SEARCH

SEARCH BY CITATION

References

  • 1
    Wullschleger, S., Loewith, R.andHall, M. N., TOR signaling in growth and metabolism. Cell 2006. 124: 471.
  • 2
    Mondino, A. and Mueller, D. L., mTOR at the crossroads of T cell proliferation and tolerance. Semin Immunol. 2007. 19: 162172.
  • 3
    Kuo, C. J., Chung, J., Fiorentino, D. F., Flanagan, W. M., Blenis, J.andCrabtree, G. R., Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature 1992. 358: 7073.
  • 4
    Battaglia, M., Stabilini, A.andRoncarolo, M. G., Rapamycin selectively expands CD4+ CD25+ FoxP3+ regulatory T cells. Blood 2005. 105: 47434748.
  • 5
    Araki, K., Turner, A. P., Shaffer, V. O., Gangappa, S., Keller, S. A., Bachmann, M. F., Larsen, C. P.et al.,mTOR regulates memory CD8 T-cell differentiation. Nature 2009. 460: 108112.
  • 6
    Jacinto, E., Facchinetti, V., Liu, D., Soto, N., Wei, S., Jung, S. Y., Huang, Q.et al., SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 2006. 127: 125137.
  • 7
    Sarbassov, D. D., Guertin, D. A., Ali, S. M.andSabatini, D. M., Phosphorylation and regulation of Akt/PKB by the Rictor-mTOR complex. Science 2005. 307: 10981101.
  • 8
    Facchinetti, V., Ouyang, W., Wei, H., Soto, N., Lazorchak, A., Gould, C., Lowry, C.et al.,The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J. 2008. 27: 19321943.
  • 9
    Peterson, T. R., Sengupta, S. S., Harris, T. E., Carmack, A. E., Kang, S. A., Balderas, E., Guertin, D. A. et al., mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell 146: 408420.
  • 10
    Delgoffe, G. M., Kole, T. P., Zheng, Y., Zarek, P. E., Matthews, K. L., Xiao, B., Worley, P. F.et al.,The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity 2009. 30: 832844.
  • 11
    Delgoffe, G. M., Pollizzi, K. N., Waickman, A. T., Heikamp, E., Meyers, D. J., Horton, M. R., Xiao, B.et al.,The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat. Immunol. 2011. 12: 295303.
  • 12
    Lee, K., Gudapati, P., Dragovic, S., Spencer, C., Joyce, S., Killeen, N., Magnuson, M. A.et al.,Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity 2010. 32: 743753.
  • 13
    Lazorchak, A. S., Liu, D., Facchinetti, V., Di Lorenzo, A., Sessa, W. C., Schatz, D. G.andSu, B., Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells. Mol. Cell 2010. 39: 433443.
  • 14
    Holmes, R.andZuniga-Pflucker, J. C., The OP9-DL1 system: generation of T-lymphocytes from embryonic or hematopoietic stem cells in vitro. Cold Spring Harb. Protoc. 2009. 2009: pdb prot5156.
  • 15
    Ouyang, W., Beckett, O., Ma, Q., Paik, J. H., DePinho, R. A.andLi, M. O., Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells. Nat. Immunol. 2010. 11: 618627.
  • 16
    Kerdiles, Y. M., Beisner, D. R., Tinoco, R., Dejean, A. S., Castrillon, D. H., DePinho, R. A.andHedrick, S. M., Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nat. Immunol. 2009. 10: 176184.
  • 17
    Sauer, S., Bruno, L., Hertweck, A., Finlay, D., Leleu, M., Spivakov, M., Knight, Z. A. et al., T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proc. Natl. Acad. Sci. USA 2008. 105: 77977802.
  • 18
    Juntilla, M. M., Wofford, J. A., Birnbaum, M. J., Rathmell, J. C.andKoretzky, G. A., Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation. Proc. Natl. Acad. Sci. USA 2007. 104: 1210512110.
  • 19
    Feldman, M. E., Apsel, B., Uotila, A., Loewith, R., Knight, Z. A., Ruggero, D.andShokat, K. M., Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol. 2009. 7: e38.
  • 20
    Juntilla, M. M., Wofford, J. A., Birnbaum, M. J., Rathmell, J. C.andKoretzky, G. A., Akt1 and Akt2 are required for alpha beta thymocyte survival and differentiation. Proc. Natl. Acad. Sci. USA 2007. 104: 1210512110.
  • 21
    Delgoffe, G. M., Pollizzi, K. N., Waickman, A. T., Heikamp, E., Meyers, D. J., Horton, M. R., Xiao, B.et al.,The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat. Immunol. 2011. 12: 295303.
  • 22
    Ouyang, W., Beckett, O., Flavell, R. A.andLi, M. O., An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance. Immunity 2009. 30: 358371.
  • 23
    Brunet, A., Park, J., Tran, H., Hu, L. S., Hemmings, B. A.andGreenberg, M. E., Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol. Cell Biol. 2001. 21: 952965.
  • 24
    Garcia-Martinez, J. M.andAlessi, D. R., mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). Biochem. J. 2008. 416: 375385.
  • 25
    Hong, F., Larrea, M. D., Doughty, C., Kwiatkowski, D. J., Squillace, R.andSlingerland, J. M., mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation. Mol. Cell 2008. 30: 701711.
  • 26
    Cheng, J., Zhang, D., Kim, K., Zhao, Y.andSu, B., Mip1, an MEKK2-interacting protein, controls MEKK2 dimerization and activation. Mol. Cell Biol. 2005. 25: 59555964.
  • 27
    Chang, X., Liu, D., Wang, X., Lin, A., Zhao, H.andSu, B., The kinases MEKK2 and MEKK3 regulate transforming growth factor-[beta]-mediated helper T cell differentiation. Immunity 2011. 34: 201212.
  • 28
    Wang, X., Zhang, F., Chen, F., Liu, D., Zheng, Y., Zhang, Y., Dong, C.et al.,MEKK3 regulates IFN-gamma production in T cells through the Rac1/2-dependent MAPK cascades. J. Immunol. 2011. 186: 57915800.
  • 29
    Wang, X., Chang, X., Facchinetti, V., Zhuang, Y.andSu, B., MEKK3 is essential for lymphopenia-induced T cell proliferation and survival. J. Immunol. 2009. 182: 35973608.