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  • 1
    Andrews, N. C., Forging a field: the golden age of iron biology. Blood 2008. 112: 219230.
  • 2
    De Domenico, I., McVey Ward, D. and Kaplan, J., Regulation of iron acquisition and storage: consequences for iron-linked disorders. Nat. Rev. Mol. Cell Biol. 2008. 9: 7281.
  • 3
    Muckenthaler, M. U., Galy, B. and Hentze, M. W., Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network. Annu. Rev. Nutr. 2008. 28: 197213.
  • 4
    Cairo, G., Bernuzzi, F. and Recalcati, S., A precious metal: iron, an essential nutrient for all cells. Genes Nutr. 2006. 1: 2539.
  • 5
    Ganz, T., Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 2003. 102: 783788.
  • 6
    Weiss, G., Iron metabolism in the anemia of chronic disease. Biochim. Biophys. Acta 2009. 1790: 682693.
  • 7
    Knutson, M. and Wessling-Resnick, M., Iron metabolism in the reticuloendothelial system. Crit. Rev. Biochem. Mol. Biol. 2003. 38: 6188.
  • 8
    Recalcati, S., Taramelli, D., Conte, D. and Cairo, G., Nitric oxide-mediated induction of ferritin synthesis in J774 macrophages by inflammatory cytokines: role of selective iron regulatory protein-2 downregulation. Blood 1998. 91: 10591066.
  • 9
    Torti, F. M. and Torti, S. V., Regulation of ferritin genes and protein. Blood 2002. 99: 35053516.
  • 10
    Nemeth, E. and Ganz, T., Regulation of iron metabolism by hepcidin. Annu. Rev. Nutr. 2006. 26: 323342.
  • 11
    Donovan, A., Lima, C. A., Pinkus, J. L., Pinkus, G. S., Zon, L. I., Robine, S. and Andrews, N. C., The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab. 2005. 1: 191200.
  • 12
    Yang, F., Liu, X. B., Quinones, M., Melby, P. C., Ghio, A. and Haile, D. J., Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation. J. Biol. Chem. 2002. 277: 3978639791.
  • 13
    Delaby, C., Pilard, N., Puy, H. and Canonne-Hergaux, F., Sequential regulation of ferroportin expression after erythrophagocytosis in murine macrophages: early mRNA induction by haem, followed by iron-dependent protein expression. Biochem. J. 2008. 411: 123131.
  • 14
    Schaer, C. A., Vallelian, F., Imhof, A., Schoedon, G. and Schaer, D. J., Heme carrier protein (HCP-1) spatially interacts with the CD163 hemoglobin uptake pathway and is a target of inflammatory macrophage activation. J. Leukoc. Biol. 2008. 83: 325333.
  • 15
    Keel, S. B., Doty, R. T., Yang, Z., Quigley, J. G., Chen, J., Knoblaugh, S., Kingsley, P. D. et al., A heme export protein is required for red blood cell differentiation and iron homeostasis. Science 2008. 319: 825828.
  • 16
    Rajagopal, A., Rao, A. U., Amigo, J., Tian, M., Upadhyay, S. K., Hall, C., Uhm, S. et al., Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins. Nature 2008. 453: 11271131.
  • 17
    Recalcati, S., Pometta, R., Levi, S., Conte, D. and Cairo, G., Response of monocyte iron regulatory protein activity to inflammation: abnormal behavior in genetic hemochromatosis. Blood 1998. 91: 25652572.
  • 18
    Kim, S. and Ponka, P., Control of transferrin receptor expression via nitric oxide-mediated modulation of iron-regulatory protein 2. J. Biol. Chem. 1999. 274: 3303533042.
  • 19
    Ludwiczek, S., Aigner, E., Theurl, I. and Weiss, G., Cytokine-mediated regulation of iron transport in human monocytic cells. Blood 2003. 101: 41484154.
  • 20
    Tacchini, L., Gammella, E., De Ponti, C., Recalcati, S. and Cairo, G., Role of HIF-1 and NF-kappaB transcription factors in the modulation of transferrin receptor by inflammatory and anti-inflammatory signals. J. Biol. Chem. 2008. 283: 2067420686.
  • 21
    Moldawer, L. L., Marano, M. A., Wei, H., Fong, Y., Silen, M. L., Kuo, G., Manogue, K. R. et al., Cachectin/tumor necrosis factor-alpha alters red blood cell kinetics and induces anemia in vivo. FASEB J. 1989. 3: 16371643.
  • 22
    Sica, A., Schioppa, T., Mantovani, A. and Allavena, P., Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy. Eur. J. Cancer 2006. 42: 717727.
  • 23
    Mosser, D. M. and Edwards, J. P., Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 2008. 8: 958969.
  • 24
    Martinez, F. O., Helming, L. and Gordon, S., Alternative activation of macrophages: an immunologic functional perspective. Annu. Rev. Immunol. 2009. 27: 451483.
  • 25
    Martinez, F. O., Gordon, S., Locati, M. and Mantovani, A., Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression. J. Immunol. 2006. 177: 73037311.
  • 26
    Ryter, S. W., Alam, J. and Choi, A. M., Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol. Rev. 2006. 86: 583650.
  • 27
    Hellman, N. E. and Gitlin, J. D., Ceruloplasmin metabolism and function. Annu. Rev. Nutr. 2002. 22: 439458.
  • 28
    Robach, P., Recalcati, S., Girelli, D., Gelfi, C., Aachmann-Andersen, N. J., Thomsen, J. J., Norgaard, A. M. et al., Alterations of systemic and muscle iron metabolism in human subjects treated with low dose recombinant erythropoietin. Blood 2009. 113: 67076715.
  • 29
    Delaby, C., Pilard, N., Goncalves, A. S., Beaumont, C. and Canonne-Hergaux, F., Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin. Blood 2005. 106: 39793984.
  • 30
    Wallander, M. L., Leibold, E. A. and Eisenstein, R. S., Molecular control of vertebrate iron homeostasis by iron regulatory proteins. Biochim. Biophys. Acta 2006. 1763: 668689.
  • 31
    Kahnert, A., Seiler, P., Stein, M., Bandermann, S., Hahnke, K., Mollenkopf, H. and Kaufmann, S. H., Alternative activation deprives macrophages of a coordinated defense program to Mycobacterium tuberculosis. Eur. J. Immunol. 2006. 36: 631647.
  • 32
    Bouton, C., Oliveira, L. and Drapier, J. C., Converse modulation of IRP1 and IRP2 by immunological stimuli in murine RAW 264.7 macrophages. J. Biol. Chem. 1998. 273: 94039408.
  • 33
    Fillebeen, C., Muckenthaler, M., Andriopoulos, B., Bisaillon, M., Mounir, Z., Hentze, M. W., Koromilas, A. E. and Pantopoulos, K., Expression of the subgenomic hepatitis C virus replicon alters iron homeostasis in Huh7 cells. J. Hepatol. 2007. 47: 1222.
  • 34
    Girelli, D., De Domenico, I., Bozzini, C., Campostrini, N., Busti, F., Castagna, A., Soriani, N. et al., Clinical, pathological, and molecular correlates in ferroportin disease: a study of two novel mutations. J. Hepatol. 2008. 49: 664671.
  • 35
    Weiss, G., Bogdan, C. and Hentze, M. W., Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13. J. Immunol. 1997. 158: 420425.
  • 36
    Ferris, C. D., Jaffrey, S. R., Sawa, A., Takahashi, M., Brady, S. D., Barrow, R. K., Tysoe, S. A. et al., Haem oxygenase-1 prevents cell death by regulating cellular iron. Nat. Cell Biol. 1999. 1: 152157.
  • 37
    Poss, K. D. and Tonegawa, S., Heme oxygenase 1 is required for mammalian iron reutilization. Proc. Natl. Acad. Sci. USA 1997. 94: 1091910924.
  • 38
    Mazumder, B., Mukhopadhyay, C. K., Prok, A., Cathcart, M. K. and Fox, P. L., Induction of ceruloplasmin synthesis by IFN-gamma in human monocytic cells. J. Immunol. 1997. 159: 19381944.
  • 39
    Peyssonnaux, C., Zinkernagel, A. S., Datta, V., Lauth, X., Johnson, R. S. and Nizet, V., TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens. Blood 2006. 107: 37273732.
  • 40
    Nguyen, N. B., Callaghan, K. D., Ghio, A. J., Haile, D. J. and Yang, F., Hepcidin expression and iron transport in alveolar macrophages. Am. J. Physiol. Lung Cell Mol. Physiol. 2006. 291: L417L425.
  • 41
    Theurl, I., Theurl, M., Seifert, M., Mair, S., Nairz, M., Rumpold, H., Zoller, H. et al., Autocrine formation of hepcidin induces iron retention in human monocytes. Blood 2008. 111: 23922399.
  • 42
    Pietrangelo, A., The ferroportin disease. Blood Cells Mol. Dis. 2004. 32: 131138.
  • 43
    Van Zandt, K. E., Sow, F. B., Florence, W. C., Zwilling, B. S., Satoskar, A. R., Schlesinger, L. S. and Lafuse, W. P., The iron export protein ferroportin 1 is differentially expressed in mouse macrophage populations and is present in the mycobacterial-containing phagosome. J. Leukoc. Biol. 2008. 84: 689700.
  • 44
    Knutson, M. D., Vafa, M. R., Haile, D. J. and Wessling-Resnick, M., Iron loading and erythrophagocytosis increase ferroportin 1 (FPN1) expression in J774 macrophages. Blood 2003. 102: 41914197.
  • 45
    Paradkar, P. N., De Domenico, I., Durchfort, N., Zohn, I., Kaplan, J. and Ward, D. M., Iron depletion limits intracellular bacterial growth in macrophages. Blood 2008. 112: 866874.
  • 46
    Nairz, M., Fritsche, G., Brunner, P., Talasz, H., Hantke, K. and Weiss, G., Interferon-gamma limits the availability of iron for intramacrophage Salmonella typhimurium. Eur. J. Immunol. 2008. 38: 19231936.
  • 47
    Chlosta, S., Fishman, D. S., Harrington, L., Johnson, E. E., Knutson, M. D., Wessling-Resnick, M. and Cherayil, B. J., The iron efflux protein ferroportin regulates the intracellular growth of Salmonella enterica. Infect. Immun. 2006. 74: 30653067.
  • 48
    Nairz, M., Theurl, I., Ludwiczek, S., Theurl, M., Mair, S. M., Fritsche, G. and Weiss, G., The co-ordinated regulation of iron homeostasis in murine macrophages limits the availability of iron for intracellular Salmonella typhimurium. Cell Microbiol. 2007. 9: 21262140.
  • 49
    Wang, L., Harrington, L., Trebicka, E., Shi, H. N., Kagan, J. C., Hong, C. C., Lin, H. Y. et al., Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice. J. Clin. Invest. 2009. 119: 33223328.
  • 50
    Wang, L., Johnson, E. E., Shi, H. N., Walker, W. A., Wessling-Resnick, M. and Cherayil, B. J., Attenuated inflammatory responses in hemochromatosis reveal a role for iron in the regulation of macrophage cytokine translation. J. Immunol. 2008. 181: 27232731.
  • 51
    Benoit, M., Desnues, B. and Mege, J. L., Macrophage polarization in bacterial infections. J. Immunol. 2008. 181: 37333739.
  • 52
    Yu, Y., Kovacevic, Z. and Richardson, D. R., Tuning cell cycle regulation with an iron key. Cell Cycle 2007. 6: 19821994.
  • 53
    Zhang, F., Wang, W., Tsuji, Y., Torti, S. V. and Torti, F. M., Post-transcriptional modulation of iron homeostasis during p53-dependent growth arrest. J. Biol. Chem. 2008. 283: 3391133918.
  • 54
    Semenza, G. L., Hypoxia-inducible factor 1 (HIF-1) pathway. Sci. STKE 2007. 2007: cm8.
  • 55
    Saeed, A. I., Sharov, V., White, J., Li, J., Liang, W., Bhagabati, N., Braisted, J. et al., TM4: a free, open-source system for microarray data management and analysis. Biotechniques 2003. 34: 374378.
  • 56
    Alberghini, A., Recalcati, S., Tacchini, L., Santambrogio, P., Campanella, A. and Cairo, G., Loss of the von Hippel Lindau tumor suppressor disrupts iron homeostasis in renal carcinoma cells. J. Biol. Chem. 2005. 280: 3012030128.