Type 2 innate lymphoid cells–new members of the “type 2 franchise” that mediate allergic airway inflammation
Version of Record online: 26 APR 2012
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
European Journal of Immunology
Volume 42, Issue 5, pages 1093–1096, May 2012
How to Cite
Mjösberg, J. and Spits, H. (2012), Type 2 innate lymphoid cells–new members of the “type 2 franchise” that mediate allergic airway inflammation. Eur. J. Immunol., 42: 1093–1096. doi: 10.1002/eji.201242549
- Issue online: 26 APR 2012
- Version of Record online: 26 APR 2012
- Manuscript Revised: 13 APR 2012
- Manuscript Accepted: 28 MAR 2012
- Manuscript Received: 20 MAR 2012
- See accompanying article by Klein Wolterink et al.
- Lung inflammation;
- Innate immunity;
Type 2 innate lymphoid cells (ILC2s) are members of an ILCfamily, which contains NKcells and Rorγt+ ILCs, the latter including lymphoid tissue inducer (LTi) cells and ILCs producing IL-17 and IL-22. ILC2s are dedicated to the production of IL-5 and IL-13 and, as such, ILC2s provide an early and important source of type 2 cytokines critical for helminth expulsion in the gut. Several studies have also demonstrated a role for ILC2s in airway inflammation. In this issue of the European Journal of Immunology, Klein Wolterink et al. [Eur. J. Immunol. 2012. 42: 1106-1116] show that ILC2s are instrumental in several models of experimental asthma where they significantly contribute to production of IL-5 and IL-13, key cytokines in airway inflammation. This study sheds light over the relative contribution of ILC2s versus T helper type 2 cells (Th2) in type 2 mediated allergen-specific inflammation in the airways as discussed in this commentary.