• 1
    Sharpe, A. H., Mechanisms of costimulation. Immunol. Rev. 2009. 229: 511.
  • 2
    Nocentini, G. and Riccardi, C., GITR: a modulator of immune response and inflammation. Adv. Exp. Med. Biol. 2009. 647: 156173.
  • 3
    McHugh, R. S., Whitters, M. J., Piccirillo, C. A., Young, D. A., Shevach, E. M., Collins, M. and Byrne, M. C., CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 2002. 16: 311323.
  • 4
    Ronchetti, S., Zollo, O., Bruscoli, S., Agostini, M., Bianchini, R., Nocentini, G., Ayroldi, E. et al., GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations. Eur. J. Immunol. 2004. 34: 613622.
  • 5
    Stephens, G. L., McHugh, R. S., Whitters, M. J., Young, D. A., Luxenberg, D., Carreno, B. M., Collins, M. et al., Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells. J. Immunol. 2004. 173: 50085020.
  • 6
    Vecchiarelli, A., Pericolini, E., Gabrielli, E., Agostini, M., Bistoni, F., Nocentini, G., Cenci, E. et al., The GITRL-GITR system alters TLR-4 expression on DC during fungal infection. Cell Immunol. 2009. 257: 1322.
  • 7
    Nocentini, G., Cuzzocrea, S., Bianchini, R., Mazzon, E. and Riccardi, C., Modulation of acute and chronic inflammation of the lung by GITR and its ligand. Ann. NY Acad. Sci. 2007. 1107: 380391.
  • 8
    Hu, P., Arias, R. S., Sadun, R. E., Nien, Y. C., Zhang, N., Sabzevari, H., Lutsiak, M. E. et al., Construction and preclinical characterization of Fc-mGITRL for the immunotherapy of cancer. Clin. Cancer. Res. 2008. 14: 579588.
  • 9
    Ponte, J. F., Ponath, P., Gulati, R., Slavonic, M., Paglia, M., O'Shea, A., Tone, M. et al., Enhancement of humoral and cellular immunity with an anti-glucocorticoid-induced tumor necrosis factor receptor monoclonal antibody. Immunology 2010. 130: 231242.
  • 10
    Ramirez-Montagut, T., Chow, A., Hirschhorn-Cymerman, D., Terwey, T. H., Kochman, A. A., Lu, S., Miles, R. C. et al., Glucocorticoid-induced TNF receptor family related gene activation overcomes tolerance/ignorance to melanoma differentiation antigens and enhances antitumor immunity. J. Immunol. 2006. 176: 64346442.
  • 11
    van Olffen, R. W., Koning, N., van Gisbergen, K. P., Wensveen, F. M., Hoek, R. M., Boon, L., Hamann, J. et al., GITR triggering induces expansion of both effector and regulatory CD4+ T cells in vivo. J. Immunol. 2009. 182: 74907500.
  • 12
    Okayasu, I., Hatakeyama, S., Yamada, M., Ohkusa, T., Inagaki, Y. and Nakaya, R., A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 1990. 98: 694702.
  • 13
    Saraiva, M. and O’Garra, A., The regulation of IL-10 production by immune cells. Nat. Rev. Immunol. 2010. 10: 170181.
  • 14
    Couper, K. N., Blount, D. G., Wilson, M. S., Hafalla, J. C., Belkaid, Y., Kamanaka, M., Flavell, R. A. et al., IL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection. PLoS Pathog. 2008. 4: e1000004.
  • 15
    Awasthi, A., Carrier, Y., Peron, J. P., Bettelli, E., Kamanaka, M., Flavell, R. A., Kuchroo, V. K. et al., A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat. Immunol. 2007. 8: 13801389.
  • 16
    Apetoh, L., Quintana, F. J., Pot, C., Joller, N., Xiao, S., Kumar, D., Burns, E. J. et al., The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27. Nat. Immunol. 2010. 11: 854861.
  • 17
    Gandhi, R., Kumar, D., Burns, E. J., Nadeau, M., Dake, B., Laroni, A., Kozoriz, D. et al., Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells. Nat. Immunol. 2010. 11: 846853.
  • 18
    Bauquet, A. T., Jin, H., Paterson, A. M., Mitsdoerffer, M., Ho, I. C., Sharpe, A. H. and Kuchroo, V. K., The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat. Immunol. 2009. 10: 167175.
  • 19
    Shimizu, J., Yamazaki, S., Takahashi, T., Ishida, Y. and Sakaguchi, S., Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol. 2002. 3: 135142.
  • 20
    Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M., Fehervari, Z., Nomura, T. et al., CTLA-4 control over Foxp3+ regulatory T cell function. Science 2008. 322: 271275.
  • 21
    Clough, L. E., Wang, C. J., Schmidt, E. M., Booth, G., Hou, T. Z., Ryan, G. A. and Walker, L. S., Release from regulatory T cell-mediated suppression during the onset of tissue-specific autoimmunity is associated with elevated IL-21. J. Immunol. 2008. 180: 53935401.
  • 22
    Moore, K. W., de Waal Malefyt, R., Coffman, R. L. and O'Garra, A., Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 2001. 19: 683765.
  • 23
    Zheng, Y., Josefowicz, S., Chaudhry, A., Peng, X. P., Forbush, K. and Rudensky, A. Y., Role of conserved non-coding DNAelements in the Foxp3 gene in regulatory T-cell fate. Nature 2010. 463: 808812.
  • 24
    Molle, C., Goldman, M. and Goriely, S., Critical role of the IFN-stimulated gene factor 3 complex in TLR-mediated IL-27p28 gene expression revealing a two-step activation process. J. Immunol. 2010. 184: 17841792.
  • 25
    Grohmann, U., Volpi, C., Fallarino, F., Bozza, S., Bianchi, R., Vacca, C., Orabona, C. et al., Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy. Nat. Med. 2007. 13: 579586.
  • 26
    Sun, J., Madan, R., Karp, C. L. and Braciale, T. J., Effector T cells control lung inflammation during acute influenza virus infection by producingIL-10. Nat. Med. 2009. 15: 277284.