• 1
    Cella, M., Jarrossay, D., Facchetti, F., Alebardi, O., Nakajima, H., Lanzavecchia, A. and Colonna, M., Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat. Med. 1999. 5: 919923.
  • 2
    Stetson, D. B. and Medzhitov, R., Type I interferons in host defence. Immunity 2006. 25: 373381.
  • 3
    Petska, S., Krause, C. D. and Walter, M. R., Interferons, interferon-like cytokines, and their receptors. Immunol. Rev. 2004. 202: 932.
  • 4
    Herbeuval, J. P. and Shearer, G. M., HIV-1 immunopathogenesis: how good interferon turns bad. Clin. Immunol. 2007. 123: 121128.
  • 5
    Chaperot, L., Blum, A., Manches, O., Lui, G., Angel, J., Molens, J.-P. and Plumas, J., Virus or TLR agonists induce TRAIL-mediated cytotoxic activity of plasmacytoid dendritic cells. J. Immunol. 2006. 176: 248255.
  • 6
    Matsui, T., Connolly, J. E., Michnevitz, M., Chaussabel, D., Yu, C.-I., Glaser, C., Tindle, S. et al., CD2 distinguished two subsets of human plasmacytoid dendritic cells with distinct phenotype and function. J. Immunol. 2009. 182: 68156823.
  • 7
    Blum, A., Chaperot, L., Molens, J.-P., Foissoud, V., Plantaz, D. and Plumas, J., Mechanisms of TRAIL-induced apoptosis in leukemic plasmacytoid dendritic cells. Exp. Hemat. 2006. 34: 16551662.
  • 8
    Stary, G., Bangert, C., Tauber, M., Strohal, R., Kopp, T. and Stingl, G., Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells. J. Exp. Med. 2007. 204: 14411451.
  • 9
    Stary, G., Klein, I., Kohlhofer, S., Koszik, F., Scherzer, T., Mullauer, L., Quendler, H. et al., Plasmacytoid dendritic cells express TRAIL and induce CD4+ T-cell apoptosis in HIV-1 viremic patients. Blood 2009. 114: 38543863.
  • 10
    Hardy, A. W., Graham, D.R., Shearer, G.M. and Herbeuval, J.-P., HIV turns plasmacytoid dendritic cells (pDC) into TRAIL-expressing killer pDC and down-regulated HIV coreceptors by toll-like receptor 7-induced IFN-alpha. Proc. Natl. Acad. Sci USA 2007. 104: 1745317458.
  • 11
    Sato, K., Hida, H., Takayanagi, H., Yokochi, N., Kayagaki, K., Takeda, K., Yagita, H. et al., Antiviral response by natural killer cells through TRAIL gene induction by IFN-a/b. Eur. J. Immunol. 2001. 31: 31383146.
  • 12
    Kirshner, J. R., Karpova, A. Y., Kops, M. and Howley, P. M., Identification of TRAIL as an interferon regulatory factor 3 transcriptional target. J. Virol. 2005. 79: 93209324.
  • 13
    Di Domizio, J., Blum, A., Gallagher-Gambarelli, M., Molens, J.-P., Chaperot, L. and Plumas, J., TLR7 stimulation in human plasmacytoid dendritic cells leads to the induction of early IFN-inducible genes in the absence of type I IFN. Blood 2009. 114: 17941802.
  • 14
    Svaren, J., Sevetson, B. R., Apel, E. D., Zimonijc, D. B., Popescu, N. C. and Milbrandt, J., NAB2, a corepressor of NGFI-A (EGR-1) and Krox20, is induced by proliferative and differentiative stimuli. Mol. Cell. Biol. 1996. 16: 35453553.
  • 15
    Droin, N. M., Pinkoski, M. J., Dejardin, E. and Green, D. R., Egr family members regulate nonlymphoid expression of Fas ligand, TRAIL, and tumor necrosis factor during immune responses. Mol. Cell. Biol. 2003. 23: 76387647.
  • 16
    Baron, V., Adamson, E. D., Calogero, A., Ragona, G. and Mercola, D., The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFβ1, PTEN, p53 and fibronection. Cancer Gene Ther. 2008. 13: 115124.
  • 17
    Zhu, B., Symonds, A. L., Martin, J. E., Kioussis, D., Wraith, D. C., Li, S. and Wang, P., Early growth response gene 2 (EGR-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease. J. Exp. Med. 2008. 205: 22952307.
  • 18
    Safford, M., Collins, S., Lutz, M. A., Allen, A., Huang, C. T., Kowalski, J., Blackford, A. et al., EGR-2 and EGR-3 are negative regulators of T-cell activation. Nat. Immunol. 2005. 6: 472480.
  • 19
    Collins, S., Lutz, M. A., Zaker, P. E., Anders, R. A., Kersh, G. J. and Powell, J. D., Opposing regulation of T-cell function by EGR-1/NAB2 and EGR-2/EGR-3. Eur. J. Immunol. 2008. 38: 528536.
  • 20
    Collins, S., Wolfraim, L. A., Drake, C. G., Horton, M. R. and Powell, J. D., Cutting edge: TCR induced NAB2 enhances T-cell function by coativating IL-2 trascription. J. Immunol. 2006. 177: 83018305.
  • 21
    Wolkers, M. C., Gerlach, C., Arens, R., Janssen, E. M., Fitzgerald, P., Schumacher, T. N., Medema, J. P. et al., Nab2 regulates secondary CD8+ T-cell responses through control of TRAIL expression. Blood 2012. 119: 798804.
  • 22
    Hornung, V., Rothenfusser, S., Britsch, S., Krug, A., Jahnsdorfer, B., Giese, T., Endres, S. et al., Quantitative expression of toll-like receptor 1–10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J. Immunol. 2002. 168: 45314537.
  • 23
    Maeda, T., Murata, K., Fukushima, T., Sugahara, K., Tsuruda, K., Anami, M., Onimaru, Y. et al., A novel plasmacytoid dendritic cell line, CAL-1, estabilished from a patient with blastic natural killer cell lymphoma. Int. J. Hemat. 2004. 81: 148154.
  • 24
    Karrich, J. J., Balzarolo, M., Schmidlin, H., Libouban, M., Nagasawa, M., Gentek, R., Kamihira, S. et al., The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1. Blood 2012. 119: 51915200.
  • 25
    Kalb, M. L., Glaser, A., Stary, G., Koszik, F. and Stingl, G., TRAIL(+) human plasmacytoid dendritic cells kill tumor cells in vitro: mechanisms of imiquimod- and IFN-alpha-mediated antitumor reactivity. J Immunol. 188: 15831591.
  • 26
    Svaren, J., Sevetson, B. R., Golda, T., Stanton, J. J., Swirnoff, A. H. and Milbrandt, J., Novel mutants on NAB corepressors enhance activation by EGRtransactivators. EMBO J. 1998. 17: 60106019.
  • 27
    Kumbrink, J., Kirsch, K. H. and Johnson, J. P., EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin. J. Cell. Biochem. 2010. 111: 207217.
  • 28
    Waibler, Z., Anzaghe, M., Frenz, T., Schwantes, A., Pohlmann, C., Ludwig, H., Palomo-Otero, M. et al., Vaccinia virus-mediated inhibition of type I interferon responses is a multifactorial process involving the soluble type I interferon receptor B18R and intracellular components. J. Virol. 2009. 83: 15631571.
  • 29
    Symons, J. A., Alcami, A. and Smith, G. L., Vaccinia virus encodes a soluble type I interferon receptor of novel structure and broad species specificity. Cell 1996. 81: 551560.
  • 30
    Alcami, A., Symons, J. A. and Smith, G. L., The vaccinia virus soluble alpha/beta interferon (IFN) receptor binds to the cell surface and protects cell from antiviral effects of IFN. J. Virol. 2000. 74: 1123011239.
  • 31
    Riboldi, E., Daniele, R., Cassatella, M. A., Sozzani, S. and Bosisio, D., Engagement of BDCA-2 blocks TRAIL-mediated cytotoxic activity of plasmacytoid dendritic cells. Immunobiology 2009. 214: 868876.
  • 32
    Osawa, Y., Iho, S., Takauji, R., Takatsuka, H., Yamamoto, S., Takahashi, T., Horiguchi, S. et al., Collaborative action of NF-kB and p38 MAPK is involved in CpG DNA-induced IFN-α and chemokine production in human plasmacytoid dendritic cells. J. Immunol. 2006. 177: 48414852.
  • 33
    Takauji, R., Iho, S., Takatsuka, H., Yamamoto, S., Takahashi, T., Kitagawa, H., Iwasaki, H. et al., CpG-DNA-induced IFN-a production involves p38 MAPK-dependent STAT1 phosphorylation in human plasmacytoid dendritic cells precursors. J. Leukoc. Biol. 2002. 72: 10111019.
  • 34
    Guiducci, C., Ghirelli, C., Marloie-Provost, M.-A., Matray, T., Coffman, R.L., Liu, Y.-L., Barrat, F.J. et al., PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation. J. Exp. Med. 2008. 205: 315322.
  • 35
    Sevetson, B. R., Svaren, J. and Milbrandt, J., A novel activation function for NAB proteins in EGR-dependent transcription of the luteinizing hormone beta gene. J. Biol. Chem. 2000. 275: 97499757.
  • 36
    Srinivasan, R., Mager, G. M., Ward, R. M., Mayer, J. and Svaren, J., NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex. J. Biol. Chem. 2006. 281: 1512915137.
  • 37
    Kerkmann, M., Rothenfusser, S., Hornung, V., Towarowski, V., Wagner, M., Sarris, A., Giese, T. et al., Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells. J. Immunol. 2003. 170: 44654474.
  • 38
    Gautier, G., Humbert, M., Deauvieau, F., Scuiller, M., Hiscott, J., Bates, E. E. M., Trinchieri, G. et al., A type I interferon autocrine-paracrine loop is involved in toll-like receptor-induced interleukin-12p70 secretion by dedritic cells. J. Exp. Med. 2005. 201: 14351446.
  • 39
    van Lent, A. U., Dontije, W., Nagasawa, M., Siamari, R., Bakker, A. Q., Pouw, S. M., Maijoor, K. A. et al., IL-7 enhances thymic human T-cell development in “Human Immune System” Rag2-/-IL-2R {gamma} c-/- mice without affecting peripheral T-cell homeostasis. J. Immunol. 2009. 183: 76457655.