Inflammasomes as microbial sensors

Authors

  • Luigi Franchi,

    1. University of Michigan Medical School, Department of Pathology and Comprehensive Cancer Center, Ann Arbor, MI, USA
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  • Raul Muñoz-Planillo,

    1. University of Michigan Medical School, Department of Pathology and Comprehensive Cancer Center, Ann Arbor, MI, USA
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  • Thornik Reimer,

    1. University of Michigan Medical School, Department of Pathology and Comprehensive Cancer Center, Ann Arbor, MI, USA
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  • Tatjana Eigenbrod,

    1. University of Michigan Medical School, Department of Pathology and Comprehensive Cancer Center, Ann Arbor, MI, USA
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  • Gabriel Núñez

    Corresponding author
    1. University of Michigan Medical School, Department of Pathology and Comprehensive Cancer Center, Ann Arbor, MI, USA
    • Department of Pathology, University of Michigan Medical School, 4215 CCGC, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA Fax: +1-734-647-9654
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Abstract

Members of the Nod-like receptor family and the adaptor ASC assemble into multiprotein platforms, termed inflammasomes, to mediate the activation of caspase-1 and subsequent secretion of IL-1β and IL-18. Recent studies have identified microbial and endogenous molecules as well as possible mechanisms involved in inflammasome activation.

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