• 1
    Wilson, M. E., Fineberg, H. V. and Colditz, G. A., Geographic latitude and the efficacy of bacillus Calmette-Guerin vaccine. Clin. Infect. Dis. 1995. 20: 982991.
  • 2
    Colditz, G. A., Berkey, C. S., Mosteller, F., Brewer, T. F., Wilson, M. E., Burdick, E. and Fineberg, H. V., The efficacy of bacillus Calmette-Guerin vaccination of newborns and infants in the prevention of tuberculosis: meta-analyses of the published literature. Pediatrics 1995. 96: 2935.
  • 3
    Trunz, B. B., Fine, P. and Dye, C., Effect of BCG vaccination on childhood tuberculous meningitis and miliary tuberculosis worldwide: a meta-analysis and assessment of cost-effectiveness. Lancet 2006. 367: 11731180.
  • 4
    Barreto, M. L., Cunha, S. S., Pereira, S. M., Genser, B., Hijjar, M. A., Yury Ichihara, M., de Brito, S. C. et al., Neonatal BCG protection against tuberculosis lasts for 20 years in Brazil. Int. J. Tuberc. Lung Dis. 2005. 9: 11711173.
  • 5
    Dantas, O. M., Ximenes, R. A., de Albuquerque Mde, F., da Silva, N. L., Montarroyos, U. R., de Souza, W. V., Pereira, T. C. et al., A case-control study of protection against tuberculosis by BCG revaccination in Recife, Brazil. Int. J. Tuberc. Lung Dis. 2006. 10: 536541.
  • 6
    McShane, H., Pathan, A. A., Sander, C. R., Keating, S. M., Gilbert, S. C., Huygen, K., Fletcher, H. A. et al., Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans. Nat. Med. 2004. 10: 12401244.
  • 7
    Beveridge, N. E., Price, D. A., Casazza, J. P., Pathan, A. A., Sander, C. R., Asher, T. E., Ambrozak, D. R. et al., Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte populations. Eur. J. Immunol. 2007. 37: 30893100.
  • 8
    Menozzi, F. D., Rouse, J. H., Alavi, M., Laude-Sharp, M., Muller, J., Bischoff, R., Brennan, M. J. et al., Identification of a heparin-binding hemagglutinin present in mycobacteria. J. Exp. Med. 1996. 184: 9931001.
  • 9
    Pethe, K., Alonso, S., Biet, F., Delogu, G., Brennan, M. J., Locht, C. and Menozzi, F. D., The heparin-binding haemagglutinin of M. tuberculosis is required for extrapulmonary dissemination. Nature 2001. 412: 190194.
  • 10
    Masungi, C., Temmerman, S., Van Vooren, J. P., Drowart, A., Pethe, K., Menozzi, F. D., Locht, C. et al., Differential T and B cell responses against Mycobacterium tuberculosis heparin-binding hemagglutinin adhesin in infected healthy individuals and patients with tuberculosis. J. Infect. Dis. 2002. 185: 513520.
  • 11
    Temmerman, S. T., Place, S., Debrie, A. S., Locht, C. and Mascart, F., Effector functions of heparin-binding hemagglutinin-specific CD8+ T lymphocytes in latent human tuberculosis. J. Infect. Dis. 2005. 192: 226232.
  • 12
    van Pinxteren, L. A., Cassidy, J. P., Smedegaard, B. H., Agger, E. M. and Andersen, P., Control of latent Mycobacterium tuberculosis infection is dependent on CD8 T cells. Eur. J. Immunol. 2000. 30: 36893698.
  • 13
    Temmerman, S., Pethe, K., Parra, M., Alonso, S., Rouanet, C., Pickett, T., Drowart, A. et al., Methylation-dependent Tcell immunity to Mycobacterium tuberculosis heparin-binding hemagglutinin. Nat. Med. 2004. 10: 935941.
  • 14
    Rahman, M. J. and Fernandez, C., Neonatal vaccination with Mycobacterium bovis BCG: potential effects as a priming agent shown in a heterologous prime-boost immunization protocol. Vaccine 2009. 27: 40384046.
  • 15
    Rouanet, C., Debrie, A. S., Lecher, S. and Locht, C., Subcutaneous boosting with heparin binding haemagglutinin increases BCG-induced protection against tuberculosis. Microbes. Infect. 2009. 11: 9951001.
  • 16
    Guerrero, G. G. and Locht, C., Recombinant HBHA boosting effect on BCG-induced immunity against Mycobacterium tuberculosis infection. Clin. Dev. Immunol. 2011. 2011: 730702.
  • 17
    Lalor, M. K., Smith, S. G., Floyd, S., Gorak-Stolinska, P., Weir, R. E., Blitz, R., Branson, K. et al., Complex cytokine profiles induced by BCG vaccination in UK infants. Vaccine 2010. 28: 16351641.
  • 18
    Burl, S., Adetifa, U. J., Cox, M., Touray, E., Ota, M. O., Marchant, A., Whittle, H. et al., Delaying bacillus Calmette-Guerin vaccination from birth to 4 1/2 months of age reduces postvaccination Th1 and IL-17 responses but leads to comparable mycobacterial responses at 9 months of age. J. Immunol. 2010. 185: 26202628.
  • 19
    Kagina, B. M., Abel, B., Bowmaker, M., Scriba, T. J., Gelderbloem, S., Smit, E., Erasmus, M. et al., Delaying BCG vaccination from birth to 10 weeks of age may result in an enhanced memory CD4 T cell response. Vaccine 2009. 27: 54885495.
  • 20
    Hougardy, J. M., Schepers, K., Place, S., Drowart, A., Lechevin, V., Verscheure, V., Debrie, A. S. et al., Heparin-binding-hemagglutinin-induced IFN-gamma release as a diagnostic tool for latent tuberculosis. PLoS One 2007. 2: e926.
  • 21
    Smith, S. G., Lalor, M. K., Gorak-Stolinska, P., Blitz, R., Beveridge, N. E., Worth, A., McShane, H. et al., Mycobacterium tuberculosis PPD-induced immune biomarkers measurable in vitro following BCG vaccination of UK adolescents by multiplex bead array and intracellular cytokine staining. BMC Immunol. 2010. 11: 35.
  • 22
    Soares, A. P., Scriba, T. J., Joseph, S., Harbacheuski, R., Murray, R. A., Gelderbloem, S. J., Hawkridge, A. et al., Bacillus calmette-guerin vaccination of human newborns induces T cells with complex cytokine and phenotypic profiles. J. Immunol. 2008. 180: 35693577.
  • 23
    Tomlinson, G. S., Cashmore, T. J., Elkington, P. T., Yates, J., Lehloenya, R. J., Tsang, J., Brown, M. et al., Transcriptional profiling of innate and adaptive human immune responses to mycobacteria in the tuberculin skin test. Eur. J. Immunol. 2011. 41: 32533260.
  • 24
    Lalor, M. K., Ben-Smith, A., Gorak-Stolinska, P., Weir, R. E., Floyd, S., Blitz, R., Mvula, H. et al., Population differences in immune responses to bacille Calmette-Guerin vaccination in infancy. J. Infect. Dis. 2009. 199: 795800.
  • 25
    Ottenhoff, T. H., De Boer, T., van Dissel, J. T. and Verreck, F. A., Human deficiencies in type-1 cytokine receptors reveal the essential role of type-1 cytokines in immunity to intracellular bacteria. Adv. Exp. Med. Biol. 2003. 531: 279294.
  • 26
    Pearl, J. E., Saunders, B., Ehlers, S., Orme, I. M. and Cooper, A. M., Inflammation and lymphocyte activation during mycobacterial infection in the interferon-gamma-deficient mouse. Cell Immunol. 2001. 211: 4350.
  • 27
    Flynn, J. L., Chan, J., Triebold, K. J., Dalton, D. K., Stewart, T. A. and Bloom, B. R., An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J. Exp. Med. 1993. 178: 22492254.
  • 28
    Cooper, A. M., Dalton, D. K., Stewart, T. A., Griffin, J. P., Russell, D. G. and Orme, I. M., Disseminated tuberculosis in interferon gamma gene-disrupted mice. J. Exp. Med. 1993. 178: 22432247.
  • 29
    Black, G. F., Weir, R. E., Floyd, S., Bliss, L., Warndorff, D. K., Crampin, A. C., Ngwira, B. et al., BCG-induced increase in interferon-gamma response to mycobacterial antigens and efficacy of BCG vaccination in Malawi and the UK: two randomised controlled studies. Lancet 2002. 359: 13931401.
  • 30
    Wedlock, D. N., Denis, M., Vordermeier, H. M., Hewinson, R. G. and Buddle, B. M., Vaccination of cattle with Danish and Pasteur strains of Mycobacterium bovis BCG induce different levels of IFNgamma post-vaccination, but induce similar levels of protection against bovine tuberculosis. Vet. Immunol. Immunopathol. 2007. 118: 5058.
  • 31
    Elias, D., Akuffo, H. and Britton, S., PPD induced in vitro interferon gamma production is not a reliable correlate of protection against Mycobacterium tuberculosis. Trans. R. Soc. Trop. Med. Hyg. 2005. 99: 363368.
  • 32
    Majlessi, L., Simsova, M., Jarvis, Z., Brodin, P., Rojas, M. J., Bauche, C., Nouze, C. et al., An increase in antimycobacterial Th1-cell responses by prime-boost protocols of immunization does not enhance protection against tuberculosis. Infect. Immun. 2006. 74: 21282137.
  • 33
    Mittrucker, H. W., Steinhoff, U., Kohler, A., Krause, M., Lazar, D., Mex, P., Miekley, D. et al., Poor correlation between BCG vaccination-induced T cell responses and protection against tuberculosis. Proc. Natl. Acad. Sci. USA 2007. 104: 1243412439.
  • 34
    Anderson, L., Moore, J., Kruijshaar, M., Pedrazzoli, D., Bradshaw, L., Crofts, J., Stagg, H. et al., Tuberculosis in the UK: annual report on tuberculosis surveillance in the UK, 2010. Health Protection Agency Centre for Infections, London, October 2010.
  • 35
    Anderson, C., Maguire, H., Anderson, S., Carless, J. and Kanfoudi, L., Tuberculosis in London 2009: annual report on tuberculosis surveillance in London. Health Protection Agency London Regional Epidemiology Unit, London, January 2011.