IL-15 inhibits IL-7Rα expression by memory-phenotype CD8+ T cells in the bone marrow
Article first published online: 26 APR 2012
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
European Journal of Immunology
Volume 42, Issue 5, pages 1129–1139, May 2012
How to Cite
Quinci, A. C., Vitale, S., Parretta, E., Soriani, A., Iannitto, M. L., Cippitelli, M., Fionda, C., Bulfone-Paus, S., Santoni, A. and Di Rosa, F. (2012), IL-15 inhibits IL-7Rα expression by memory-phenotype CD8+ T cells in the bone marrow. Eur. J. Immunol., 42: 1129–1139. doi: 10.1002/eji.201142019
- Issue published online: 26 APR 2012
- Article first published online: 26 APR 2012
- Manuscript Accepted: 5 JAN 2012
- Manuscript Revised: 6 DEC 2011
- Manuscript Received: 10 AUG 2011
- Italian MIUR (Ministero dell'Istruzione, Università e Ricerca). Grant Number: PRIN 20077EYEXN_002
Disclaimer: Supplementary materials have been peer-reviewed but not copyedited.
Figure S1. Both CD122high and CD122int/low CD44high CD8+ T cells from WT mice have reduced CD127 membrane expression in BM.
Figure S2. Adoptive transfer of WT CD44high CD8+ T cells into WT hosts: representative flow cytometric analysis.
Figure S3. Lack of downmodulation of membrane CD127 by CD127tg CD44high CD8+ T cells after overnight stimulation with IL-15.
Figure S4. CD127 membrane expression by CD44high CD8+ T cells from CD127tg and WT mice.
Table S1. Cell numbers, CD8+ T cell and CD44high cell percentages in spleen, LNs, and BM of CD127tg and WT mice.
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