From crucial to negligible: Functional CD8+ T-cell responses and their dependence on CD4+ T-cell help

Authors

  • Melanie Wiesel,

    Corresponding author
    1. Institute for Microbiology, Zürich, Switzerland
    • CorrespondenceProf. Annette Oxenius, Institute for Microbiology, ETH Zürich, Wolfgang-Pauli-Str. 10, 8093 Zürich, Switzerland

      Fax: +41-44-632-10-98

      e-mail: oxenius@micro.biol.ethz.ch

      Current address: Melanie Wiesel, Novartis Institutes for Biomedical Research, Basel, Switzerland

    Search for more papers by this author
  • and Annette Oxenius

    Corresponding author
    1. Institute for Microbiology, Zürich, Switzerland
    • CorrespondenceProf. Annette Oxenius, Institute for Microbiology, ETH Zürich, Wolfgang-Pauli-Str. 10, 8093 Zürich, Switzerland

      Fax: +41-44-632-10-98

      e-mail: oxenius@micro.biol.ethz.ch

      Current address: Melanie Wiesel, Novartis Institutes for Biomedical Research, Basel, Switzerland

    Search for more papers by this author

Abstract

CD8+ T cells play an important role in controlling pathogenic infections and are therefore key players in the immune response. It has been shown that among other factors CD4+ T cells can shape the magnitude as well as the quality of primary and/or secondary CD8+ T-cell responses. However, due to the complexity and the differences among diverse immunization or infection models, the overall requirement, the time points, as well as the specific mechanism(s) of CD4+ T-cell help may differ substantially. Here, we summarize current knowledge about the differential requirement of CD4+ T-cell help in promoting primary CD8+ T-cell responses as well as establishing functional memory CD8+ T cells in various experimental settings.

Ancillary