Signaling by ROS drives inflammasome activation

Authors

  • Fabio Martinon

    Corresponding author
    1. Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
    • Department of Immunology and Infectious Diseases, Harvard School of Public Health, 651 Huntington Ave, Boston, MA 02115, USA Fax: +1-617-432-0084
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Abstract

Inflammasomes are innate immune signaling pathways that sense pathogens and injury to direct the proteolytic maturation of inflammatory cytokines such as IL-1β and IL-18. Among inflammasomes, the NLRP3/NALP3 inflammasome is the most studied. However, little is known on the molecular mechanisms that mediate its assembly and activation. Recent findings suggest that ROS are produced by NLRP3/NALP3 activators and are essential secondary messengers signaling NLRP3/NALP3 inflammasome activation.

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