Lack of T cells in Act1-deficient mice results in elevated IgM-specific autoantibodies but reduced lupus-like disease
Version of Record online: 17 JUL 2012
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
European Journal of Immunology
Volume 42, Issue 7, pages 1695–1705, July 2012
How to Cite
Johnson, A. C., Davison, L. M., Giltiay, N. V., Vareechon, C., Li, X. and Jørgensen, T. N. (2012), Lack of T cells in Act1-deficient mice results in elevated IgM-specific autoantibodies but reduced lupus-like disease. Eur. J. Immunol., 42: 1695–1705. doi: 10.1002/eji.201142238
- Issue online: 17 JUL 2012
- Version of Record online: 17 JUL 2012
- Accepted manuscript online: 14 MAY 2012 07:40AM EST
- Manuscript Accepted: 19 APR 2012
- Manuscript Revised: 31 JAN 2012
- Manuscript Received: 10 NOV 2011
Disclaimer: Supplementary materials have been peer-reviewed but not copyedited.
Figure 1. IgA deposition is decreased in T-cell deficient mice.
Figure 2. Representative H&E stainings of submaxillary glands isolated from 8-week old or 12-month-old WT and B6.Act1−/−mice show increased infiltration of mononuclear cells in both.
Figure 3. Percentages of plasma cells (CD138+IgDB220low) were identified in spleens, BM and cervical LNs (cLN) from 16–18–week-old WT, TCRβ/δ−/−, B6.Act1−/−, and TKO mice.
Figure 4. Relative levels of T1, T2, and T3 immature B-cell subsets in 16–18-week-old WT, TCRβ/δ−/−, B6.Act1−/−, and TKO mice.
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