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Keywords:

  • Caspase-1;
  • Inflammasome;
  • IL-1β;
  • Nlrc4;
  • Nlrp3

Abstract

Members of the Nod-like receptor family and the adaptor ASC assemble into multiprotein platforms, termed inflammasomes, to mediate the activation of caspase-1 and subsequent secretion of IL-1β and IL-18. Recent studies have identified microbial and endogenous molecules as well as possible mechanisms involved in inflammasome activation.