- Top of page
- NLR family members are critical regulators of the inflammasome
- The NLRP3 inflammasome
- The NLRP3 as a sensor of pathogens
- Mechanism of NLRP3 inflammasome activation
- Concluding remarks
- Supporting Information
Members of the Nod-like receptor family and the adaptor ASC assemble into multiprotein platforms, termed inflammasomes, to mediate the activation of caspase-1 and subsequent secretion of IL-1β and IL-18. Recent studies have identified microbial and endogenous molecules as well as possible mechanisms involved in inflammasome activation.