- Top of page
- Alum and other particulate adjuvants activate the NLRP3 inflammasome
- Is NLRP3 required for adjuvant-induced adaptive immunity?
- Roles for inflammasomes in protective immunity: Lessons for future adjuvant design
- Concluding remarks
- Supporting Information
Adjuvants are essential for enhancing and directing immunity to vaccine antigens. Most adjuvants in clinical use are particulates, but how they drive innate and adaptive immune responses is unclear. A major recent advance was the demonstration that particulate adjuvants promote activation of the NLRP3 inflammasome. The mechanisms underlying this activation have been partly resolved and the role of NLRP3 in particulate adjuvant-induced adaptive immunity is currently the subject of intense interest.