Pyroptosis – a cell death modality of its kind?

Authors

  • Oliver Kepp,

    1. INSERM, U848, Villejuif, France
    2. 2Institut Gustave Roussy, Villejuif, France
    3. Université Paris Sud-XI, Villejuif, France
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  • Lorenzo Galluzzi,

    1. INSERM, U848, Villejuif, France
    2. 2Institut Gustave Roussy, Villejuif, France
    3. Université Paris Sud-XI, Villejuif, France
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  • Laurence Zitvogel,

    1. 2Institut Gustave Roussy, Villejuif, France
    2. Université Paris Sud-XI, Villejuif, France
    3. INSERM, U805, Villejuif, France
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  • Guido Kroemer

    Corresponding author
    1. INSERM, U848, Villejuif, France
    2. 2Institut Gustave Roussy, Villejuif, France
    3. Université Paris Sud-XI, Villejuif, France
    • INSERM, U848 Institut Gustave Roussy, Pavillon de Recherche, 1 F-94805 Villejuif (Paris), France Fax: +33-1-4211-6047
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Abstract

The term “pyroptosis” was originally introduced to describe a particular form of cell death in macrophages, which is induced by bacterial infection, is accompanied by caspase-1 activation and hence leads to the release of pyrogenic interleukins; however, it is still controversial whether pyroptosis – which can also be triggered by non-bacterial pathological stimuli – truly represents a cell death modality on its own or whether it constitutes a special case of apoptosis or necrosis.

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