Regulating inflammation: ADAM8 – a new player in the game

Authors

  • Alexander Zarbock,

    Corresponding author
    1. Department of Anesthesiology and Critical Care Medicine, University of Münster, Münster, Germany
    2. Max-Planck Institute for Molecular Biomedicine, Münster, Germany
    • Department of Anesthesiology and Critical Care Medicine, University of Münster, Albert-Schweitzer-Campus 1, Building A1, 48149, Münster, Germany Fax: +49-251-88704
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  • Jan Rossaint

    1. Department of Anesthesiology and Critical Care Medicine, University of Münster, Münster, Germany
    2. Max-Planck Institute for Molecular Biomedicine, Münster, Germany
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Abstract

Leukocyte recruitment to sites of inflammation proceeds in a cascade-like fashion. However, it is less clear how the complex interactions among the different adhesion molecules involved in this process are coordinately regulated. A report in this issue of the European Journal of Immunology [Eur. J. Immunol. 2011. 41: 3436–3442] shows that ADAM8 may participate in the control of the adhesion molecule P-selectin glycoprotein ligand 1. This finding suggests a new role for ADAM8 in the regulation of inflammatory processes.

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