EAE: An immunologist's magic eye

Authors

  • Gurumoorthy Krishnamoorthy,

    Corresponding author
    1. Department of Neuroimmunology, Max Planck Institute of Neurobiology, Martinsried, Germany
    • Max Planck Institute of Neurobiology, Am Klopferspitz 18, D-82152 Martinsried, Germany Fax: +49-89-8578-3790
    Search for more papers by this author
  • Hartmut Wekerle

    Corresponding author
    1. Department of Neuroimmunology, Max Planck Institute of Neurobiology, Martinsried, Germany
    • Max Planck Institute of Neurobiology, Am Klopferspitz 18, D-82152 Martinsried, Germany Fax: +49-89-89950-168
    Search for more papers by this author

Abstract

EAE comes in many shapes and colors. Individual variants of EAE present a baffling complexity of different aspects and traits, clinical, immunological, and structural. But, embedded in this seemingly chaotic image, the educated eye will discern patterns that retrace fundamental features of immune response, in particular, autoimmunity and self-tolerance. EAE and its variants thus can be likened to an autostereogram, i.e. they are an immunologist's magic eye.

Ancillary