Macrophage Viewpoints

You have full text access to this OnlineOpen article

F4/80 and the related adhesion-GPCRs

  1. Siamon Gordon1,*,
  2. Jörg Hamann2,
  3. Hsi-Hsien Lin3,
  4. Martin Stacey4

Article first published online: 26 AUG 2011

DOI: 10.1002/eji.201141715

Issue

European Journal of Immunology

European Journal of Immunology

Volume 41, Issue 9, pages 2472–2476, September 2011

Additional Information

How to Cite

Gordon, S., Hamann, J., Lin, H.-H. and Stacey, M. (2011), F4/80 and the related adhesion-GPCRs. Eur. J. Immunol., 41: 2472–2476. doi: 10.1002/eji.201141715

Author Information

  1. 1

    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK

  2. 2

    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

  3. 3

    Department of Microbiology and Immunology, Chang Gung University, Tao-Yuan, Taiwan

  4. 4

    Institute of Molecular and Cellular Biology, University of Leeds, Leeds, UK

*Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK Fax: +44-1865-275515

Publication History

  1. Issue published online: 26 AUG 2011
  2. Article first published online: 26 AUG 2011

Funded by

  • National Science Council, Taiwan. Grant Number: NSC-98-2320-B-182-028

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (484K)

Keywords:

  • Adhesion-GPCRs;
  • EGF-TM7 family;
  • Macrophages

Abstract

The F4/80 monoclonal antibody was first reported in this journal 30 years ago (Eur. J. Immunol. 1981. 11: 805–815). F4/80 has become a widely used marker for monocytes and many, but not all, tissue macrophages in the mouse. F4/80 is a member of the EGF-TM7 family of leukocyte plasma membrane heptahelical molecules, which includes CD97 and EMR2. This Viewpoint summarises current knowledge of the expression, structure and functions of the EGF-TM7 family, as part of a larger family of tissue adhesion-GPCRs.

View Full Article with Supporting Information (HTML) Get PDF (484K)