Does TLR2 regulate intestinal inflammation?
Article first published online: 28 DEC 2009
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
European Journal of Immunology
Volume 40, Issue 2, pages 318–320, February 2010
How to Cite
Mowat, A. M. (2010), Does TLR2 regulate intestinal inflammation?. Eur. J. Immunol., 40: 318–320. doi: 10.1002/eji.200940232
- Issue published online: 26 JAN 2010
- Article first published online: 28 DEC 2009
- Manuscript Accepted: 11 DEC 2009
- Manuscript Received: 9 DEC 2009
- Intestinal immunity;
There is almost no aspect of the immune response that is not regulated by TLR. Initially described as drivers of the innate immune response to pathogens, it is now clear that the TLR family can also influence most aspects of adaptive immunity, as well as determine how tissue cells interact with microbes in their environment. In particular, the intestine and its immune system must co-exist with an enormous community of commensal bacteria and are also on constant alert against invading pathogens. Unsurprisingly, there is therefore great interest in how TLR might regulate physiological and pathological reactions in the gut. An article in this issue of the European Journal of Immunology addresses this question with some elegant experiments that indicate that TLR2 is not essential for the pathogenesis or T-cell-mediated regulation of different models of inflammatory bowel disease in mice.