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Apoptotic tumor cells induce IL-27 release from human DCs to activate Treg cells that express CD69 and attenuate cytotoxicity

  1. Divya Sekar1,
  2. Christina Hahn1,
  3. Bernhard Brüne1,
  4. Edward Roberts2,
  5. Andreas Weigert1,*

Article first published online: 8 JUN 2012

DOI: 10.1002/eji.201142093

Issue

European Journal of Immunology

European Journal of Immunology

Volume 42, Issue 6, pages 1585–1598, June 2012

Additional Information

How to Cite

Sekar, D., Hahn, C., Brüne, B., Roberts, E. and Weigert, A. (2012), Apoptotic tumor cells induce IL-27 release from human DCs to activate Treg cells that express CD69 and attenuate cytotoxicity. Eur. J. Immunol., 42: 1585–1598. doi: 10.1002/eji.201142093

Author Information

  1. 1

    Institute of Biochemistry I/ZAFES, Goethe-University Frankfurt, Frankfurt, Germany

  2. 2

    Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA

*Full correspondence Dr. Andreas Weigert, Goethe-University Frankfurt, Institute of Biochemistry I – Pathobiochemistry/ZAFES, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany
Fax: +49-69-6301 4203
e-mail: weigert@zbc.kgu.de

Publication History

  1. Issue published online: 8 JUN 2012
  2. Article first published online: 8 JUN 2012
  3. Manuscript Accepted: 3 FEB 2012
  4. Manuscript Revised: 21 DEC 2011
  5. Manuscript Received: 8 SEP 2011

Funded by

  • Medical Faculty, Goethe-University Frankfurt
  • Sander Foundation. Grant Number: 2007.070.2
  • DFG. Grant Numbers: Br999, ECCPS
  • National Institute of Health Molecular Library Screen Center. Grant Number: U54 MH084512A

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Disclaimer: Supplementary materials have been peer-reviewed but not copyedited.

FilenameFormatSizeDescription
eji2261-sup-0001-s1.pdf755KSupporting Information Figure 1.DC phenotype upon activation with tumor-cell supernatants.
eji2261-sup-0001-s1.pdf755KSupporting Information Figure 2. Phenotype of IL-2-expanded lymphocytes.
eji2261-sup-0001-s1.pdf755KSupporting Information Figure 3.CD39/CD69 expression by non-Treg.
eji2261-sup-0001-s1.pdf755KSupporting Information Figure 4. Purity of isolated CD4+CD25+Treg.
eji2261-sup-0001-s1.pdf755KSupporting Information Figure 5. Effect of IDO inhibition on ACM-induced suppression of cytotoxicity.
eji2261-sup-0001-s1.pdf755KSupporting Information Figure 6. Cytokine production by T cells in DC cocultures.
eji2261-sup-0001-s1.pdf755KSupporting Information Figure 7. Enrichment of CD39/CD69-expressing Treg in the CD4+CD8+ doublet population.

Please note: Wiley-Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

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