• 1
    Chan, O. T., Hannum, L. G., Haberman, A. M., Madaio, M. P. and Shlomchik, M. J., A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus. J. Exp. Med. 1999. 189: 16391648.
  • 2
    Wolf, S. D., Dittel, B. N., Hardardottir, F. and Janeway, C. A., Jr., Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice. J. Exp. Med. 1996. 184: 22712278.
  • 3
    Fillatreau, S., Sweenie, C. H., McGeachy, M. J., Gray, D. and Anderton, S. M., B cells regulate autoimmunity by provision of IL-10. Nat. Immunol. 2002. 3: 944950.
  • 4
    Mizoguchi, A., Mizoguchi, E., Takedatsu, H., Blumberg, R. S. and Bhan, A. K., Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation. Immunity 2002. 16: 219230.
  • 5
    Mauri, C., Gray, D., Mushtaq, N. and Londei, M., Prevention of arthritis by interleukin 10-producing B cells. J. Exp. Med. 2003. 197: 489501.
  • 6
    Fillatreau, S., Gray, D. and Anderton, S. M., Not always the bad guys: B cells as regulators of autoimmune pathology. Nat. Rev. Immunol. 2008. 8: 391397.
  • 7
    Mauri, C. and Ehrenstein, M. R., The “short” history of regulatory B cells. Trends Immunol. 2008. 29: 3440.
  • 8
    Mizoguchi, A. and Bhan, A. K., A case for regulatory B cells. J. Immunol. 2006. 176: 705710.
  • 9
    Yanaba, K., Bouaziz, J. D., Haas, K. M., Poe, J. C., Fujimoto, M. and Tedder, T. F., A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity 2008. 28: 639650.
  • 10
    Evans, J. G., Chavez-Rueda, K. A., Eddaoudi, A., Meyer-Bahlburg, A., Rawlings, D. J., Ehrenstein, M. R. and Mauri, C., Novel suppressive function of transitional 2 B cells in experimental arthritis. J. Immunol. 2007. 178: 78687878.
  • 11
    Duddy, M., Niino, M., Adatia, F., Hebert, S., Freedman, M., Atkins, H., Kim, H. J. and Bar-Or, A., Distinct effector cytokine profiles of memory and naive human B cell subsets and implication in multiple sclerosis. J. Immunol. 2007. 178: 60926099.
  • 12
    Blair, P. A., Norena, L. Y., Flores-Borja, F., Rawlings, D. J., Isenberg, D. A., Ehrenstein, M. R. and Mauri, C., CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients. Immunity 2010. 32: 129140.
  • 13
    Bouaziz, J. D., Calbo, S., Maho-Vaillant, M., Saussine, A., Bagot, M., Benussan, A. and Mussette, P., Human IL-10 producing regulatory B cells control CD4+ T cell proliferation. Eur. J. Immunol. 2010. 40: 26862691.
  • 14
    Barr, T. A., Brown, S., Ryan, G., Zhao, J. and Gray, D., TLR-mediated stimulation of APC: Distinct cytokine responses of B cells and dendritic cells. Eur. J. Immunol. 2007. 37: 30403053.
  • 15
    Lampropoulou, V., Hoehlig, K., Roch, T., Neves, P., Calderon Gomez, E., Sweenie, C. H., Hao, Y. et al., TLR-activated B cells suppress T cell-mediated autoimmunity. J. Immunol. 2008. 180: 47634773.
  • 16
    Buenafe, A. C. and Bourdette, D. N., Lipopolysaccharide pretreatment modulates the disease course in experimental autoimmune encephalomyelitis. J. Neuroimmunol. 2007. 182: 3240.
  • 17
    Tian, J., Zekzer, D., Hanssen, L., Lu, Y., Olcott, A. and Kaufman, D. L., Lipopolysaccharide-activated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice. J. Immunol. 2001. 167: 10811089.
  • 18
    Matsushita, T., Yanaba, K., Bouaziz, J. D., Fujimoto, M. and Tedder, T. F., Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. J. Clin. Invest. 2008. 118: 34203430.
  • 19
    Gray, M., Miles, K., Salter, D., Gray, D. and Savill, J., Apoptotic cells protect mice from autoimmune inflammation by the induction of regulatory B cells. Proc. Natl. Acad. Sci. USA 2007. 104: 1408014085.
  • 20
    Eckl-Dorna, J. and Batista, F. D., BCR-mediated uptake of antigen linked to TLR9 ligand stimulates B-cell proliferation and antigen-specific plasma cell formation. Blood 2009. 113: 39693977.
  • 21
    Barr, T. A., Brown, S., Mastroeni, P. and Gray, D., TLR and B cell receptor signals to B cells differentially program primary and memory Th1 responses to Salmonella enterica. J. Immunol. 2010 185: 27832789.
  • 22
    Wojciechowski, W., Harris, D. P., Sprague, F., Mousseau, B., Makris, M., Kusser, K., Honjo, T. et al., Cytokine-producing effector B cells regulate type 2 immunity to H. polygyrus. Immunity 2009. 30: 421433.