• 1
    Palomares, O., Yaman, G., Azkur, A. K., Akkoc, T., Akdis, M. and Akdis, C. A., Role of Treg in immune regulation of allergic diseases. Eur. J. Immunol. 2010. 40: 12321240.
  • 2
    Akdis, M., Burgler, S., Crameri, R., Eiwegger, T., Fujita, H., Gomez, E., Klunker, S. et al., Interleukins, from 1 to 37, and interferon-gamma: receptors, functions, and roles in diseases. J. Allergy Clin. Immunol. 2011. 127: 701721 e70.
  • 3
    Meiler, F., Zumkehr, J., Klunker, S., Ruckert, B., Akdis, C. A. and Akdis, M., In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure. J. Exp. Med. 2008. 205: 28872898.
  • 4
    Klunker, S., Chong, M. M., Mantel, P. Y., Palomares, O., Bassin, C., Ziegler, M., Ruckert, B. et al., Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells. J. Exp. Med. 2009. 206: 27012715.
  • 5
    Schmitz, J., Owyang, A., Oldham, E., Song, Y., Murphy, E., McClanahan, T. K., Zurawski, G. et al., IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 2005. 23: 479490.
  • 6
    Dillon, S. R., Sprecher, C., Hammond, A., Bilsborough, J., Rosenfeld-Franklin, M., Presnell, S. R., Haugen, H. S. et al., Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Nat. Immunol. 2004. 5: 752760.
  • 7
    Neill, D. R., Wong, S. H., Bellosi, A., Flynn, R. J., Daly, M., Langford, T. K., Bucks, C. et al., Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature 2010. 464: 13671370.
  • 8
    Meyer, N., Zimmermann, M., Bürgler, S., Bassin, C., Woehrl, S., Moritz, K., Rhyner, C. et al., IL-32 is expressed by human primary keratinocytes and modulates keratinocyte apoptosis in atopic dermatitis. J. Allergy Clin. Immunol. 2010. 125: 858865. e10.
  • 9
    Zimmermann, M., Koreck, A., Meyer, N., Basinski, T., Meiler, F., Simone, B., Woehrl, S. et al., TNF-like weak inducer of apoptosis (TWEAK) and TNF-alpha cooperate in the induction of keratinocyte apoptosis. J. Allergy Clin. Immunol. 2011. 127: 200207, 207 e1–10.
  • 10
    Chackerian, A. A., Oldham, E. R., Murphy, E. E., Schmitz, J., Pflanz, S. and Kastelein, R. A., IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex. J. Immunol. 2007. 179: 25512555.
  • 11
    Saenz, S. A., Noti, M. and Artis, D., Innate immune cell populations function as initiators and effectors in Th2 cytokine responses. Trends Immunol. 2010. 31: 407413.
  • 12
    Allakhverdi, Z., Comeau, M. R., Smith, D. E., Toy, D., Endam, L. M., Desrosiers, M., Liu, Y. J. et al., CD34+ hemopoietic progenitor cells are potent effectors of allergic inflammation. J. Allergy Clin. Immunol. 2009. 123: 472478.
  • 13
    Besnard, A. G., Togbe, D., Guillou, N., Erard, F., Quesniaux, V. and Ryffel, B., IL-33-activated dendritic cells are critical for allergic airway inflammation. Eur. J. Immunol. 2011. 41: 16751686.
  • 14
    Alves-Filho, J. C., Sonego, F., Souto, F. O., Freitas, A., Verri, W. A., Jr., Auxiliadora-Martins, M., Basile-Filho, A. et al., Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection. Nat. Med. 2010. 16: 708712.
  • 15
    Strickland, D. H., Stumbles, P. A., Zosky, G. R., Subrata, L. S., Thomas, J. A., Turner, D. J., Sly, P. D. and Holt, P. G., Reversal of airway hyperresponsiveness by induction of airway mucosal CD4+CD25+regulatory T cells. J. Exp. Med. 2006. 203: 26492660.
  • 16
    Xu, D., Chan, W. L., Leung, B. P., Huang, F., Wheeler, R., Piedrafita, D., Robinson, J. H. and Liew, F. Y., Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells. J. Exp. Med. 1998. 187: 787794.
  • 17
    Hayakawa, H., Hayakawa, M., Kume, A. and Tominaga, S., Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation. J. Biol. Chem. 2007. 282: 2636926380.
  • 18
    Luthi, A. U., Cullen, S. P., McNeela, E. A., Duriez, P. J., Afonina, I. S., Sheridan, C., Brumatti, G. et al., Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases. Immunity 2009. 31: 8498.
  • 19
    Kurowska-Stolarska, M., Stolarski, B., Kewin, P., Murphy, G., Corrigan, C. J., Ying, S., Pitman, N. et al., IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation. J. Immunol. 2009. 183: 64696477.
  • 20
    Prefontaine, D., Lajoie-Kadoch, S., Foley, S., Audusseau, S., Olivenstein, R., Halayko, A. J., Lemiere, C. et al., Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells. J. Immunol. 2009. 183: 50945103.
  • 21
    Moffatt, M. F., Gut, I. G., Demenais, F., Strachan, D. P., Bouzigon, E., Heath, S., von Mutius, E. et al., A large-scale, consortium-based genomewide association study of asthma. N. Engl. J. Med. 2010. 363: 12111221.