IL-21 promotes the production of anti-DNA IgG but is dispensable for kidney damage in lyn−/− mice
Version of Record online: 18 DEC 2012
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
European Journal of Immunology
Volume 43, Issue 2, pages 382–393, February 2013
How to Cite
Gutierrez, T., Mayeux, J. M., Ortega, S. B., Karandikar, N. J., Li, Q.-Z., Rakheja, D., Zhou, X. J. and Satterthwaite, A. B. (2013), IL-21 promotes the production of anti-DNA IgG but is dispensable for kidney damage in lyn−/− mice. Eur. J. Immunol., 43: 382–393. doi: 10.1002/eji.201142095
- Issue online: 14 FEB 2013
- Version of Record online: 18 DEC 2012
- Accepted manuscript online: 21 NOV 2012 03:08AM EST
- Manuscript Accepted: 15 NOV 2012
- Manuscript Revised: 27 OCT 2012
- Manuscript Received: 9 SEP 2011
- NIH. Grant Numbers: P01 AI039824, 1 F31 GM076982, P50 AR055503, K24AI079272
As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Figure S1. The majority of IL-21 in lyn-/- spleens is expressed by CD4+ T cells.
Figure S2. IL-21-deficiency does not affect total Ig levels in lyn-/- mice.
Figure S3. Expression of PD-1 and PSGL-1 on lyn-/- and lyn-/-IL-21-/- T cells.
Figure S4. Representative FACS plots of T cells from aged mice.
Figure S5. Variability in total splenocyte numbers in aged lyn-/- mice.
Figure S6. Analyisis of kidney damage and inflammation in lyn-/-IL-21-/- mice.
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.