmunity;
  • IL-17;
  • Immunodeficiency;
  • Infection;
  • Inflammation

Abstract

IL-17 is produced not only by CD4+ αβ T cells, but also CD8+ αβ T cells, NKT cells, and γδ T cells, plus some non-T cells, including macrophages and neutrophils. The ability of IL-17 to deploy neutrophils to sites of inflammation imparts this cytokine with a key role in diseases of several types. Surprisingly, γδ T cells are responsible for much of the IL-17 produced in several disease models, particularly early on.