• 1
    Miller, L. H., Baruch, D. I., Marsh, K. and Doumbo, O. K., The pathogenic basis of malaria. Nature 2002. 415: 673679.
  • 2
    Schofield, L. and Grau, G. E., Immunological processes in malaria pathogenesis. Nat. Rev. Immunol. 2005. 5: 722735.
  • 3
    Potter, S., Chan-Ling, T., Ball, H. J., Mansour, H., Mitchell, A., Maluish, L. and Hunt, N. H., Perforin mediated apoptosis of cerebral microvascular endothelial cells during experimental cerebral malaria. Int. J. Parasitol. 2006. 36: 485496.
  • 4
    Combes, V., Rosenkranz, A. R., Redard, M., Pizzolato, G., Lepidi, H., Vestweber, D., Mayadas, T. N. and Grau, G. E., Pathogenic role of P-Selectin in experimental cerebral malaria: importance of the endothelial compartment. Am. J. Pathol. 2004. 164: 781786.
  • 5
    Scholl, P. F., Tripathi, A. K. and Sullivan, D. J., Bioavailable iron and heme metabolism in Plasmodium falciparum. Curr. Top. Microbiol. Immunol. 2005. 295: 293324.
  • 6
    Coban, C., Ishii, K. J., Kawai, T., Hemmi, H., Sato, S., Uematsu, S., Yamamoto, M. et al. Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin. J. Exp. Med. 2005. 201: 1925.
  • 7
    Franchi, L., Eigenbrod, T., Munoz-Planillo, R. and Nunez, G., The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat. Immunol. 2009. 10: 241247.
  • 8
    Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A. and Latz, E., Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat. Immunol. 2008. 9: 847856.
  • 9
    Bauernfeind, F. G., Horvath, G., Stutz, A., Alnemri, E. S., MacDonald, K., Speert, D., Fernandes-Alnemri, T. et al. Cutting edge: NF-kB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J. Immunol. 2009. 183: 787791.
  • 10
    Dostert, C., Guarda, G., Romero, J. F., Menu, P., Gross, O., Tardivel, A., Suva, M. L. et al. Malarial hemozoin is a Nalp3 inflammasome activating danger signal. PLoS ONE 2009. 4: e6510.
  • 11
    Tiemi Shio, M., Eisenbarth, S. C., Savaria, M., Vinet, A. F., Bellemare, M. J., Harder, K. W., Sutterwala, F. S. et al. Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases. PLoS Pathog. 2009. 5: e1000559.
  • 12
    Griffith, J. W., O'Connor, C., Bernard, K., Town, T., Goldstein, D. R. and Bucala, R., Toll-like receptor modulation of murine cerebral malaria is dependent on the genetic background of the host. J. Infect. Dis. 2007. 196: 15531564.
  • 13
    Keller, C. C., Kremsner, P. G., Hittner, J. B., Misukonis, M. A., Weinberg, J. B. and Perkins, D. J., Elevated nitric oxide production in children with malarial anemia: hemozoin-induced nitric oxide synthase type 2 transcripts and nitric oxide in blood mononuclear cells. Infect. Immun. 2004. 72: 48684873.
  • 14
    Orengo, J. M., Leliwa-Sytek, A., Evans, J. E., Evans, B., van de Hoef, D., Nyako, M., Day, K. and Rodriguez, A., Uric acid is a mediator of the Plasmodium falciparum-induced inflammatory response. PLoS ONE 2009. 4: e5194.
  • 15
    Nie, C. Q., Bernard, N. J., Norman, M. U., Amante, F. H., Lundie, R. J., Crabb, B. S., Heath, W. R. et al. IP-10-mediated T cell homing promotes cerebral inflammation over splenic immunity to malaria infection. PLoS Pathog. 2009. 5: e1000369.
  • 16
    Franchi, L. and Nunez, G., The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity. Eur. J. Immunol. 2008. 38: 20852089.
  • 17
    Aoki, S., Li, J., Itagaki, S., Okech, B. A., Egwang, T. G., Matsuoka, H., Palacpac, N. M. et al. Serine repeat antigen (SERA5) is predominantly expressed among the SERA multigene family of Plasmodium falciparum, and the acquired antibody titers correlate with serum inhibition of the parasite growth. J. Biol. Chem. 2002. 277: 4753347540.