• 1
    Eyrich, M., Wollny, G., Tzaribaschev, N., Dietz, K., Brugger, D., Bader, P., Lang, P. et al., Onset of thymic recovery and plateau of thymic output are differentially regulated after stem cell transplantation in children. Biol. Blood Marrow Transplant. 2005. 11: 194205.
  • 2
    Hozumi, K., Mailhos, C., Negishi, N., Hirano, K., Yahata, T., Ando, K., Zuklys, S. et al., Delta-like 4 is indispensable in thymic environment specific for T cell development. J. Exp. Med. 2008. 205: 25072513.
  • 3
    Schmitt, T. M. and Zuniga-Pflucker, J. C., Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity 2002. 17: 749756.
  • 4
    Haddad, R., Guardiola, P., Izac, B., Thibault, C., Radich, J., Delezoide, A. L., Baillou, C. et al., Molecular characterization of early human T/NK and B-lymphoid progenitor cells in umbilical cord blood. Blood 2004. 104: 39183926.
  • 5
    Six, E. M., Bonhomme, D., Monteiro, M., Beldjord, K., Jurkowska, M., Cordier-Garcia, C., Garrigue, A. et al., A human postnatal lymphoid progenitor capable of circulating and seeding the thymus. J. Exp. Med. 2007. 204: 30853093.
  • 6
    Awong, G., Herer, E., Surh, C. D., Dick, J. E., La Motte-Mohs, R. N. and Zuniga-Pflucker, J. C., Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells. Blood 2009. 114: 972982.
  • 7
    Meek, B., Cloosen, S., Borsotti, C., Van Elssen, C. H., Vanderlocht, J., Schnijderberg, M. C., van der Poel, M. W. et al., In vitro differentiated T/NK cell progenitors derived from human CD34+ cells mature in the thymus. Blood 2010. 115: 261264.
  • 8
    Van Coppernolle, S., Verstichel, G., Timmermans, F., Velghe, I., Vermijlen, D., De Smedt, M., Leclercq, G. et al., Functionally mature CD4 and CD8 TCRalphabeta cells are generated in OP9-DL1 cultures from human CD34+ hematopoietic cells. J. Immunol. 2009. 183: 48594870.
  • 9
    Shultz, L. D., Lyons, B. L., Burzenski, L. M., Gott, B., Chen, X., Chaleff, S., Kotb, M. et al., Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J. Immunol. 2005. 174: 64776489.
  • 10
    Kawamoto, H. and Katsura, Y., A new paradigm for hematopoietic cell lineages: revision of the classical concept of the myeloid-lymphoid dichotomy. Trends Immunol. 2009. 30: 193200.
  • 11
    De Smedt, M., Leclercq, G., Vandekerckhove, B., Kerre, T., Taghon, T. and Plum, J., T-lymphoid differentiation potential measured in vitro is higher in CD34+CD38-/lo hematopoietic stem cells from umbilical cord blood than from bone marrow and is an intrinsic property of the cells. Haematologica 2011. 96: 646654.
  • 12
    Clark, R. A., Yamanaka, K., Bai, M., Dowgiert, R. and Kupper, T. S., Human skin cells support thymus-independent T cell development. J. Clin. Invest. 2005. 115: 32393249.
  • 13
    Poznansky, M. C., Evans, R. H., Foxall, R. B., Olszak, I. T., Piascik, A. H., Hartman, K. E., Brander, C. et al., Efficient generation of human T cells from a tissue-engineered thymic organoid. Nat. Biotechnol. 2000. 18: 729734.
  • 14
    Upton, T., Bechtel, D., Huynh, V. and Rosenzweig, M., De novo synthesis of T cells from mPB CD34+ cells cultured in a 3-D-dimensional thymic organoid. Blood 2003. 102: 279a.