Leukocyte recruitment to sites of inflammation proceeds in a cascade-like fashion. However, it is less clear how the complex interactions among the different adhesion molecules involved in this process are coordinately regulated. A report in this issue of the European Journal of Immunology [Eur. J. Immunol. 2011. 41: 3436–3442] shows that ADAM8 may participate in the control of the adhesion molecule P-selectin glycoprotein ligand 1. This finding suggests a new role for ADAM8 in the regulation of inflammatory processes.