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  • 1
    Wiesel, M., Walton, S., Richter, K.andOxenius, A., Virus-specific CD8 T cells: activation, differentiation and memory formation. APMIS 2009. 117: 356381.
  • 2
    Shin, H. and Wherry, E. J., CD8 T cell dysfunction during chronic viral infection. Curr. Opin. Immunol. 2007. 19: 408415.
  • 3
    Gruener, N. H., Lechner, F., Jung, M. C., Diepolder, H., Gerlach, T., Lauer, G., Walker, B.et al., Sustained dysfunction of antiviral CD8+ T lymphocytes after infection with hepatitis C virus. J. Virol. 2001. 75: 55505558.
  • 4
    Sewell, A. K., Price, D. A., Oxenius, A., Kelleher, A. D. and Phillips, R. E., Cytotoxic T lymphocyte responses to human immunodeficiency virus: control and escape. Stem Cells 2000. 18: 230244.
  • 5
    Oxenius, A., Sewell, A. K., Dawson, S. J., Gunthard, H. F., Fischer, M., Gillespie, G. M., Rowland-Jones, S. L.et al., Functional discrepancies in HIV-specific CD8+ T-lymphocyte populations are related to plasma virus load. J. Clin. Immunol. 2002. 22: 363374.
  • 6
    Pantaleo, G., Soudeyns, H., Demarest, J. F., Vaccarezza, M., Graziosi, C., Paolucci, S., Daucher, M.et al., Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infection. Proc. Natl. Acad. Sci. USA 1997. 94: 98489853.
  • 7
    Kostense, S., Vandenberghe, K., Joling, J., Van Baarle, D., Nanlohy, N., Manting, E.and Miedema, F., Persistent numbers of tetramer+ CD8(+) T cells, but loss of interferon-gamma+ HIV-specific T cells during progression to AIDS. Blood 2002. 99: 25052511.
  • 8
    Shankar, P., Russo, M., Harnisch, B., Patterson, M., Skolnik, P. and Lieberman, J., Impaired function of circulating HIV-specific CD8(+) T cells in chronic human immunodeficiency virus infection. Blood 2000. 96: 30943101.
  • 9
    Agnellini, P., Wolint, P., Rehr, M., Cahenzli, J., Karrer, U. and Oxenius, A., Impaired NFAT nuclear translocation results in split exhaustion of virus-specific CD8+ T cell functions during chronic viral infection. Proc. Natl. Acad. Sci. USA 2007. 104: 45654570.
  • 10
    Zajac, A. J., Blattman, J. N., Murali-Krishna, K., Sourdive, D. J., Suresh, M., Altman, J. D. and Ahmed, R., Viral immune evasion due to persistence of activated T cells without effector function. J. Exp. Med. 1998. 188: 22052213.
  • 11
    Wherry, E. J., Blattman, J. N., Murali-Krishna, K., van der Most, R. and Ahmed, R., Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J. Virol. 2003. 77: 49114927.
  • 12
    Fuller, M. J., Khanolkar, A., Tebo, A. E. and Zajac, A. J., Maintenance, loss, and resurgence of T cell responses during acute, protracted, and chronic viral infections. J. Immunol. 2004. 172: 42044214.
  • 13
    Moskophidis, D., Lechner, F., Pircher, H. and Zinkernagel, R. M., Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature 1993. 362: 758761.
  • 14
    Brooks, D. G., Trifilo, M. J., Edelmann, K. H., Teyton, L., McGavern, D. B. and Oldstone, M. B., Interleukin-10 determines viral clearance or persistence in vivo. Nat. Med. 2006. 12: 13011309.
  • 15
    Ejrnaes, M., Filippi, C. M., Martinic, M. M., Ling, E. M., Togher, L. M., Crotty, S. and von Herrath, M. G., Resolution of a chronic viral infection after interleukin-10 receptor blockade. J. Exp. Med. 2006. 203: 24612472.
  • 16
    Harker, J. A., Lewis, G. M., Mack, L. and Zuniga, E. I., Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection. Science 2011. 334: 825829.
  • 17
    Tinoco, R., Alcalde, V., Yang, Y., Sauer, K.and Zuniga, E. I., Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo. Immunity 2009. 31: 145157.
  • 18
    Wherry, E. J., T cell exhaustion. Nat. Immunol. 2011. 12: 492499.
  • 19
    Punkosdy, G. A., Blain, M., Glass, D. D., Lozano, M. M., O'Mara, L., Dudley, J. P., Ahmed, R.et al., Regulatory T-cell expansion during chronic viral infection is dependent on endogenous retroviral superantigens. Proc. Natl. Acad. Sci. USA 2011. 108: 36773682.
  • 20
    Matloubian, M., Concepcion, R. J.and Ahmed, R., CD4+ T cells are required to sustain CD8 +cytotoxic T-cell responses during chronic viral infection. J. Virol. 1994. 68: 80568063.
  • 21
    Elsaesser, H., Sauer, K.and Brooks, D. G., IL-21 is required to control chronic viral infection. Science 2009. 324: 15691572.
  • 22
    Frohlich, A., Kisielow, J., Schmitz, I., Freigang, S., Shamshiev, A. T., Weber, J., Marsland, B. J.et al., IL-21R on T cells is critical for sustained functionality and control of chronic viral infection. Science 2009. 324: 15761580.
  • 23
    Yi, J. S., Du, M. and Zajac, A. J., A vital role for interleukin-21 in the control of a chronic viral infection. Science 2009. 324: 15721576.
  • 24
    Rehr, M., Cahenzli, J., Haas, A., Price, D. A., Gostick, E., Huber, M., Karrer, U.et al., Emergence of polyfunctional CD8+ T cells after prolonged suppression of human immunodeficiency virus replication by antiretroviral therapy. J. Virol. 2008. 82: 33913404.
  • 25
    Mueller, S. N. and Ahmed, R., High antigen levels are the cause of T cell exhaustion during chronic viral infection. Proc. Natl. Acad. Sci. USA 2009. 106: 86238628.
  • 26
    Streeck, H., Brumme, Z. L., Anastario, M., Cohen, K. W., Jolin, J. S., Meier, A., Brumme, C. J.et al., Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells. PLoS. Med. 2008. 5: e100.
  • 27
    Day, C. L., Abrahams, D. A., Lerumo, L., Janse van Rensburg, E., Stone, L., O'Rie, T., Pienaar, B.et al., Functional capacity of Mycobacterium tuberculosis-specific T cell responses in humans is associated with mycobacterial load. J. Immunol. 2011.
  • 28
    Cannarile, M. A., Decanis, N., van Meerwijk, J. P. and Brocker, T., The role of dendritic cells in selection of classical and nonclassical CD8+ T cells in vivo. J. Immunol. 2004. 173: 47994805.
  • 29
    Probst, H. C. and van den Broek, M., Priming of CTLs by lymphocytic choriomeningitis virus depends on dendritic cells. J. Immunol. 2005. 174: 39203924.
  • 30
    Kagi, D., Ledermann, B., Burki, K., Seiler, P., Odermatt, B., Olsen, K. J., Podack, E. R.et al., Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 1994. 369: 3137.
  • 31
    Balkow, S., Kersten, A., Tran, T. T., Stehle, T., Grosse, P., Museteanu, C., Utermohlen, O. et al., Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection. J. Virol. 2001. 75: 87818791.
  • 32
    Lohler, J., Gossmann, J., Kratzberg, T. and Lehmann-Grube, F., Murine hepatitis caused by lymphocytic choriomeningitis virus. I. The hepatic lesions. Lab. Invest. 1994. 70: 263278.
  • 33
    Mueller, S. N., Matloubian, M., Clemens, D. M., Sharpe, A. H., Freeman, G. J., Gangappa, S., Larsen, C. P.et al., Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection. Proc. Natl. Acad. Sci. USA 2007. 104: 1543015435.
  • 34
    Ehl, S., Hombach, J., Aichele, P., Rulicke, T., Odermatt, B., Hengartner, H., Zinkernagel, R.et al., Viral and bacterial infections interfere with peripheral tolerance induction and activate CD8+ T cells to cause immunopathology. J. Exp. Med. 1998. 187: 763774.
  • 35
    Mach, N., Gillessen, S., Wilson, S. B., Sheehan, C., Mihm, M.andDranoff, G., Differences in dendritic cells stimulated in vivo by tumors engineered to secrete granulocyte-macrophage colony-stimulating factor or Flt3-ligand. Cancer Res. 2000. 60: 32393246.
  • 36
    Guidotti, L. G., Borrow, P., Brown, A., McClary, H., Koch, R.and Chisari, F. V., Noncytopathic clearance of lymphocytic choriomeningitis virus from the hepatocyte. J. Exp. Med. 1999. 189: 15551564.
  • 37
    Sydora, B. C., Jamieson, B. D., Ahmed, R.andKronenberg, M., Intestinal intraepithelial lymphocytes respond to systemic lymphocytic choriomeningitis virus infection. Cell Immunol. 1996. 167: 161169.
  • 38
    Zhou, S., Halle, A., Kurt-Jones, E. A., Cerny, A. M., Porpiglia, E., Rogers, M., Golenbock, D. T.et al., Lymphocytic choriomeningitis virus (LCMV) infection of CNS glial cells results in TLR2-MyD88/Mal-dependent inflammatory responses. J. Neuroimmunol. 2008. 194: 7082.
  • 39
    Durbeej, M., Henry, M. D., Ferletta, M., Campbell, K. P. and Ekblom, P., Distribution of dystroglycan in normal adult mouse tissues. J. Histochem. Cytochem. 1998. 46: 449457.
  • 40
    Borrow, P., Evans, C. F. and Oldstone, M. B., Virus-induced immunosuppression: immune system-mediated destruction of virus-infected dendritic cells results in generalized immune suppression. J. Virol. 1995. 69: 10591070.
  • 41
    Sevilla, N., Kunz, S., Holz, A., Lewicki, H., Homann, D., Yamada, H., Campbell, K. P.et al., Immunosuppression and resultant viral persistence by specific viral targeting of dendritic cells. J. Exp. Med. 2000. 192: 12491260.
  • 42
    Matloubian, M., Kolhekar, S. R., Somasundaram, T.andAhmed, R., Molecular determinants of macrophage tropism and viral persistence: importance of single amino acid changes in the polymerase and glycoprotein of lymphocytic choriomeningitis virus. J. Virol. 1993. 67: 73407349.
  • 43
    Bergthaler, A., Flatz, L., Hegazy, A. N., Johnson, S., Horvath, E., Lohning, M.and Pinschewer, D. D., Viral replicative capacity is the primary determinant of lymphocytic choriomeningitis virus persistence and immunosuppression. Proc. Natl. Acad. Sci. USA 2010. 107: 2164121646.
  • 44
    Bucks, C. M., Norton, J. A., Boesteanu, A. C., Mueller, Y. M.and Katsikis, P. D., Chronic antigen stimulation alone is sufficient to drive CD8+ T cell exhaustion. J. Immunol. 2009. 182: 66976708.
  • 45
    Mueller, S. N., Vanguri, V. K., Ha, S. J., West, E. E., Keir, M. E., Glickman, J. N., Sharpe, A. H.et al., PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice. J. Clin. Invest. 2010. 120: 25082515.
  • 46
    Han, S., Asoyan, A., Rabenstein, H., Nakano, N.andObst, R., Role of antigen persistence and dose for CD4+ T-cell exhaustion and recovery. Proc. Natl. Acad. Sci. USA 2010. 107: 2045320458.
  • 47
    Ehl, S., Klenerman, P., Zinkernagel, R. M.andBocharov, G., The impact of variation in the number of CD8(+) T-cell precursors on the outcome of virus infection. Cell Immunol. 1998. 189: 6773.
  • 48
    Moskophidis, D., Laine, E.and Zinkernagel, R. M., Peripheral clonal deletion of antiviral memory CD8+ T cells. Eur. J. Immunol. 1993. 23: 33063311.
  • 49
    Kim, J. V., Kang, S. S., Dustin, M. L.and McGavern, D. B., Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis. Nature 2009. 457: 191195.
  • 50
    Barber, D. L., Wherry, E. J., Masopust, D., Zhu, B., Allison, J. P., Sharpe, A. H., Freeman, G. J. et al., Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 2006. 439: 682687.
  • 51
    Jin, H. T., Anderson, A. C., Tan, W. G., West, E. E., Ha, S. J., Araki, K., Freeman, G. J. et al., Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proc. Natl. Acad. Sci. USA 2010. 107: 1473314738.
  • 52
    Blackburn, S. D., Shin, H., Haining, W. N., Zou, T., Workman, C. J., Polley, A., Betts, M. R. et al., Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat. Immunol. 2009. 10: 2937.
  • 53
    Battegay, M., Cooper, S., Althage, A., Banziger, J., Hengartner, H. and Zinkernagel, R. M., Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates. J. Virol. Methods 1991. 33: 191198.
  • 54
    Pascolo, S., Bervas, N., Ure, J. M., Smith, A. G., Lemonnier, F. A. and Perarnau, B., HLA-A2.1-restricted education and cytolytic activity of CD8(+) T lymphocytes from beta2 microglobulin (beta2m) HLA-A2.1 monochain transgenic H-2Db beta2m double knockout mice. J. Exp. Med. 1997. 185: 20432051.
  • 55
    Kurts, C., Cannarile, M., Klebba, I.and Brocker, T., Dendritic cells are sufficient to cross-present self-antigens to CD8 T cells in vivo. J. Immunol. 2001. 166: 14391442.
  • 56
    Pircher, H., Moskophidis, D., Rohrer, U., Burki, K., Hengartner, H.andZinkernagel, R. M., Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo. Nature 1990. 346: 629633.
  • 57
    Giraudo, E., Arese, M., Toniatti, C., Strasly, M., Primo, L., Mantovani, A., Ciliberto, G.et al.,IL-6 is an in vitro and in vivo autocrine growth factor for middle T antigen-transformed endothelial cells. J. Immunol. 1996. 157: 26182623.
  • 58
    Altman, J.D., Moss, P.A., Goulder, P.J., Barouch, D.H., McHeyzer-Williams, M.G., Bell, J.I., McMichael, A.J.et al.,Phenotypic analysis of antigen-specific T lymphocytes. Science 1996. 274: 9496.