- Top of page
- CD8+ T-cell responses
- Primary CD8+ T-cell responses — do they require T-cell help?
- What renders certain infections T-cell help dependent?
- Functional memory CD8+ T cells in the absence of T-cell help?
- Programming versus maintenance — what is the timing of T-cell help?
- IL-2 – the key factor of T-cell help?
- Chronic viral infections — T-cell help is appreciated
- Concluding remarks
CD8+ T cells play an important role in controlling pathogenic infections and are therefore key players in the immune response. It has been shown that among other factors CD4+ T cells can shape the magnitude as well as the quality of primary and/or secondary CD8+ T-cell responses. However, due to the complexity and the differences among diverse immunization or infection models, the overall requirement, the time points, as well as the specific mechanism(s) of CD4+ T-cell help may differ substantially. Here, we summarize current knowledge about the differential requirement of CD4+ T-cell help in promoting primary CD8+ T-cell responses as well as establishing functional memory CD8+ T cells in various experimental settings.