- Top of page
- Morphological and biochemical features of programmed cell death
- Morphological and biochemical features of pyroptosis
- Pathophysiological relevance of pyroptosis
- Supporting Information
The term “pyroptosis” was originally introduced to describe a particular form of cell death in macrophages, which is induced by bacterial infection, is accompanied by caspase-1 activation and hence leads to the release of pyrogenic interleukins; however, it is still controversial whether pyroptosis – which can also be triggered by non-bacterial pathological stimuli – truly represents a cell death modality on its own or whether it constitutes a special case of apoptosis or necrosis.