See accompanying article by Bellora et al.
Membrane interleukin-18 revisits membrane IL-1α in T-helper type 1 responses
Article first published online: 8 JUN 2012
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
European Journal of Immunology
Volume 42, Issue 6, pages 1385–1387, June 2012
How to Cite
Dinarello, C. A. (2012), Membrane interleukin-18 revisits membrane IL-1α in T-helper type 1 responses. Eur. J. Immunol., 42: 1385–1387. doi: 10.1002/eji.201242635
- Issue published online: 8 JUN 2012
- Article first published online: 8 JUN 2012
- Manuscript Accepted: 30 APR 2012
- Manuscript Received: 23 APR 2012
- Manuscript Revised: 23 APR 2012
- T cells
Although all structural studies on cytokine–cytokine receptor interactions are based on a crystallized cytokine binding to its specific receptor, there is no dearth of evidence that membrane-embedded cytokines are biologically active by virtue of cell–cell contact. Clearly the orientation of the membrane cytokine is such that it allows binding to the receptor, as takes place with the soluble form of the cytokine. In this issue, Bellora et al. [Eur. J. Immunol. 2012. 42: 1618–1626] report that interleukin-18 (IL-18) exists as an integral membrane protein on M-CSF-differentiated human macrophages and that upon LPS stimulation, IL-18 induces IFN-γ from NK cells in a caspase-1-dependent fashion. The immunological and inflammatory implications for this finding are considerable because of the role of IL-18 as the primary IFN-γ inducing cytokine in promoting Th1 responses.